SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAR/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CHLORAL HYDRATE DEA SCHEDULE IV ITEM
Product Number C8383
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CHLORAL HYDRATE 302-17-0 206-117-5 605-014-00-6
Formula C2H3Cl3O2
Molecular Weight 165.4 AMU
Synonyms Aquachloral * Bi 3411 * Chloraldurat * Dormal *
1,1-Ethanediol, 2,2,2-trichloro- (9CI) *
Felsules * Hydral * Hydrate de chloral *
Kessodrate * Lorinal * Noctec * Nycoton * Nycton
* Phaldrone * Rectules * SK-Chloral hydrate *
Somni SED * Somnos * Sontec * Tosyl * Trawotox *
Trichloracetaldehyd-hydrat (German) *
Trichloroacetaldehyde hydrate *
Trichloroacetaldehyde monohydrate *
1,1,1-Trichloro-2,2-dihydroxyethane *
1,1,1-Trichloro-2,2-ethanediol *
2,2,2-Trichloro-1,1-ethanediol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed. Irritating to eyes and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place. Store in the dark.
SPECIAL REQUIREMENTS: Air and light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
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9 - Physical and Chemical Properties
Appearance Physical State: Solid
Form: Crystalline
Property Value At Temperature or Pressure
pH 3.5 - 4.4 Concentration: 100 g/l
BP/BP Range 96 掳C
MP/MP Range 57 - 60 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 15 mmHg 25 掳C
SG/Density 1.424 g/cm3
Partition Coefficient Log Kow: 0.99
Viscosity N/A
Vapor Density 5.1 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: VERYSOLUBLE IN BENZENE
ETHYL ETHER, AND ETHANOL FREE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Air. Light.
Materials to Avoid: alkalis, alkaline earths, alkali carbonates,
soluble barbiturates, borax, tannin, iodides, oxidizing agents,
permanganates, and alcohol.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: FM8750000
ACUTE TOXICITY
LDLO
Oral
Human
4 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
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Taste):Eye:Miosis (pupilliary constriction).
Gastrointestinal:Nausea or vomiting.
LD50
Oral
Rat
479 mg/kg
LD50
Skin
Rat
3030 mg/kg
LD50
Intraperitoneal
Rat
472 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Other changes.
LD50
Parenteral
Rat
710 MG/KG
LD50
Rectal
Rat
710 MG/KG
LD50
Oral
Mouse
1100 mg/kg
LD50
Intraperitoneal
Mouse
580 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
LD50
Intravenous
Mouse
530 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause headache, drowsiness, confusion,
amnesia, and cardiac arrhythmias. Gastrointestinal disturbances.
CNS depression. Exposure to and/or consumption of alcohol may
increase toxic effects. Prolonged or repeated exposure can lead
to habituation or addiction. Symptoms may be delayed.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
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TARGET ORGAN INFORMATION
Nerves. Liver. Kidneys. Heart.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Oral
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Skin
Exposure Time: 1W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
500 UMOL/L
Cell Type: lymphocyte
Micronucleus test
Human
100 MG/L
Cell Type: lymphocyte
Other mutation test systems
Human
54 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
Human
50 MG/L
Cell Type: lymphocyte
SLN
Mouse
41 MG/KG
Intraperitoneal
Micronucleus test
Mouse
1250 MG/L
Cell Type: lymphocyte
Cytogenetic analysis
Mouse
82700 UG/KG
Intraperitoneal
SLN
Mouse
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1 GM/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
500 MG/KG
Cell Type: S. cerevisiac
Host-mediated assay
Hamster
80 MG/L
Cell Type: lung
Micronucleus test
Hamster
1 MG/L
Cell Type: Embryo
Morphological transformation.
Hamster
165 MG/L
Cell Type: Embryo
Other mutation test systems
Hamster
100 MG/L
Cell Type: Embryo
SLN
Hamster
500 MG/L
Cell Type: lung
SLN
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 13 GM/KG
Route of Application: Oral
Exposure Time: (3W PRE-3W POST)
Result: Effects on Newborn: Behavioral.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 500 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 1,720 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact the Drug Enforcement Administration concerning the
disposal of controlled substances. Observe all federal, state, and
local environmental regulations.
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14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 605-014-00-6
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25 36/38
Toxic if swallowed. Irritating to eyes and skin.
S-PHRASES: 23 45
Do not breathe fumes. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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