SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 08/AUG/2005
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEXAFLUOROACETONE TRIHYDRATE, 98%
Product Number 139238
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HEXAFLUOROACETONE TRIHYDRATE 34202-69-2 211-676-3 None
Formula C3F6O
Molecular Weight 220.07 AMU
Synonyms Acetone, hexafluoro-, trihydrate * GC 7787 *
Hexafluoroacetone trihydrate * HFA
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed. Causes
burns. Possible risk of harm to the unborn child.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
SPECIAL RISKS
Specific Hazard(s): Water reactive material. Emits toxic fumes
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.7 mg/m3
0.1 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
ALDRICH - 139238 www.sigma-aldrich.com Page 2
TRGS 900 OEL 0.7 mg/m3
Remarks: H,NL
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range -26 藲C 106 - 108 藲C 760 mmHg
MP/MP Range -129 藲C 18 - 21 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 4523.75 mmHg 4525 mm21 藲C 21.1 藲C
Hg
SG/Density 1.32 g/cm3 1.606 g/c
m3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 1.65 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Readily hydrolyzed.
Conditions to Avoid: Do not allow water to enter container.
Materials to Avoid: Reacts violently with water., Strong oxidizing
agents
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen fluoride.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
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RTECS NUMBER: UC2700000
ACUTE TOXICITY
LD50
Oral
Rat
190 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
LD50
Skin
Rabbit
113 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Skin and Appendages:Skin: After topical exposure:Primary
irritation.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause: Nausea, dizziness, and headache.
CNS depression.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Readily absorbed through skin. Toxic if
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Toxic if inhaled. Material is extremely destructive
to the tissue of the mucous membranes and upper respiratory
tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Testes. Thymus.
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 275 MG/KG
Route of Application: Skin
Exposure Time: (6-16D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear.
Species: Rat
Dose: 55 MG/KG
Route of Application: Skin
Exposure Time: (6-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system. Specific Developmental Abnormalities:
Other developmental abnormalities.
Species: Rat
Dose: 11 MG/KG
Route of Application: Skin
Exposure Time: (6-16D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
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CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Data from animal studies have shown reduced sperm
formation, testicular atrophy in exposed dogs, rats and mice,
and nonfunctioning ovaries in mice.
Species: Rat
Dose: 275 MG/KG
Route of Application: Skin
Exposure Time: (6-16D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetal death. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2552
Class: 6.1
PG: II
Proper Shipping Name: Hexafluoroacetone hydrate
IMDG
UN#: 2552
Class: 6.1
PG: II
Proper Shipping Name: Hexafluoroacetone hydrate
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2552
Class: 6.1
PG: II
Proper Shipping Name: Hexafluoroacetone hydrate
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 23/24/25 34 63
Toxic by inhalation, in contact with skin and if swallowed.
Causes burns. Possible risk of harm to the unborn child.
S-PHRASES: 26 36/37/39 45
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
ALDRICH - 139238 www.sigma-aldrich.com Page 5
or if you feel unwell, seek medical advice immediately (show
the label where possible).
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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