SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 16/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEXAMETHYLDISILAZANE
Product Number H4875
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
1,1,1,3,3,3-HEXAMETHYLDISILAZANE 999-97-3 213-668-5 None
Formula C6H19NSi2
Molecular Weight 161.4 AMU
Synonyms Bis(trimethylsilyl)amine * Hexamethyldisilazane
* 1,1,1,3,3,3-Hexamethyldisilazane * HMDS * OAP
* Silanamine,
1,1,1-trimethyl-N-(trimethylsilyl)- (9CI) * SZ
6079 *
1,1,1-Trimethyl-N-(trimethylsilyl)silanamine *
Tri-Sil * TSL 8802
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation, in contact with skin and
if swallowed. Causes burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Handle and store under nitrogen.
Store at 2-8藲C
SPECIAL REQUIREMENTS: Readily hydrolyzed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH >7
BP/BP Range 124 - 127 藲C
MP/MP Range N/A
Flash Point 14 藲C Method: closed cup
Flammability N/A
Autoignition Temp 380 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 0.8 %
Upper: 16.3 %
Vapor Pressure 15 mmHg 20 藲C
SG/Density 0.774 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 4.6 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Other Solvents: MOSTCOMMON ORGANIC SOLVENTS
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Readily hydrolyzed.
Conditions to Avoid: Ammonia is formed upon contact with water or
humid air.
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Silicon oxide, Nitrogen oxides, Formaldehyde.
Hazardous Decomposition Products Formed Upon Contact with Water:
Ammonia
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: JM9230000
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ACUTE TOXICITY
LD50
Oral
Rat
850 mg/kg
Remarks: Behavioral:General anesthetic. Cardiac:Pulse rate.
Lungs, Thorax, or Respiration:Respiratory depression.
LC50
Inhalation
Rat
8,700 mg/m3
4H
Remarks: Behavioral:General anesthetic. Cardiac:Pulse rate.
Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Intraperitoneal
Rat
800 MG/KG
Remarks: Behavioral:Tremor. Behavioral:Muscle weakness. Skin and
Appendages: Other: Hair.
LD50
Oral
Mouse
850 mg/kg
Remarks: Behavioral:General anesthetic. Cardiac:Pulse rate.
Lungs, Thorax, or Respiration:Respiratory depression.
LC50
Inhalation
Mouse
12,000 mg/m3
2H
Remarks: Behavioral:General anesthetic. Cardiac:Pulse rate.
Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Intravenous
Mouse
>100 MG/KG
LD50
Oral
Rabbit
1100 mg/kg
Remarks: Behavioral:General anesthetic. Cardiac:Pulse rate.
Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Skin
Rabbit
710 UL/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Other changes.
Gastrointestinal:Other changes.
LD50
Skin
Guinea pig
SIGMA - H4875 www.sigma-aldrich.com Page 4
1 ML/KG
Remarks: Behavioral:Tremor. Behavioral:Muscle weakness. Skin and
Appendages: Other: Hair.
IRRITATION DATA
Skin
Rabbit
0.5 ml
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. Harmful if
inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CHRONIC EXPOSURE - CARCINOGEN
Mouse
Route of Application: Intraperitoneal
Exposure Time: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Brachydanio rerio
Time: 96 h
Value: 88 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 80 mg/l
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: 19 mg/l
13 - Disposal Considerations
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SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3286
Class: 3
PG: II
Proper Shipping Name: Flammable liquid, toxic,
corrosive, n.o.s.
IMDG
UN#: 3286
Class: 3
PG: II
Subrisk: 6.1/8
Proper Shipping Name: FLAMMABLE LIQUID, TOXIC,
CORROSIVE, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3286
Class: 3
PG: II
Subrisk: 6.18
Proper Shipping Name: Flammable liquid, toxic,
corrosive, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: F C
Highly Flammable. Corrosive.
R-PHRASES: 11 20/21/22 34
Highly flammable. Harmful by inhalation, in contact with skin
and if swallowed. Causes burns.
S-PHRASES: 16 26 36/37/39 45
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1 (self-classification)
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
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purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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