SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/APR/2005
Date Updated: 14/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CHLOROQUINE DIPHOSPHATE CRYSTALLINE
Product Number C6628
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CHLOROQUINE DIPHOSPHATE 50-63-5 200-055-2 None
CRYSTALLINE
Formula C18H26ClN3.2H3O4P
Molecular Weight 515.87 AMU
Synonyms Alermine * Aralen diphosphate * Aralen phosphate
* Arechin * Avloclor * Bemaphate * Chingamin *
Chingamin phosphate *
7-Chlor-4-(4-(diaethylamino)-1-methylbutylamino)-
chinolindiphosphat (German) *
7-Chloro-4-((4'-diethylamino-1-methylbutyl)amino)
quinoline diphosphate * Chloroquin diphosphate *
Chloroquine diphosphate * Chloroquine phosphate
* Delagil * Gontochin phosphate * H-Stadur *
Khingamin * Klorokinfosfat * Resochin *
Resoquine * 3377 RP * Sanoquin * SN 7,618 *
Tanakan * Tanakan (antimalarial) * WR 1522
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
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9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Faintly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 213 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content <3%
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:50 mg/ml H2O Clear
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Phosphorous oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: VB2450000
ACUTE TOXICITY
LDLO
Oral
Child
250 mg/kg
Remarks: Behavioral:Coma.
LDLO
Oral
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Man
179 mg/kg
LD50
Oral
Rat
623 mg/kg
LD50
Oral
Mouse
500 mg/kg
LD50
Intraperitoneal
Mouse
68 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Subcutaneous
Mouse
200 MG/KG
LD50
Intravenous
Bird
64500 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, headache, and vomiting. Hypotension
prolonged exposure can lead to permanent corneal and retinal
changes. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Eyes. Heart.
CHRONIC EXPOSURE - MUTAGEN
Rat
100 UG/L
Cell Type: liver
Sister chromatid exchange
Hamster
100 UG/L
Cell Type: lung
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
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Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (5-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 550 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Eye, ear.
Species: Rat
Dose: 750 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 80 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (20-21D PREG)
Result: Specific Developmental Abnormalities: Respiratory
system. Effects on Newborn: Physical.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 475 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-14D PREG)
Result: Effects on Newborn: Physical.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
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R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 22 24/25
Do not breathe dust. Avoid contact with skin and eyes.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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