#9902 MSDS Material Safety Data Sheet (MSDS) for Serine/
Threonine Phosphatase Inhibitor (Calyculin A) 166B Cummings Center I Beverly, MA 01915
Orders I 877-616-CELL (2355) Support I 877-678-TECH (8324) Web I www.cellsignal.com
orders@cellsignal.com info@cellsignal.com
Signs and Symptoms of Exposure
I. Identification Acute effects of overexposure鈥擭ot known. Harmful if swallowed, inhaled,
or absorbed through skin. Causes severe irritation. Inhalation may be fatal
Product name: Serine/Threonine Phosphatase Inhibitor (Calyculin A)
as a result of spasm, inflammation and edema of the larynx and bronchi,
Chemical name: Calyculin A chemical pneumonitis and pulmonary edema. Symptoms of exposure may
include burning sensation, coughing, wheezing, laryngitis, shortness of
CAS number: 101932-71-2
breath, headache, nausea and vomiting.
Empirical formula: C50 H81 N4 O15 P
Acute Overexposure
Molecular weight: 1009.18 Acute effects of swallowing鈥擭ot known
Chemical family: Polyene phosphate Acute effects of skin absorption鈥擭ot known
Acute effects of inhalation鈥擭ot known; presumed to be very toxic
II. Physical Data Acute effects of skin contact鈥擭ot known
Boiling point: N/A (solid compound) Acute effects of eye contact鈥擭ot known; presumed to be very toxic
Specific gravity: N/A (solid compound) Chronic effects of overexposure: Effects in humans not known; may be
a carcinogen or tumor promoter
Vapor density: N/A (solid compound)
Emergency and First Aid Procedures
Percent volatile by volume: N/A (solid compound)
Inhalation鈥擱emove by gastric lavage or emesis. Maintain blood pressure
Freezing point: Solid at working temperatures and airway. Give oxygen if respiration is depressed. Do not perform gastric
lavage or emesis if victim is unconscious. Get medical attention immediate-
Vapor pressure at 20掳C: N/A (solid compound)
ly (Dreisbach, Handbook of Poisoning, 11th edition). Administration of gas-
Solubility in water: Not soluble tric lavage or oxygen should be performed by qualified medical personnel
(very toxic).
Appearance: Clear or whitish film adhering to inside of tube
Ingestion鈥擨f swallowed, call a physician. Wash contaminated clothing
before reuse. Acute exposure may cause irritation of the gastrointestinal
III. Ingredients tract, headache, dizziness, nausea, vomiting, weight loss, and abdominal
spasms. Effects on fertility have been reported from a single exposure dur-
Material: Supplied as pure compound
ing pregnancy in rats. Effects on the embryo or fetus have been reported
from a single exposure during pregnancy in rats. Chronic exposure and/or
prolonged exposure from ingestion may cause liver and kidney damage.
IV. Fire and Explosion Hazard Data Effects on fertility have been reported from repeated exposure during gesta-
tion in rabbits. Effects on the embryo or fetus have been reported from
Flash point: N/A (solid compound)
repeated exposure during gestation in rabbits. Fetal developmental abnor-
Auto-ignition temperature: N/A malities have been reported from prolonged ingestion during gestation in
rats and rabbits. Consult physician in all cases of exposure.
Flammable limits in air (% by volume): Material is solid.
Skin鈥擮btain medical attention, as needed. Acute exposure may cause irri-
Extinguishing media: Compound not to be used above milligram
tation with redness and pain and may be absorbed through intact skin.
amounts; fire extinguishing media should match other materials in fire.
Chronic exposure may cause effects that are dependent upon concentration
Special fire fighting procedures: If involved in fire, don NIOSH/ and duration of exposure. Conjunctivitis or effects similar to those for acute
MSHA-approved self-contained breathing apparatus that is flame/ exposure may occur (very toxic).
chemical resistant.
Eyes鈥擶ash thoroughly with copious amounts of water or normal saline for
Unusual fire and explosion hazards: Emits toxic fumes under fire at least 15 minutes while removing contaminated clothing and shoes.
conditions. Assure adequate flushing of the eyes by separating the eyelids with fingers.
Obtain medical attention.
V. Health Hazard Data
漏 2000 Cell Signaling Technology, Inc.
VI. Reactivity Data
Irritant
Stability/conditions to avoid: Not reactive as far as known
Threshold Limit Value (TLV) and source: Data not available; com-
pound very toxic. Incompatibility/Materials to avoid: None known
Chemical listed as carcinogen or potential carcinogen: Yes Combustion/Decomposition products: Undetermined
Hazardous polymerization: Not susceptible to polymerization
page 1 of 2
#9902 MSDS Material Safety Data Sheet (MSDS) for Serine/
Threonine Phosphatase Inhibitor (Calyculin A) 166B Cummings Center I Beverly, MA 01915
Orders I 877-616-CELL (2355) Support I 877-678-TECH (8324) Web I www.cellsignal.com
orders@cellsignal.com info@cellsignal.com
VII. Spill or Leak Procedures IX. Special Precautions
Steps to be taken if material is spilled or released: No guidelines Precautions to be taken in handling and storage: This compound is
exist for making recommendations in this section. sold only for research use by Ph.D.-level scientists familiar with the toxicol-
ogy of organic chemicals and tumor promoters and who are well trained in
Waste disposal method: Dispose of as cancer suspect agent. Observe good laboratory habits, such as keeping hands clean at all times and not
all federal, state, and local regulations when storing or disposing of this rubbing eyes with hands while working in the laboratory.
substance. For assistance, contact the district director of the Environmental
Protection Agency. This compound is sold only in milligram quantities for use in extremely
dilute solutions in biological research. No other use is intended and any
Precautions other use involves substantial hazards. This compound should never be
Safety shower and eye bath. handled in powder or aerosol form or in any other form susceptible to
uncontrolled release in the laboratory, even in very small quantities.
Do not get in eyes, on skin, or on clothing.
This compound is to be stored only in milligram quantities as dilute, tightly
Wash thoroughly after handling.
stoppered solutions kept under nitrogen or argon, or kept as supplied in a
Observe all federal, state and local laws. sealed amber plastic tube.
The above information is believed to be correct but does not purport to be
all inclusive and shall be used only as a guide for experienced personnel.
VIII. Special Protection Information
Cell Signaling Technology, Inc., shall not be held liable for any damage
Respiratory protection: Do not work with this compound in powder or resulting from the handling of or from contact with the above product. The
aerosol form. burden of safe use of this material rests entirely with the user.
Ventilation: Do not work with this compound in powder or aerosol form.
Protective equipment: Wear suitable protective clothing, chemical resist- Revised: December 2000
ant gloves and lab safety glasses.
漏 2000 Cell Signaling Technology, Inc.
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