SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 12/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETAMIDE
Product Number 00160
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETAMIDE 60-35-5 200-473-5 616-022-00-4
Formula C2H5NO
Molecular Weight 59.07 AMU
Synonyms Acetic acid amide * Acetimidic acid * Amid
kyseliny octove (Czech) * Ethanamide *
Methanecarboxamide * NCI-C02108
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Limited evidence of a carcinogenic effect.
Carc. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off leak if there is no risk.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
ENVIRONMENTAL PRECAUTION(S)
Avoid contaminating water supply. Avoid contaminating sewers and
waterways with this material.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
OSHA. PEL TWA 10 ppm
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EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 25 mg/m3
10 ppm
Remarks: K
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level25 mg/m3
10 ppm
Remarks: K
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid.
Color: Colorless
Form: Crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 221 掳C 760 mmHg
MP/MP Range 79 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 1 mmHg 65 掳C
SG/Density 1.159 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Sensitive to moisture.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases, Strong reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Ammonia.
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HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AB4025000
ACUTE TOXICITY
LD50
Oral
Rat
7,000 mg/kg
CAS # 60-35-5
LD50
Oral
Rat
3,310 mg/kg
CAS # 64-19-7
LD50
Skin
Rabbit
1,060 mg/kg
CAS # 64-19-7
LC50
Inhalation
Rat
16,000 ppm
CAS # 64-19-7
LD50
Oral
Rat
7000 mg/kg
LD50
Intraperitoneal
Rat
10300 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Subcutaneous
Rat
10 GM/KG
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage). Autonomic
Nervous System:Smooth muscle relaxant (mechanism undefined,
spasmolytic). Cardiac: Change in rate.
LD50
Intravenous
Rat
12500 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation.
LD50
Oral
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Mouse
12900 mg/kg
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation.
LD50
Intraperitoneal
Mouse
1 GM/KG
LD50
Subcutaneous
Mouse
8300 MG/KG
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage). Autonomic
Nervous System:Smooth muscle relaxant (mechanism undefined,
spasmolytic). Cardiac: Change in rate.
LD50
Intravenous
Mouse
10 GM/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation.
LD50
Intravenous
Rabbit
7500 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 1Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Nutritional and Gross Metabolic:Weight loss or
decreased weight gain.
Mouse
Route of Application: Oral
Exposure Time: 1Y
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Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Tumors. Blood:Lymphomas including Hodgkin's disease.
Rat
Route of Application: Oral
Exposure Time: 52W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Rat
5 MG/L
Cell Type: Embryo
Morphological transformation.
Mouse
3390 UMOL/KG
Oral
Micronucleus test
Mouse
10 PPH
Cell Type: Ascites tumor
Other mutation test systems
Hamster
1 MG/L
Cell Type: Embryo
Morphological transformation.
CHRONIC EXPOSURE - TERATOGEN
Species: Rabbit
Dose: 13 GM/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rabbit
Dose: 39 GM/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
CMR CAT.: Carc. Cat.3
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
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of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 616-022-00-4
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 40
Limited evidence of a carcinogenic effect.
S-PHRASES: 36/37
Wear suitable protective clothing and gloves.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 5
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
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Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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