SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 15/JUN/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE
Product Number B4388
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-BROMO-2-CHLORO-1,1,1-TRIFLUOROET 151-67-7 205-796-5 None
HANE
Formula C2HBrClF3
Molecular Weight 197.39 AMU
Synonyms Bromochlorotrifluoroethane *
1-Bromo-1-chloro-2,2,2-trifluoroethane *
2-Bromo-2-chloro-1,1,1-trifluoroethane *
Chalothane * Ethane,
1-bromo-1-chloro-2,2,2-trifluoro- * Fluorotane *
Fluothane * Ftorotan (Russian) * Halotan *
Halothane (ACGIH) * Halsan * Narcotane *
Narcotann NE-spofa (Russian) *
1,1,1-Trifluoro-2-bromo-2-chloroethane *
1,1,1-Trifluoro-2-chloro-2-bromoethane *
2,2,2-Trifluoro-1-chloro-1-bromoethane
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause harm to the unborn child. Risk of serious damage to
eyes. Irritating to respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 40 MG/M3
Poland NDSCh 100 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 40 mg/m3
SIGMA - B4388 www.sigma-aldrich.com Page 2
5 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 40 mg/m3
5 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 0.2 mg/m3
0.02 ppm
Remarks: R
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level40 mg/m3
5 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 40 mg/m3
5 ppm
Remarks: M B
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 82 mg/m3
10 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 50 掳C 760 mmHg
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 232.65 mmHg 20 掳C
SG/Density 1.872 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
SIGMA - B4388 www.sigma-aldrich.com Page 3
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to light.
Materials to Avoid: Strong oxidizing agents, Rubber, Plastics,
Chemically active metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas, Hydrogen bromide gas, Hydrogen fluoride.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: KH6550000
ACUTE TOXICITY
LD50
Oral
Rat
6,700 mg/kg
LCLO
Inhalation
Human
7,000 ppm
3H
Remarks: Liver:Hepatitis (hepatocellular necrosis), diffuse.
Gastrointestinal:Nausea or vomiting. Nutritional and Gross
Metabolic:Changes in:Body temperature increase.
LDLO
Intravenous
Man
129 MG/KG
Remarks: Behavioral:General anesthetic. Cardiac: Change in rate.
Lungs, Thorax, or Respiration:Cyanosis.
LD50
Oral
Rat
5680 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Antipsychotic.
LC50
Inhalation
Rat
29,000 ppm
LC50
Inhalation
Mouse
98,000 mg/m3
2H
SIGMA - B4388 www.sigma-aldrich.com Page 4
Remarks: Brain and Coverings:Other degenerative changes.
Liver:Other changes. Kidney, Ureter, Bladder:Other changes.
LD50
Oral
Guinea pig
6000 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Antipsychotic.
IRRITATION DATA
Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Causes a fall in blood pressure. Exposure can cause: Narcotic
effect. Dizziness. Drowsiness. Confusion. Unconsciousness.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys. Liver. Central nervous system. Cardiovascular system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
CHRONIC EXPOSURE - MUTAGEN
Human
1 PPH/48H-C
Cell Type: lymphocyte
Cytogenetic analysis
Rat
4 MMOL/KG
Oral
Micronucleus test
Rat
1000 PPM
Inhalation
2H
Unscheduled DNA synthesis
Rat
10 GM/KG
Oral
Unscheduled DNA synthesis
Mouse
1 PPH/1H
Inhalation
SIGMA - B4388 www.sigma-aldrich.com Page 5
Other mutation test systems
Mouse
8000 PPM
Inhalation
24H
DNA inhibition
Mouse
1000 PPM
Cell Type: fibroblast
Cytogenetic analysis
Hamster
1 PPH
Cell Type: fibroblast
Other mutation test systems
Hamster
1 PPH/48H-C
Cell Type: lung
Cytogenetic analysis
Chicken
10 MG
Parenteral
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 500 ppm/4H 500 ppm/4HR
Route of Application: Inhalation
Exposure Time: Daily 9 weeks
Species: Mouse
Dose: 500 ppm/ 2H 500 ppm/ 2HR
Route of Application: Inhalation
Exposure Time: Daily 9 weeks
Species: Mouse
Dose: 1000 ppm/4HR 1000 ppm/4H
Route of Application: Inhalation
Exposure Time: Daily 9 weeks
Species: Rat
Dose: 8000 PPM/12H
Route of Application: Inhalation
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 1600 PPM/8H
Route of Application: Inhalation
Exposure Time: (1-21D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 10 PPM/8H
Route of Application: Inhalation
Exposure Time: (1-22D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
SIGMA - B4388 www.sigma-aldrich.com Page 6
(including somatic cell genetic material). Specific
Developmental Abnormalities: Central nervous system.
Species: Rat
Dose: 10 PPM/8H
Route of Application: Inhalation
Exposure Time: (1-22D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material). Specific
Developmental Abnormalities: Urogenital system.
Species: Mouse
Dose: 1 PPH/3H
Route of Application: Inhalation
Exposure Time: (13D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system. Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Mouse
Dose: 3000 PPM/4H
Route of Application: Inhalation
Exposure Time: (9W PRE/1-17D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 100 PPM/8H
Route of Application: Inhalation
Exposure Time: (2-22D PREG/30D POST)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 8000 PPM/6H
Route of Application: Inhalation
Exposure Time: (7-9D PREG)
Result: Effects on Fertility: Abortion.
Species: Mouse
Dose: 3000 PPM/4H
Route of Application: Inhalation
Exposure Time: (9W PRE/1-21D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Fertility: Other
measures of fertility
Species: Mouse
Dose: 1000 PPM/4H
Route of Application: Inhalation
Exposure Time: (9W PRE/1-21D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Mouse
Dose: 14000 PPM/1H
Route of Application: Inhalation
Exposure Time: (8-10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
SIGMA - B4388 www.sigma-aldrich.com Page 7
Species: Mouse
Dose: 15000 PPM/40M
Route of Application: Inhalation
Exposure Time: (3W PRE)
Result: Maternal Effects: Other effects. Effects on Newborn:
Weaning or lactation index (e.g., # alive at weaning per # alive
at day 4). Effects on Newborn: Other postnatal measures or
effects.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
UN#: 3334
Class: 9
Proper Shipping Name: Aviation Regulated Liquid, N.O.S.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 61 41 37/38
May cause harm to the unborn child. Risk of serious damage to
eyes. Irritating to respiratory system and skin.
S-PHRASES: 53 23 26 36/37 45
Avoid exposure - obtain special instructions before use. Do not
breathe vapor. In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice. Wear suitable
protective clothing and gloves. In case of accident or if you
feel unwell, seek medical advice immediately (show the label
where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
SIGMA - B4388 www.sigma-aldrich.com Page 8
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA - B4388 www.sigma-aldrich.com Page 9
|