SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 16/JUN/2004
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETIC ACID, 99.8%
Product Number 109088
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETIC ACID 64-19-7 200-580-7 607-002-00-6
Formula C2H4O2
Molecular Weight 60.05 AMU
Synonyms Acetic acid (ACGIH:OSHA) * Acetic acid, glacial
* Acide acetique (French) * Acido acetico
(Italian) * Azijnzuur (Dutch) * Essigsaeure
(German) * Ethanoic acid * Ethylic acid *
Glacial acetic acid * Kyselina octova (Czech) *
Methanecarboxylic acid * Octowy kwas (Polish) *
Vinegar acid
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Causes severe burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 15 MG/M3
Poland NDSCh 30 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
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Source Type Value
OEL TWA 25 mg/m3
10 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 25 mg/m3
10 ppm
Remarks: =1=
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 25 mg/m3
10 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level13 mg/m3
5 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 25 mg/m3
10 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 25 mg/m3
10 ppm
OEL STEL 37 mg/m3
15 ppm
Remarks: Indicative limit value
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
pH 2.4 Concentration: 60.05 g/l
BP/BP Range 117 - 118 掳C 760 mmHg
MP/MP Range 16.2 掳C
Flash Point 40 掳C Method: closed cup
Flammability N/A
Autoignition Temp 427 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 4 %
Upper: 19.9 %
Vapor Pressure 11.4 mmHg 20 掳C
SG/Density 1.06 g/cm3
Partition Coefficient Log Kow: -0.17
Viscosity N/A
Vapor Density 2.07 g/l
Saturated Vapor Conc. N/A
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Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 28.8 mN/m 10 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
Other Solvents: MISCIBLE WITH ALCOHOL,
ETHER GLYCEROL, ACETONE, BEN
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Protect from moisture.
Materials to Avoid: Oxidizing agents, Soluble carbonates and
phosphates, Hydroxides, Oxides, Metals, Peroxides, Permanganates,
Amines, Alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AF1225000
ACUTE TOXICITY
LD50
Oral
Rat
3310 mg/kg
LC50
Inhalation
Mouse
5,620 ppm
1H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Sense Organs and Special
Senses (Nose, Eye, Ear, and Taste):Eye:Other. Blood:Other
changes.
LD50
Intravenous
Mouse
525 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Skin
Rabbit
1060 UL/KG
IRRITATION DATA
Skin
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Human
50 mg
24H
Remarks: Mild irritation effect
Skin
Rabbit
525 mg
Remarks: Open irritation test
Skin
Rabbit
50 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
5 mg
30S
Remarks: Rinsed
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Ingestion or inhalation of concentrated acetic acid
causes damage to tissues of the respiratory and digestive
tracts. Symptoms include: hematemesis, bloody diarrhea, edema
and/or perforation of the esophagus and pylorus, hematuria,
anuria, uremia, albuminuria, hemolysis, convulsions, bronchitis,
pulmonary edema, pneumonia, cardiovascular collapse, shock, and
death. Direct contact or exposure to high concentrations of
vapor with skin or eyes can cause: erythema, blisters, tissue
destruction with slow healing, skin blackening, hyperkeratosis,
fissures, corneal erosion, opacification, iritis,
conjunctivitis, and possible blindness. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Teeth. Kidneys.
CONDITIONS AGGRAVATED BY EXPOSURE
Severe, acute pancreatitis may occur after ingestion of
concentrated acetic acid.
CHRONIC EXPOSURE - MUTAGEN
Human
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5 MMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Mouse
79279 UG/KG
Skin
Unscheduled DNA synthesis
Mouse
1201 MG/KG
Skin
Other mutation test systems
Hamster
10 MMOL/L
Cell Type: ovary
Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (18D POST)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 400 MG/KG
Route of Application: Intratesticular
Exposure Time: (1D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Time: 24 h
Value: 156 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 65 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 410 mg/l
Test Type: LC50 Fish
Species: Cyprinus carpio
Time: 48 h
Value: 49 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 79 - 88 mg/l
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2789
Class: 8
PG: II
Proper Shipping Name: Acetic acid, glacial
IMDG
UN#: 2789
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Acetic acid, glacial
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2789
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Acetic acid, glacial
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-002-00-6
NOTA: B
INDICATION OF DANGER: C
Corrosive.
R-PHRASES: 10 35
Flammable. Causes severe burns.
S-PHRASES: 26 36/37/39 45
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
Declaration Number: 66086
16 - Other Information
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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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