SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAR/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CHLOROACETONITRILE, 99%
Product Number C19651
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CHLOROACETONITRILE 107-14-2 203-467-0 608-008-00-1
Formula C2H2ClN
Molecular Weight 75.5 AMU
Synonyms Chloracetonitrile * alpha-Chloroacetonitrile *
2-Chloroacetonitrile * Chloromethyl cyanide *
Monochloroacetonitrile * Monochloromethyl
cyanide * USAF KF-5
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed. Toxic
to aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Color: Yellow
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 123 - 125 掳C
MP/MP Range N/A
Flash Point 54 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 15 mmHg 30 掳C
SG/Density 1.196 g/cm3
Partition Coefficient Log Kow: 0.45
Viscosity N/A
Vapor Density 3 g/l
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Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Other Solvents: HYDROCARBONS, ALCOHOLS
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong acids, Strong bases, Strong oxidizing
agents, Strong reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Thermal decomposition may
produce carbon monoxide, carbon dioxide, and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AL8225000
ACUTE TOXICITY
LD50
Oral
Rat
220 mg/kg
LD50
Oral
Mouse
139 mg/kg
LD50
Intraperitoneal
Mouse
100 MG/KG
LD50
Skin
Rabbit
71 UL/KG
IRRITATION DATA
Skin
Rabbit
14 mg
24H
Remarks: Open irritation test
Skin
Rabbit
500 mg
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24H
Remarks: Mild irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. May cause cyanosis (blue-gray coloring of skin and
lips caused by lack of oxygen). To the best of our knowledge,
the chemical, physical, and toxicological properties have not
been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Mouse
Route of Application: Skin
Exposure Time: 2W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
15 UMOL/L
Cell Type: lymphocyte
DNA damage
Rat
115 MG/KG
Oral
Unscheduled DNA synthesis
Hamster
79100 NMOL/L
Cell Type: ovary
Sister chromatid exchange
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 1.15 - 1.580 mg/l
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2668
Class: 6.1
PG: II
Proper Shipping Name: Chloroacetonitrile
IMDG
UN#: 2668
Class: 6.1
PG: II
Subrisk: 3
Proper Shipping Name: Chloroacetonitrile
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2668
Class: 6.1
PG: II
Subrisk: 3
Proper Shipping Name: Chloroacetonitrile
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 608-008-00-1
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 23/24/25 51/53
Toxic by inhalation, in contact with skin and if swallowed.
Toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment.
S-PHRASES: 45 61
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
ALDRICH - C19651 www.sigma-aldrich.com Page 5
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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