SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/OCT/2004
Date Updated: 14/MAR/2004
Version 1.10
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACRYLIC ACID, 99%
Product Number 147230
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACRYLIC ACID ANHYDROUS 79-10-7 201-177-9 607-061-00-8
Formula C3H4O2
Molecular Weight 72.06 AMU
Synonyms Acroleic acid * Acrylic acid (ACGIH) * Acrylic
acid, glacial * Ethylenecarboxylic acid *
Glacial acrylic acid * Kyselina akrylova (Czech)
* Propene acid * Propenoic acid * 2-Propenoic
acid (9CI) * RCRA waste number U008 *
Vinylformic acid
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation, in contact with skin and if
swallowed. Causes severe burns. Very toxic to aquatic organisms.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 20 MG/M3
Poland NDSCh 50 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
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Source Type Value
OEL TWA 5.9 mg/m3
2 ppm
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 30 mg/m3
10 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 30 mg/m3
10 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 30 mg/m3
10 ppm
OEL STEL 60 mg/m3
20 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Odor: Stench.
Property Value At Temperature or Pressure
pH 1-2 Concentration: 500 g/l
BP/BP Range 139 掳C 760 mmHg
MP/MP Range 12 掳C
Flash Point 46 掳C Method: closed cup
Flammability N/A
Autoignition Temp 396 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2 %
Upper: 13.7 %
Vapor Pressure 4 mmHg 20 掳C
SG/Density 1.05 g/cm3
Partition Coefficient Log Kow: 0.46
Viscosity 1.3 Pas 20 掳C
Vapor Density 2.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.2 %
Surface Tension 28.1 mN/m 30 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
Other Solvents: MISCIBLE IN ALCOHOL, ETHER
CHLOROFORM SOLUBLE IN BE
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10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
STABILIZERS PRESENT
inhibited with 20 ppm hydroquinone monomethyl ether (MEHQ).
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will occur
11 - Toxicological Information
RTECS NUMBER: AS4375000
ACUTE TOXICITY
LD50
Oral
Rat
2,590 mg/kg
LD50
Oral
Rat
1,500 mg/kg
LD50
Oral
Rat
193 mg/kg
LD50
Oral
Rat
2,600 mg/kg
LD50
Oral
Rat
360 mg/kg
LD50
Oral
Mouse
2,400 mg/kg
LD50
Oral
Mouse
830 mg/kg
LD50
Oral
Mouse
1,200 mg/kg
LC50
Inhalation
Rat
1,202 - 3,840 ppm
4H
LC50
Inhalation
Rat
> 5,100 mg/m3
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4H
LC50
Inhalation
Rat
3,600 mg/m3
4H
LC50
Inhalation
Rat
25,800 mg/m3
30 MIN
LD50
Skin
Rabbit
280 mg/kg
LD50
Skin
Rabbit
640 mg/kg
LD50
Skin
Rabbit
990 mg/kg
LD50
Skin
Rabbit
295 mg/kg
LD50
Skin
Rabbit
750 mg/kg
LD50
Oral
Rat
33.5 mg/kg
LD50
Intraperitoneal
Rat
22 MG/KG
LD50
Oral
Mouse
2400 mg/kg
Remarks: Tumorigenic:Active as anti-cancer agent.
LC50
Inhalation
Mouse
5,300 mg/m3
2H
LD50
Intraperitoneal
Mouse
144 MG/KG
LD50
Subcutaneous
Mouse
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1590 MG/KG
LD50
Skin
Rabbit
280 UL/KG
IRRITATION DATA
Skin
Rabbit
500 mg
Remarks: Open irritation test
Skin
Rabbit
5 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
1 mg
Remarks: Severe irritation effect
Eyes
Rabbit
0.25 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes severe burns.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes severe burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Skin
Exposure Time: 78W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Leukemia
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Mouse
Route of Application: Subcutaneous
Exposure Time: 52W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Skin
Exposure Time: 78W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Mouse
450 MG/L
Cell Type: lymphocyte
Cytogenetic analysis
Mouse
500 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
116 MG/L
Cell Type: ovary
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 14340 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (5-15D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 7329 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (5-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 169 GM/KG
Route of Application: Oral
Exposure Time: (13W MALE/13W PRE-3W POST)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain). Effects on Newborn: Physical.
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Species: Rat
Dose: 43680 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Maternal Effects: Other effects. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 96 h
Value: 0.04 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 95 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 27 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 315 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2218
Class: 8
PG: II
Proper Shipping Name: Acrylic acid, inhibited
IMDG
UN#: 2218
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Acrylic acid, inhibited
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2218
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Acrylic acid, stabilized
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Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-061-00-8
NOTA: D
INDICATION OF DANGER: C N
Corrosive. Dangerous for the environment.
R-PHRASES: 10 20/21/22 35 50
Flammable. Harmful by inhalation, in contact with skin and if
swallowed. Causes severe burns. Very toxic to aquatic organisms.
S-PHRASES: 26 36/37/39 45 61
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible). Avoid release to the environment.
Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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