SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 27/JUL/2005
Version 1.7
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEXANE, REAGENTPLUS, >=99%
Product Number 139386
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
N-HEXANE 110-54-3 203-777-6 601-037-00-0
Formula C6H14
Molecular Weight 86.18 AMU
Synonyms Esani (Italian) * Gettysolve-B * Heksan (Polish)
* n-Hexane (ACGIH:OSHA) * Hexanen (Dutch) *
Hexyl hydride * NCI-C60571
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Irritating to skin. Harmful: danger of serious
damage to health by prolonged exposure through inhalation.
Possible risk of impaired fertility. Harmful: may cause lung
damage if swallowed. Vapors may cause drowsiness and dizziness.
Toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
Repr. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions. Vapor may travel considerable distance to
source of ignition and flash back.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
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EXPOSURE LIMITS
Country Source Type Value
Poland NDS 100 MG/M3
Poland NDSCh 400 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 90 mg/m3
25 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 180 mg/m3
50 ppm
Remarks: 4
Remarks: Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 90 mg/m3
25 ppm
Remarks: R
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level90 mg/m3
25 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 180 mg/m3
50 ppm
Remarks: M C H*
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 72 mg/m3
20 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 7
BP/BP Range 68 - 70 藲C
MP/MP Range -95 藲C
Flash Point -26 藲C Method: closed cup
Flammability N/A
Autoignition Temp 234 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.2 %
Upper: 7.7 %
Vapor Pressure 132 mmHg 20 藲C
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SG/Density 0.659 g/cm3
Partition Coefficient Log Kow: 3.9 - 4.11
Viscosity 32 Pas 25 藲C
Vapor Density 3 g/l
Saturated Vapor Conc. N/A
Evaporation Rate 15.8
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.01 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents Incompatible with: chlorine,
fluorine, and magnesium perchlorate.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MN9275000
ACUTE TOXICITY
LD50
Oral
Rat
25000 mg/kg
LC50
Inhalation
Rat
48,000 ppm
4H
IRRITATION DATA
Eyes
Rabbit
10 mg
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged or repeated contact with skin can cause defatting and
dermatitis. Contact with eyes can cause redness, tearing, and
blurred vision. Ingestion may cause gastrointestinal irritation.
Can cause CNS depression. Exposure can cause: Lung irritation,
chest pain, and edema which may be fatal. Headache, dizziness,
drowsiness, incoordination, slowed reaction time, slurred
speech, giddiness and unconsciousness.
ROUTE OF EXPOSURE
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Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Peripheral nervous system. Kidneys. Testes.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Inhalation
Exposure Time: 4H/59W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Tumorigenic
Effects: Testicular tumors.
Mouse
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Hamster
500 MG/L
Cell Type: fibroblast
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 5000 PPM/20H
Route of Application: Inhalation
Exposure Time: (6-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 238 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 10000 PPM/7H
Route of Application: Inhalation
Exposure Time: (15D PRE/1-18D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 1000 PPM/6H
Route of Application: Inhalation
Exposure Time: (8-16D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
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12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 3,878 mg/l
Test Type: EC50 Algae
Species: Chlorella vulgaris
Time: 3 h
Value: 12,840 mg/l
Test Type: EC50 Algae
Species: SKELETOMA
Time: 8 h
Value: 0.3 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1208
Class: 3
PG: II
Proper Shipping Name: Hexane
IMDG
UN#: 1208
Class: 3
PG: II
Proper Shipping Name: Hexanes
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1208
Class: 3
PG: II
Proper Shipping Name: Hexanes
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 601-037-00-0
NOTA: 4,6
INDICATION OF DANGER: F Xn N
Highly Flammable. Harmful. Dangerous for the environment.
R-PHRASES: 11 38 48/20 62 65 67 51/53
Highly flammable. Irritating to skin. Harmful: danger of
serious damage to health by prolonged exposure through
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inhalation. Possible risk of impaired fertility. Harmful: may
cause lung damage if swallowed. Vapors may cause drowsiness and
dizziness. Toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S-PHRASES: 9 16 29 33 36/37 61 62
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Do not empty into drains.
Take precautionary measures against static discharges. Wear
suitable protective clothing and gloves. Avoid release to the
environment. Refer to special instructions/safety data sheets.
If swallowed, do not induce vomiting: seek medical advice
immediately and show this container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 10266
YL-group: 5
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
Declaration Number: 7382
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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