SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAR/2005
Date Updated: 14/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CHLOROACETIC ACID, 99%
Product Number C19627
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CHLOROACETIC ACID 79-11-8 201-178-4 607-003-00-1
Formula C2H3ClO2
Molecular Weight 94.5 AMU
Synonyms Acide chloracetique (French) * Acide
monochloracetique (French) *
Acidomonocloroacetico (Italian) * Chloracetic
acid * Chloroacetic acid * alpha-Chloroacetic
acid * Chloroethanoic acid * Kyselina
chloroctova (Czech) * MCA * Monochloorazijnzuur
(Dutch) * Monochloracetic acid *
Monochloressigsaeure (German) * Monochloroacetic
acid * Monochloroethanoic acid * NCI-C60231
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed. Causes burns. Very toxic to aquatic organisms.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 2 MG/M3
Poland NDSCh 4 MG/M3
Poland NDSP -
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 4 mg/m3
1 ppm
Remarks: =1=
Remarks: H,ARW
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level4 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 1.2 mg/m3
0.3 ppm
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
ALDRICH - C19627 www.sigma-aldrich.com Page 2
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH <1 20 掳C Concentration: 800
g/l
BP/BP Range 189 掳C 760 mmHg
MP/MP Range 60 掳C
Flash Point 126 掳C Method: closed cup
Flammability N/A
Autoignition Temp > 500 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 8 %
Vapor Pressure 0.75 mmHg 20 掳C
SG/Density N/A
Partition Coefficient Log Kow: 0.2
Viscosity 1.29 Pas 100 掳C
Vapor Density 3.26 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 750 - 850 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 1.29 mN/m 100 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents, Strong bases, Strong
reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
11 - Toxicological Information
RTECS NUMBER: AF8575000
ACUTE TOXICITY
LD50
Oral
Rat
55 mg/kg
LC50
Inhalation
Rat
180 mg/m3
LD50
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Intraperitoneal
Rat
16600 UG/KG
LD50
Subcutaneous
Rat
5 MG/KG
LD50
Subcutaneous
Mouse
250 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Multiple Routes: May be fatal if inhaled, swallowed, or absorbed
through skin.
TARGET ORGAN INFORMATION
Central nervous system. Heart. Skeletal muscle. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Mouse
Route of Application: Subcutaneous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Liver:Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 65W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
CHRONIC EXPOSURE - MUTAGEN
Mouse
548 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
400 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
160 MG/L
Cell Type: ovary
Sister chromatid exchange
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12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 48 h
Value: 28 - 70 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 71 - 85 mg/l
Test Type: LC50 Fish
Species: Poecilia reticulata
Time: 96 h
Value: 369 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1751
Class: 6.1
PG: II
Proper Shipping Name: Chloroacetic acid, solid
IMDG
UN#: 1751
Class: 6.1
PG: II
Subrisk: 8
Proper Shipping Name: Chloroacetic acid, solid
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1751
Class: 6.1
PG: II
Subrisk: 8
Proper Shipping Name: Chloroacetic acid, solid
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-003-00-1
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 25 34 50
Toxic if swallowed. Causes burns. Very toxic to aquatic
organisms.
S-PHRASES: 23 37 45 61
Do not breathe vapor. Wear suitable gloves. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible). Avoid release to the environment.
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Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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