SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 20/JUL/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETALDEHYDE, 99+%, FCC (MINI-BULK)
Product Number W200360
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETALDEHYDE, FOR MANUFACTURING 75-07-0 200-836-8 605-003-00-6
Formula C2H4O
Molecular Weight 44.05 AMU
Synonyms Acetaldehyd (German) * Acetaldehyde (ACGIH:OSHA)
* Acetic aldehyde * Acetylaldehyde * Aldehyde
acetique (French) * Aldeide acetica (Italian) *
Ethanal * NCI-C56326 * Octowy aldehyd (Polish) *
RCRA waste number U001
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Extremely flammable. Irritating to eyes and respiratory system.
Limited evidence of a carcinogenic effect.
Carc. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Extremely flammable. Emits toxic fumes under
fire conditions. Vapor may travel considerable distance to
source of ignition and flash back.
Explosion Hazards: May explode when heated. Closed containers
may rupture and explode during runaway polymerization. Vapors
may form explosive mixtures with air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with an activated carbon adsorbent, take up and place in
closed containers. Transport outdoors. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Open carefully. Avoid all
contamination. Always open containers slowly to allow any excess
pressure to vent.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame. Store under nitrogen.
Store at 2-8掳C
SPECIAL REQUIREMENTS: May develop pressure. Air sensitive.
Refrigerate before opening.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
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GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 5 MG/M3
Poland NDSCh -
Poland NDSP 45
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 90 mg/m3
50 ppm
Remarks: =1=
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 45 mg/m3
25 ppm
Remarks: K
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level45 mg/m3
25 ppm
Remarks: K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 90 mg/m3
50 ppm
Remarks: D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 37 mg/m3
20 ppm
OEL STEL 92 mg/m3
50 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 21 掳C 760 mmHg
MP/MP Range -125 掳C
Flash Point -40 掳C Method: closed cup
Flammability N/A
Autoignition Temp 175 掳C
Oxidizing Properties N/A
Explosive Properties N/A
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Explosion Limits Lower: 4 %
Upper: 60 %
Vapor Pressure 2415.4 mmHg 55 掳C
SG/Density 0.785 g/cm3
Partition Coefficient Log Kow: 0.5
Viscosity N/A
Vapor Density 1.52 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Unstable.
Conditions to Avoid: Sensitive to air.
Materials to Avoid: Oxidizing agents, Reducing agents, Acids,
Nitric acid, Peroxides, Bases, Caustic soda, Amines, Ammonia,
Oxygen, Chemical contamination.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Oxidized readily in air to form unstable
peroxides that can lead to spontaneous explosion. May undergo
autopolymerization Uncontrolled polymerization can cause rapid
evolution of heat and increased pressure which can result in
violent rupture of storage vessels or containers.
11 - Toxicological Information
RTECS NUMBER: AB1925000
ACUTE TOXICITY
LD50
Oral
Rat
661 mg/kg
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Altered sleep time
(including change in righting reflex). Lungs, Thorax, or
Respiration:Dyspnea.
LC50
Inhalation
Rat
13,300 ppm
4H
Remarks: Behavioral:Excitement. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Subcutaneous
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Rat
640 MG/KG
Remarks: Behavioral:General anesthetic.
LD50
Oral
Mouse
900 mg/kg
LC50
Inhalation
Mouse
23,000 mg/m3
4H
LD50
Intraperitoneal
Mouse
500 MG/KG
LD50
Subcutaneous
Mouse
560 MG/KG
Remarks: Behavioral:General anesthetic.
LD50
Skin
Rabbit
3540 mg/kg
LC50
Inhalation
Hamster
17,000 ppm
4H
LD50
Intratracheal
Hamster
96 MG/KG
LC50
Inhalation
Mammal
20,100 mg/m3
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Excitement. Lungs, Thorax, or
Respiration:Dyspnea.
IRRITATION DATA
Skin
Rabbit
500 mg
Remarks: Mild irritation effect
Eyes
Human
50 ppm
15M
Skin
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Rabbit
500 mg
Remarks: Open irritation test
Eyes
Rabbit
40 mg
Remarks: Severe irritation effect
SENSITIZATION
Sensitization: Photosensitizer.
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Pulmonary edema. Effects may be delayed.
Nausea. Vomiting. Headache. Blurred vision. Unconsciousness.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation. Lachrymator.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Blood. Kidneys. Lungs. Cardiovascular system. Liver. Central
nervous system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Hamster
Route of Application: Inhalation
Exposure Time: 7H/52W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors. Lungs, Thorax, or Respiration:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/65W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
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1560 UMOL/L
Cell Type: lymphocyte
DNA damage
Human
3 MMOL/L
Cell Type: Other cell types
DNA damage
Human
30 MMOL/L
Cell Type: Other cell types
DNA inhibition
Human
30 MMOL/L
Cell Type: Other cell types
Other mutation test systems
Human
10 MMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
1000 PPM
72H
Cell Type: leukocyte
Cytogenetic analysis
Human
1200 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Human
40 UMOL/L
Cell Type: fibroblast
Sister chromatid exchange
Human
5 MMOL/L
Cell Type: fibroblast
Mutation in mammalian somatic cells.
Rat
500 UMOL/L
Cell Type: fibroblast
Micronucleus test
Rat
3 MMOL/L
3H
Cell Type: kidney
Morphological transformation.
Rat
100 UMOL/L
Cell Type: fibroblast
Morphological transformation.
Rat
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200 MMOL/L
Cell Type: liver
DNA damage
Rat
1000 PPM
Inhalation
6H/5D
DNA damage
Rat
500 MMOL/L
Cell Type: Other cell types
DNA damage
Rat
12500 UMOL/L
Cell Type: Other cell types
Other mutation test systems
Rat
1 MMOL/L
Cell Type: fibroblast
DNA inhibition
Rat
1 MMOL/L
Cell Type: fibroblast
Other mutation test systems
Rat
100 UMOL/L
Cell Type: fibroblast
Cytogenetic analysis
Mouse
95 MG/KG
Intraperitoneal
Micronucleus test
Mouse
10 MG/L
Cell Type: Embryo
Morphological transformation.
Mouse
15 NG/KG
Intraperitoneal
Sister chromatid exchange
Mouse
4 MMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
40 PPM
Cell Type: Embryo
Cytogenetic analysis
Hamster
500 UG/KG
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Intraperitoneal
Sister chromatid exchange
Hamster
30 UMOL/L
Cell Type: ovary
Sister chromatid exchange
Hamster
20 PPM
Cell Type: Embryo
SLN
Mammal
1 MOL/L
30M
Cell Type: lymphocyte
DNA damage
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 4800 MG/KG
Route of Application: Oral
Exposure Time: (1-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Respiratory system. Specific Developmental Abnormalities:
Hepatobiliary system.
Species: Rat
Dose: 5040 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Endocrine system.
Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 100 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Homeostasis
Species: Rat
Dose: 400 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 640 UG/KG
Route of Application: Intraperitoneal
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Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 5040 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 300 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-13D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse
Dose: 120 MG/KG
Route of Application: Intravenous
Exposure Time: (7-9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Mouse
Dose: 4 GM/KG
Route of Application: Intravenous
Exposure Time: (6D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Central nervous system.
CMR CAT.: Carc. Cat.3
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 31 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 48 mg/l
13 - Disposal Considerations
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SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1089
Class: 3
PG: I
Proper Shipping Name: Acetaldehyde
IMDG
UN#: 1089
Class: 3
PG: I
Proper Shipping Name: Acetaldehyde
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1089
Class: 3
PG: I
Proper Shipping Name: Acetaldehyde
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 605-003-00-6
INDICATION OF DANGER: F+ Xn
Extremely Flammable. Harmful.
R-PHRASES: 12 36/37 40
Extremely flammable. Irritating to eyes and respiratory system.
Limited evidence of a carcinogenic effect.
S-PHRASES: 16 33 36/37
Keep away from sources of ignition - no smoking. Take
precautionary measures against static discharges. Wear suitable
protective clothing and gloves.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 34666
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
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In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
Caution: for manufacturing, processing, or repacking. This
material is not sterile and has not been pyrogen-tested.
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