SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 07/DEC/2004
Version 1.8
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEPTANE, REAGENTPLUS(TM), 99%
Product Number H2198
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HEPTANE 142-82-5 205-563-8 601-008-00-2
Formula C7H16
Molecular Weight 100.21 AMU
Synonyms Dipropyl methane * Eptani (Italian) *
Gettysolve-C * Heptan (Polish) * n-Heptane *
Heptane (ACGIH:OSHA) * Heptanen (Dutch) *
n-Heptane (OSHA) * Heptyl hydride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Irritating to skin. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment. Harmful: may cause lung damage if swallowed. Vapors
may cause drowsiness and dizziness.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Use water spray to cool fire-exposed containers.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place. Handle and
store under nitrogen.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
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Poland NDS 1200 MG/M3
Poland NDSCh 2000 MG/M3
Poland NDSP -
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 2,085 mg/m3
500 ppm
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 820 mg/m3
200 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 2,000 mg/m3
500 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 800 mg/m3
200 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 1,600 mg/m3
400 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL LTEL 1,600 mg/m3
400 ppm
OEL STEL 500 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 98 - 99 藲C
MP/MP Range -91 藲C
Flash Point -4 藲C Method: closed cup
Flammability N/A
Autoignition Temp 223 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.1 %
Upper: 7 %
Vapor Pressure 40 mmHg 20 藲C
SG/Density 0.683 g/cm3
Partition Coefficient Log Kow: > 3
Viscosity N/A
Vapor Density 3.5 g/l
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Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.02 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MI7700000
ACUTE TOXICITY
LC50
Inhalation
Rat
103,000 mg/m3
4H
LD50
Intravenous
Mouse
222 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged or repeated exposure to skin causes defatting and
dermatitis. CNS depression. Narcotic effect. Damage to the lungs.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Heart. Lungs. Ears.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
12 - Ecological Information
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BIOACCUMULATION POTENTIAL: Indication of
bioaccumulation.
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Carassius auratus (Goldfish)
Time: 24 h
Value: 4 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 1.5 mg/l
ADDITIONAL ECOLOGICAL INFORMATION
BOD: 3.5 %
BOD5: 55 %
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1206
Class: 3
PG: II
Proper Shipping Name: Heptane
IMDG
UN#: 1206
Class: 3
PG: II
Proper Shipping Name: Heptanes
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1206
Class: 3
PG: II
Proper Shipping Name: Heptanes
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 601-008-00-2
NOTA: C, 4, 6
INDICATION OF DANGER: F Xn N
Highly Flammable. Harmful. Dangerous for the environment.
R-PHRASES: 11 38 50/53 65 67
Highly flammable. Irritating to skin. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment. Harmful: may cause lung damage if swallowed.
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Vapors may cause drowsiness and dizziness.
S-PHRASES: 9 16 29 33 60 61 62
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Do not empty into drains.
Take precautionary measures against static discharges. This
material and its container must be disposed of as hazardous
waste. Avoid release to the environment. Refer to special
instructions/safety data sheets. If swallowed, do not induce
vomiting: seek medical advice immediately and show this
container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 5
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 1190
YL-group: 3
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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