MSDS: Tolfenamic Acid 2/27/02 4:02 PM
MATERIAL SAFETY DATA SHEET
This form complies with OSHA's Hazard Communication Standard, 29 CFR 1910.1200.
IDENTITY (As Used on Label and List): Tolfenamic Acid
SECTION I - Product Identification
Tolfenamic Acid
Manufacturer Name and Address: Telephone #s: Dates:
Cayman Chemical Company Cayman Chemical Comp (800)364-9897 Date Entered: 06/27/1996
1180 E. Ellsworth Rd. Last Revision: 12/19/2000
Ann Arbor, MI. 48108 Cayman Chemical Comp (734)971-3335 MSDS Printed: 12/19/2000
Synonyms:
2-[(3-chloro-2-methylphenyl)amino]-benzoic acid;
Clotam;
N-(3-chloro-O-tolyl)-anthranilic acid;
GEA 6414
Chemical Family: Inhibitors
Hazard Label: Health: 2
Molecular Formula: C14H12ClNO2 Flammability: 0 , Molecular Weight: 261.72 Reactivity: 0
SECTION II - Hazardous Ingredients/Identity Information
Tolfenamic Acid
Hazardous Components (Specific Chemical Identity/Common OSHA ACGIH Other
CAS # Percentage
Name) PEL TLV Limits
Tolfenamic Acid 13710-19-5 100.0
SECTION III - Physical/Chemical Characteristics
Tolfenamic Acid
Boiling Point: NE or NA Specific Gravity (Water = 1): Melting Point: 202.0 C Vapor Pressure (mm Hg): . . . NE or NA to: 213.0 C Vapor
Density (Air=1):. . . . NE or NA Evaporation Rate: . . . . . . NE or NA Physical States: [ ] Gas (Butyl Acetate=1) [ ] Liquid Solubility In
Water:. . . . . <50 ug/ml* at 25.0 C [ X ] Solid *PBS pH 7.2, sol. in EtOH, DMSO, & DMF Percent Volatile: . . . . . . NE or NA Appearance
and Odor:
A crystalline solid
SECTION IV - Fire and Explosion Hazard Data
Tolfenamic Acid
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Flash Pt: NE or NA Method Used:
Explosive Limits: LEL: UEL:
Autoignition Pt: NE or NA Extinguishing Media:
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.
Special Fire Fighting Procedures:
As in any fire, wear self-contained breathing apparatus pressure-demand (MSHA/NIOSH approved or equivalent), and full
protective gear to prevent contact with skin and eyes.
Unusual Fire and Explosion Hazards:
Emits toxic fumes under fire conditions.
SECTION V - Reactivity Data
Tolfenamic Acid
Stability: Unstable [ ] Stable [ X ]
Conditions To Avoid - Instability:
Incompatibility - Materials To Avoid:
Hazardous Decomposition Or Byproducts:
carbon dioxide
carbon monoxide
nitrogen oxides
hydrogen chloride
Hazardous Polymerization: May occur [ ] Will not occur [ X ]
Conditions To Avoid - Hazardous Polymerization:
SECTION VI - Health Hazard Data
Tolfenamic Acid
Route(s) of Entry: Inhalation? Yes , Skin? Yes , Eyes? Yes , Ingestion? Yes , Other:
Health Hazards (Acute and Chronic):
Contact may cause skin or eye irritation.
The toxicological properties of this compound have not been fully evaluated.
Carcinogenicity: NTP? No , IARC Monographs? No , OSHA Regulated? No
Carcinogenicity/Other Information:
Toxicity Data:
Orl-Rat LD50: 225 mg/kg TOIZAG 28,99,1981
Ipr-Rat LD50: 238 mg/kg TOIZAG 29,851,1983
Scu-Rat LD50: 246 mg/kg IYKEDH 14,838,1983
Orl-Mus LD50: 280 mg/kg IYKEDH 14,838,1983
Ipr-Mus LD50: 185 mg/kg IYKEDH 14,838,1983
Scu-Mus LD50: 267 mg/kg IYKEDH 14,838,1983
Orl-Rbt LD50: 562 mg/kg TOIZAG 29,851,1983
Target Organ Data:
Behavioral (Altered sleep time)
Behavioral (Somnolence)
Behavioral (Ataxia)
Lungs, thorax, or respiration (Respiratory stimulation)
Gastrointestinal (Changes in the structure or function of salivary glands)
Specific developmental abnormalities (Musculoskeletal system)
Specific developmental abnormalities (Cardiovascular system)
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Effects on newborn (Weaning or lactation index)
Effects on newborn (Growth statistics)
Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete
information.
Recommended Exposure Limits: LD 50/LC 50:
Signs and Symptoms Of Exposure:
Irritating to the skin, eyes, nose, throat, and respiratory tract.
Medical Conditions Generally Aggravated By Exposure:
Emergency and First Aid Procedures:
If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get immediate medical
attention.
If swallowed, wash out mouth with water provided person is conscious. Never give anything by mouth to an unconscious person.
Get medical attention.
In case of contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial flushings, remove any contact lenses
and continue flushing for at least 15 minutes. Have eyes examined and tested by medical personnel.
In case of skin contact, immediately wash skin with soap and plenty of water. Remove contaminated clothing. Get medical attention if
symptoms occur. Wash clothing before reuse.
SECTION VII - Precautions for Safe Handling and Use
Tolfenamic Acid
Steps To Be Taken In Case Material Is Released Or Spilled:
Wear a self-contained breathing apparatus and appropriate personal protection. (See Exposure Controls/Personal Protection Section)
Sweep up material and place in disposal container.
Avoid raising dust.
After removal, ventilate contaminated area and flush thoroughly with water.
Waste Disposal Method:
Dispose in accordance with local, state and federal regulations.
Hazard Label Information:
Avoid contact with skin and eyes. Do not reuse this container.
Use with adequate ventilation. Wash thoroughly after handling.
Precautions To Be Taken in Handling and Storing:
Avoid contact with eyes, skin, and clothing.
Do not reuse this container.
Store at correct temperature.
Use with adequate ventilation.
Wash thoroughly after handling.
Other Precautions:
SECTION VIII- Control Measures
Tolfenamic Acid
Protective Equipment Summary - Hazard Label Information
Eye wash station in work area Lab coat Latex disposable gloves
Safety glasses Safety shower in work area Vent Hood
Respiratory Equipment (Specify Type):
Ventilation:
Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne levels below recommended
exposure limits.
Eye Protection:
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Safety glasses
Protective Gloves:
Latex disposable gloves
Other Protective Clothing:
Lab coat
Work/Hygienic/Maintenance Practices:
Do not take internally.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Wash thoroughly after handling.
SECTION IX - Additional Comments
Tolfenamic Acid
For research use only, not for human or veterinary clinical use. DISCLAIMER:
This information is believed to be accurate and represents the best information currently available to us. However, we make no
warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability
resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular
purposes.
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