SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 13/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEXACHLOROBENZENE, 99%
Product Number 171050
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HEXACHLOROBENZENE 118-74-1 204-273-9 602-065-00-6
Formula C6Cl6
Molecular Weight 284.78 AMU
Synonyms Amatin * Anticarie * Bunt-cure * Bunt-no-more *
CEKU C.B. * CO-OP Hexa * Esaclorobenzene
(Italian) * Granox NM * HCB * Hexa C.B. *
Hexachlorbenzol (German) * Hexachlorobenzene
(ACGIH) * Julin's carbon chloride * NO Bunt * NO
Bunt 40 * NO Bunt 80 * NO Bunt liquid *
Pentachlorophenyl chloride * Perchlorobenzene *
Phenyl perchloryl * RCRA waste number U127 *
Saatbeizfungizid (German) * Sanocid * Sanocide *
Smut-Go * Snieciotox
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Also toxic: danger of serious damage to health
by prolonged exposure if swallowed. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
Carc. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 0.5 MG/M3
Poland NDSCh -
Poland NDSP -
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EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.025 mg/m3
Remarks: HK
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 323 - 326 藲C 760 mmHg
MP/MP Range 227 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DA2975000
ACUTE TOXICITY
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LD50
Oral
Rat
10000 mg/kg
LC50
Inhalation
Rat
3,600 mg/m3
LD50
Oral
Mouse
4000 mg/kg
LC50
Inhalation
Mouse
4,000 mg/m3
LD50
Oral
Cat
1700 mg/kg
LC50
Inhalation
Cat
1,600 mg/m3
LD50
Oral
Rabbit
2600 mg/kg
LC50
Inhalation
Rabbit
1,800 mg/m3
LD50
Oral
Guinea pig
> 3000 mg/kg
LD50
Oral
Quail
> 6400 mg/kg
LD50
Oral
Mammal
> 5000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Change in motor activity (specific assay).
SENSITIZATION
Sensitization: Causes photosensitivity. Exposure to light can
result in allergic reactions resulting in dermatologic lesions,
which can vary from sunburnlike responses to edematous,
vesiculated lesions, or bullae
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ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors. Blood:Leukemia
Mouse
Route of Application: Oral
Exposure Time: 83W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Blood:Lymphomas including Hodgkin's disease.
Hamster
Route of Application: Oral
Exposure Time: 18W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Endocrine:Thyroid tumors.
Hamster
Route of Application: Oral
Exposure Time: 80W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Hamster
Route of Application: Oral
Exposure Time: 80W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Oral
Exposure Time: 30W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Biochemical:Metabolism (intermediary): Porphyrin including bile
pigments.
Rat
Route of Application: Oral
Exposure Time: 90W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
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IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Mouse
1 GM/KG
Oral
Other mutation test systems
Hamster
6 MG/L
Cell Type: lung
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 40 MG/KG
Route of Application: Oral
Exposure Time: (10-13D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 6450 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/21D POST)
Result: Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow). Specific
Developmental Abnormalities: Immune and reticuloendothelial
system.
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (7-16D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Urogenital system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 556 MG/KG
Route of Application: Oral
Exposure Time: (96D PRE-21D POST)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rat
Dose: 88 MG/KG
Route of Application: Oral
Exposure Time: (70D MALE/70D PRE-22D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 812 MG/KG
Route of Application: Oral
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Exposure Time: (MULTIGENERATIONS)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rat
Dose: 212 MG/KG
Route of Application: Oral
Exposure Time: (14D PRE-17D POST)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Mouse
Dose: 600 MG/KG
Route of Application: Oral
Exposure Time: (6-17D PREG)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4). Effects on Newborn:
Biochemical and metabolic.
Species: Mouse
Dose: 625 MG/KG
Route of Application: Oral
Exposure Time: (8-12D PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Viability
index (e.g., # alive at day 4 per # born alive).
Species: Monkey
Dose: 910 UG/KG
Route of Application: Oral
Exposure Time: (13W PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Mammal
Dose: 27562 UG/KG
Route of Application: Oral
Exposure Time: (66D PRE-28D POST)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
CMR CAT.: Carc. Cat.2
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2729
Class: 6.1
PG: III
Proper Shipping Name: Hexachlorobenzene
IMDG
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UN#: 2729
Class: 6.1
PG: III
Proper Shipping Name: Hexachlorobenzene
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2729
Class: 6.1
PG: III
Proper Shipping Name: Hexachlorobenzene
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-065-00-6
NOTA: E
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 45 48/25 50/53
May cause cancer. Also toxic: danger of serious damage to
health by prolonged exposure if swallowed. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
S-PHRASES: 53 45 60 61
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible). This material and its container must be
disposed of as hazardous waste. Avoid release to the
environment. Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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