SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/OCT/2005
Date Updated: 16/MAR/2004
Version 1.2
According to 91/155/EEC
1 - Product and Company Information
Product Name HEPARIN FROM PORCINE INTESTINAL MUCOSA
Product Number H4784
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HEPARIN 9041-08-1 None None
Synonyms ALFA 87-81 * ALFA 87-120 * ALFA 87-163 * ALFA
87-198 * ALFA 87-247 * Dalteparin sodium *
Depo-Heparin * Enoxaparin sodium * Inno-Hep *
Hed-heparin * Heparin sodium * Hepathrom * Kabi
2165 * LHN 1 * Liquaemin sodium * Liquemin *
Minolteparin sodium * Normiflo * Parnaparin
sodium * PK 10169 * Pularin * Reviparin sodium *
Ro 11 * RP 54563 * Sodium acid heparin * Sodium
heparin * Sodium heparinate * Tinzaparin sodium
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EEC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure. Do not use if skin is cut or scratched. Wash
thoroughly after handling.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Very faintly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
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Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:50 mg/ml H2O clear,
faintly yellow
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Sodium/sodium oxides, Sulfur
oxides, Nitrogen oxides Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MI0850000
ACUTE TOXICITY
LD50 LD50
Oral Oral
Rat Rat
>779000 IU/KG >779000 IU/KG
LD50 LD50
Subcutaneous Subcutaneous
Rat Rat
46715 IU/KG 46715 IU/KG
LD50 LD50
Intravenous Intravenous
Rat Rat
391821 IU/KG 391821 IU/KG
LD50 LD50
Oral Oral
Mouse Mouse
> 5000 mg/kg > 5000 mg/kg
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LD50 LD50
Intraperitoneal Intraperitoneal
Mouse Mouse
>2500 MG/KG >2500 MG/KG
LD50 LD50
Subcutaneous Subcutaneous
Mouse Mouse
>2500 MG/KG >2500 MG/KG
LD50 LD50
Intravenous Intravenous
Mouse Mouse
2800 MG/KG 2800 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Convulsions or effect on seizure threshold.
LD50 LD50
Intravenous Intravenous
Dog Dog
1 GM/KG 1 GM/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Convulsions or effect on seizure threshold.
SIGNS AND SYMPTOMS OF EXPOSURE
Heparin and its salts act as anticoagulants subcutaneously or
intravenously.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Blood.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
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15 - Regulatory Information
Not hazardous according to Directive 67/548/EEC.
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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