SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name METHYL SALICYLATE, 99+%
Product Number 240826
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
METHYL SALICYLATE 119-36-8 204-317-7 None
Formula C8H8O3
Molecular Weight 152.15 AMU
Synonyms o-Anisic acid * Benzoic acid, 2-hydroxy-, methyl
ester * Betula * Betula oil * Exagien *
Flucarmit * Gaultheria oil, artificial *
Gaultheria oil * o-Hydroxybenzoic acid, methyl
ester * 2-Hydroxybenzoic acid methyl ester *
Methylester kyseliny salicylove (Czech) * Methyl
o-hydroxybenzoate * Methyl salicylate * Natural
wintergreen oil * Oil of wintergreen * Salicylic
acid, methyl ester * Synthetic birch sweet oil *
Synthetic wintergreen oil * Teaberry oil *
Wintergreen oil * Wintergreen oil, synthetic
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes, respiratory system and
skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Heat and light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
ALDRICH - 240826 www.sigma-aldrich.com Page 2
Appearance Physical State: Clear liquid
Color: Slightly yellow-green
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 219 - 221 藲C
MP/MP Range -8 - -7 藲C
Flash Point 96 藲C Method: closed cup
Flammability N/A
Autoignition Temp 453 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 1 mmHg 54 藲C
SG/Density 1.184 g/cm3
Partition Coefficient Log Kow: 2.55
Viscosity N/A
Vapor Density 5.26 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Other Solvents: ETHANOL, GLACIAL ACETIC ACID
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light. Heat.
Materials to Avoid: Strong bases, Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: VO4725000
ACUTE TOXICITY
LDLO
Oral
Man
101 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Gastrointestinal:Nausea or vomiting.
LDLO
Oral
Man
1329 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
ALDRICH - 240826 www.sigma-aldrich.com Page 3
Behavioral:Coma. Blood: Hemorrhage.
LDLO
Oral
Child
228 mg/kg
Remarks: Lungs, Thorax, or Respiration:Dyspnea.
Gastrointestinal:Nausea or vomiting.
LDLO
Oral
Child
700 mg/kg
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage).
Behavioral:General anesthetic. Lungs, Thorax, or
Respiration:Dyspnea.
LDLO
Oral
Woman
355 mg/kg
Remarks: Behavioral:Coma. Lungs, Thorax, or
Respiration:Respiratory stimulation. Gastrointestinal:Nausea or
vomiting.
LDLO
Oral
Infant
1480 mg/kg
Remarks: Lungs, Thorax, or Respiration:Respiratory stimulation.
Gastrointestinal:Nausea or vomiting.
LDLO
Oral
Human
506 mg/kg
LD50
Oral
Rat
887 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
LD50
Oral
Mouse
1110 mg/kg
LD50
Oral
Dog
2100 mg/kg
Remarks: Lungs, Thorax, or Respiration:Other changes.
Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
LD50
Oral
Rabbit
1300 mg/kg
ALDRICH - 240826 www.sigma-aldrich.com Page 4
LD50
Oral
Guinea pig
700 mg/kg
IRRITATION DATA
Skin
Rabbit
500 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Skin
Guinea pig
100 %
Remarks: Severe irritation effect
Eyes
Guinea pig
100 %
Remarks: Severe irritation effect
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Mild chronic salicylate intoxication is termed salicylism.
Symptoms include: headache, dizziness, ringing in the ears,
difficulty in hearing, dimness of vision, mental confusion,
lassitude, drowsiness, sweating, thirst, hyperventilation,
nausea, vomiting, and occasionally diarrhea. A more severe
degree of salicylate intoxication is characterized by more
pronounced CNS disturbances (including generalized convulsions
and coma), skin eruptions, and marked alterations in acid-base
balance.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Readily absorbed through skin. May be harmful
if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Liver. Ears. Kidneys. Eyes.
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 500 MG/KG
Route of Application: Intraperitoneal
ALDRICH - 240826 www.sigma-aldrich.com Page 5
Exposure Time: (11-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Urogenital system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Central nervous system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Hepatobiliary
system. Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue).
Species: Hamster
Dose: 1750 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Hamster
Dose: 5250 MG/KG
Route of Application: Skin
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 36450 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Viability
index (e.g., # alive at day 4 per # born alive). Effects on
Newborn: Weaning or lactation index (e.g., # alive at weaning
per # alive at day 4).
Species: Rat
Dose: 400 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
ALDRICH - 240826 www.sigma-aldrich.com Page 6
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system
and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - 240826 www.sigma-aldrich.com Page 7
|