SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/APR/2005
Date Updated: 06/JAN/2005
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CHLOROMETHYL METHYL ETHER, TECH.
Product Number 100331
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CHLOROMETHYL METHYL ETHER 107-30-2 203-480-1 603-075-00-3
Formula C2H5ClO
Molecular Weight 80.51 AMU
Synonyms Chlordimethylether (Czech) * Chloromethyl methyl
ether (ACGIH:OSHA) * CMME * Dimethylchloroether
* Ether, dimethyl chloro * Ether methylique
monochlore (French) * Methylchloromethyl ether *
Monochlorodimethyl ether * RCRA waste number U046
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Highly flammable. Also harmful by inhalation, in
contact with skin and if swallowed.
Carc. Cat.1
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid contact with eyes, skin, and
clothing. Avoid prolonged or repeated exposure. Do not breathe
vapor.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Readily hydrolyzed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
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Property Value At Temperature or Pressure
pH N/A
BP/BP Range 55 - 57 掳C
MP/MP Range N/A
Flash Point 16 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 183.535 mmHg 20 掳C
SG/Density 1.06 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to moist air
or water.
Materials to Avoid: Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: KN6650000
ACUTE TOXICITY
LD50
Oral
Rat
367.8 mg/kg
LC50
Inhalation
Rat
55 ppm
7H
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Blood: Hemorrhage.
LC50
Inhalation
Mouse
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1,030 mg/m3
2H
LC50
Inhalation
Hamster
65 ppm
7H
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Blood: Hemorrhage.
IRRITATION DATA
Eyes
Remarks: Moderate irritation effect
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Lungs. Eyes. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
Rat
Route of Application: Inhalation
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Endocrine:Tumors.
Mouse
Route of Application: Inhalation
Exposure Time: 82D
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 26W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Tumors at site or application.
Hamster
Route of Application: Inhalation
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Mouse
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Route of Application: Subcutaneous
Exposure Time: 71W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Subcutaneous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
IARC CARCINOGEN LIST
Rating: Group 1
CHRONIC EXPOSURE - MUTAGEN
Human
5 ML/L
Cell Type: lymphocyte
DNA inhibition
Hamster
10 MG/L
Cell Type: Embryo
Morphological transformation.
SWEDISH OE CARCINOGEN: Substances which according to 21搂, AFS
2000:3, no use allowed.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1239
Class: 6.1
PG: I
Proper Shipping Name: Methyl chloromethyl ether
IMDG
UN#: 1239
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Methyl chloromethyl ether
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1239
Class: 6.1
PG: I
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Subrisk: 3
Proper Shipping Name: Methyl chloromethyl ether
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-075-00-3
NOTA: E
INDICATION OF DANGER: F T
Highly Flammable. Toxic.
R-PHRASES: 45 11 20/21/22
May cause cancer. Highly flammable. Also harmful by inhalation,
in contact with skin and if swallowed.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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