SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/JUN/2004
Date Updated: 17/JUN/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEXAMETHYLPHOSPHORAMIDE, 99%
Product Number H11602
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HEXAMETHYLPHOSPHORAMIDE 680-31-9 211-653-8 015-106-00-2
Formula C6H18N3OP
Molecular Weight 179.2 AMU
Synonyms Eastman Inhibitor HPT * ENT 50882 * Hempa *
Hexametapol * Hexamethylfosforamid (Czech) *
Hexamethyl phosphoramide (ACGIH) *
Hexamethylphosphoric acid triamide *
Hexamethylphosphoric triamide *
N,N,N,N,N,N-Hexamethylphosphoric triamide *
Hexamethylphosphorotriamide *
Hexamethylphosphotriamide *
Hexmethylphosphoramide * HMPA * HMPT * HPT *
Phosphoric acid hexamethyltriamide * Phosphoric
tris(dimethylamide) * Phosphoryl
hexamethyltriamide *
Tri(dimethylamino)phosphineoxide *
Tris-(dimethylamid) kyseliny fosforecne (Czech)
* Tris(dimethylamino)phosphine oxide *
Tris(dimethylamino)phosphorus oxide
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. May cause heritable genetic damage.
Carc. Cat.2 Muta. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
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Country Source Type Value
Poland NDS 0.05 mg/m3
Poland NDSCh -
Poland NDSP
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
Remarks: H K
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 230 - 232 掳C 740 mmHg
MP/MP Range 7 掳C
Flash Point 144 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.03 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 6.18 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Thermal decomposition may produce toxic fumes of phosphorus oxides
and/or phosphine.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
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RTECS NUMBER: TD0875000
ACUTE TOXICITY
LD50
Oral
Rat
2650 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Kidney, Ureter, Bladder:Hematuria. Kidney, Ureter,
Bladder:Incontinence.
LD50
Oral
Mouse
2400 mg/kg
LD50
Intraperitoneal
Mouse
1600 MG/KG
LD50
Intravenous
Mouse
800 MG/KG
LD50
Skin
Rabbit
2600 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Lungs, Thorax, or Respiration:Dyspnea.
LD50
Oral
Guinea pig
1600 mg/kg
LD50
Skin
Guinea pig
1175 mg/kg
LD50
Oral
Chicken
835 mg/kg
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage).
Behavioral:Ataxia.
LD50
Oral
Quail
1000 mg/kg
IRRITATION DATA
Skin
Guinea pig
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0.05 ml
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys. Lungs. Male reproductive system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Inhalation
Exposure Time: 52W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 35W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 26W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/1Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 39W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/26W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
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Exposure Time: 6H/43W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/52W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/26W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/52W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Result: May alter genetic material.
other insects
200 UG
Parenteral
sperm
Human
80 UG/L
Cell Type: liver
Morphological transformation.
Human
125 MG/L
Cell Type: HeLa cell
Unscheduled DNA synthesis
Human
156 MG/L
Cell Type: fibroblast
Unscheduled DNA synthesis
Human
500 MG/L
Cell Type: lymphocyte
Cytogenetic analysis
Human
5 MMOL/L
Cell Type: leukocyte
Cytogenetic analysis
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Rat
1800 MG/KG
Intraperitoneal
Micronucleus test
Rat
100 MG/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
1 GM/KG
Cell Type: ovary
Body fluid assay
Rat
1800 MG/KG
Intraperitoneal
Cytogenetic analysis
Rat
2 GM/L
Cell Type: liver
Sister chromatid exchange
Mouse
600 MG/KG
Oral
Micronucleus test
Mouse
1280 MG/KG
Intraperitoneal
Micronucleus test
Mouse
3 ML/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
1 GM/L
Cell Type: Embryo
Morphological transformation.
Mouse
1700 UG/KG
Intraperitoneal
Sister chromatid exchange
Mouse
250 MG/KG
Intraperitoneal
12H
Dominant lethal test
Mouse
3 GM/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
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400 MG/L
Cell Type: Embryo
Morphological transformation.
Hamster
2500 UG/L
Cell Type: kidney
Morphological transformation.
Hamster
2 MG/L
Cell Type: liver
Cytogenetic analysis
Hamster
2 GM/L
Cell Type: lung
Cytogenetic analysis
Hamster
5 GM/L
Cell Type: ovary
Sister chromatid exchange
Hamster
5 MMOL/L
Cell Type: lung
Sister chromatid exchange
Hamster
10 MG/L
Cell Type: liver
SLN
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 2430 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Rat
Dose: 2 GM/KG
Route of Application: Oral
Exposure Time: (1D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 43750 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (5W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
SWEDISH OE CARCINOGEN: Substances which according to 21搂, AFS
2000:3, no use allowed.
12 - Ecological Information
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3082
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, liquid, n.o.s.
IMDG
UN#: 3082
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, liquid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3082
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, liquid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 015-106-00-2
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45 46
May cause cancer. May cause heritable genetic damage.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
ALDRICH - H11602 www.sigma-aldrich.com Page 9
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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