SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 12/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETIC ANHYDRIDE, 99+%
Product Number 110043
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETIC ANHYDRIDE 108-24-7 203-564-8 607-008-00-9
Formula C4H6O3
Molecular Weight 102.09 AMU
Synonyms Acetanhydride * Acetic acid, anhydride (9CI) *
Acetic anhydride (ACGIH:OSHA) * Acetic oxide *
Acetyl anhydride * Acetyl ether * Acetyl oxide *
Anhydride acetique (French) * Anhydrid kyseliny
octove (Czech) * Anidride acetica (Italian) *
Azijnzuuranhydride (Dutch) * Essigsaeureanhydrid
(German) * Ethanoic anhydrate * Octowy bezwodnik
(Polish)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation and if swallowed. Causes burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with an activated carbon adsorbent, take up and place in
closed containers. Transport outdoors. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS: Reacts violently with water.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 10 MG/M3
Poland NDSCh -
Poland NDSP 20 MG/M3
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EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 20 mg/m3
5 ppm
Remarks: L
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 20 mg/m3
5 ppm
Remarks: =1=
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 20 mg/m3
5 ppm
Remarks: T
EXPOSURE LIMITS - SWEDEN
Source Type Value
CLV (Ceili20 mg/m3
5 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 20 mg/m3
5 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 2.5 mg/m3
0.5 ppm
OEL STEL 10 mg/m3
2 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Odor: Pungent Acrid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 138 - 140 掳C 760 mmHg
MP/MP Range -73 掳C
Flash Point 49 掳C Method: closed cup
Flammability N/A
Autoignition Temp 332 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.7 %
Upper: 10.3 %
Vapor Pressure 4 mmHg 20 掳C
SG/Density 1.08 g/cm3
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Partition Coefficient N/A
Viscosity 0.91 Pas 20 掳C
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. 136 掳C
Solvent Content N/A
Water Content N/A
Surface Tension 32.7 mN/m 20 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly.
Other Solvents: BENZENE, CHLOROFORM
MISCIBLE WITH ALCOHOL, ETHER AC
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Do not allow water to enter container because
of violent reaction.
Materials to Avoid: Alcohols, Acids, Oxidizing agents, Bases,
Reducing agents, Finely powdered metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AK1925000
ACUTE TOXICITY
LD50
Oral
Rat
1780 mg/kg
LC50
Inhalation
Rat
1,000 ppm
4H
LD50
Skin
Rabbit
4 ML/KG
IRRITATION DATA
Skin
Rabbit
Remarks: Mild irritation effect
Eyes
Rabbit
Remarks: Severe irritation effect
Skin
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Rabbit
540 mg
Remarks: Open irritation test
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns. Lachrymator.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Time: 24 h
Value: 200 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 96 h
Value: 55 mg/l
Test Type: LC50 Fish
Species: other fish
Time: 48 h
Value: 265 - 279 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1715
Class: 8
PG: II
Proper Shipping Name: Acetic anhydride
IMDG
UN#: 1715
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Acetic anhydride
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Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1715
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Acetic anhydride
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-008-00-9
INDICATION OF DANGER: C
Corrosive.
R-PHRASES: 10 20/22 34
Flammable. Harmful by inhalation and if swallowed. Causes burns.
S-PHRASES: 26 36/37/39 45
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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