SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 13/APR/2005
Date Updated: 21/MAY/2004
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CHLOROBENZENE, ANHYDROUS, 99.8%
Product Number 284513
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CHLOROBENZENE 108-90-7 203-628-5 602-033-00-1
Formula C6H5Cl
Molecular Weight 112.56 AMU
Synonyms Benzene chloride * Chloorbenzeen (Dutch) *
Chlorbenzene * Chlorbenzol * Chlorobenzen
(Polish) * Chlorobenzene (ACGIH:OSHA) *
Chlorobenzenu (Czech) * Clorobenzene (Italian) *
MCB * Monochloorbenzeen (Dutch) *
Monochlorbenzene * Monochlorbenzol (German) *
Monochlorobenzene (OSHA) * Monoclorobenzene
(Italian) * NCI-C54886 * Phenyl chloride *
Tetrosin SP
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation. Toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
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EXPOSURE LIMITS
Country Source Type Value
Poland NDS 47
Poland NDSCh 94
Poland NDSP -
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 47 mg/m3
10 ppm
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 46 mg/m3
10 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 46 mg/m3
10 ppm
Remarks: 4
Remarks: Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 46 mg/m3
10 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 46 mg/m3
10 ppm
Remarks: C M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 234 mg/m3
50 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 132 掳C 760 mmHg
MP/MP Range -46 - -45 掳C
Flash Point 27 掳C Method: closed cup
Flammability N/A
Autoignition Temp 637 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.3 %
Upper: 7.1 %
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Vapor Pressure 11.8 mmHg 25 掳C
SG/Density 1.107 g/cm3
Partition Coefficient Log Kow: 2.89
Viscosity N/A
Vapor Density 3.86 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 33 mN/m 25 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Other Solvents: ETHANOL, ETHYL ETHER,
BENZENE CHLOROFORM
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CZ0175000
ACUTE TOXICITY
LD50
Oral
Rat
1110 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Tremor. Behavioral:Ataxia.
LC50
Inhalation
Rat
2,965 ppm
LD50
Intraperitoneal
Rat
1655 MG/KG
LD50
Oral
Mouse
2300 mg/kg
LD50
Intraperitoneal
Mouse
515 MG/KG
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LD50
Oral
Rabbit
2250 mg/kg
LD50
Oral
Guinea pig
2250 mg/kg
LD50
Oral
Mammal
2300 mg/kg
LC50
Inhalation
Mammal
10,000 mg/m3
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Incoordination. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Harmful if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Central nervous system. Thymus. Spleen. Bone
marrow. Lungs. Testes.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Blood:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Mouse
225 MG/KG
Intraperitoneal
24H
Micronucleus test
Mouse
70 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
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Mouse
1 GM/KG
Intraperitoneal
Cytogenetic analysis
Mouse
100 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
300 MG/L
Cell Type: ovary
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 75 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 210 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Hepatobiliary
system.
Species: Rabbit
Dose: 10 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-18D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rabbit
Dose: 590 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Time: 48 h
Value: 235 mg/l
Test Type: EC50 Algae
Species: Selenastrum capricornutum resp.
Time: 96 h
Value: 12.5 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
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Time: 24 h
Value: 4.3 - 16 mg/l
Test Type: EC50 Daphnia
Time: 24 h
Value: 7.6 mg/l
Test Type: LC100 Fish
Species: Leuciscus idus
Time: 48 h
Value: 0.03 - 28 mg/l
Test Type: LC50 Fish
Species: Cyprinodon variegatus (Sheepshead minnow)
Time: 96 h
Value: 10 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 76 h
Value: 4.5 - 7.40 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1134
Class: 3
PG: III
Proper Shipping Name: Chlorobenzene
IMDG
UN#: 1134
Class: 3
PG: III
Proper Shipping Name: Chlorobenzene
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1134
Class: 3
PG: III
Proper Shipping Name: Chlorobenzene
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-033-00-1
INDICATION OF DANGER: Xn N
Harmful. Dangerous for the environment.
R-PHRASES: 10 20 51/53
Flammable. Harmful by inhalation. Toxic to aquatic organisms,
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may cause long-term adverse effects in the aquatic environment.
S-PHRASES: 24/25 61
Avoid contact with skin and eyes. Avoid release to the
environment. Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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