SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 18/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETONE, ALDRASORB
Product Number 539481
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETONE, WITH MOLECULAR SIEVE 67-64-1 200-662-2 606-001-00-8
Formula C3H6O
Molecular Weight 58.08 AMU
Synonyms Aceton (German, Dutch, Polish) * Acetone
(ACGIH:OSHA) * Chevron acetone *
Dimethylformaldehyde * Dimethylketal * Dimethyl
ketone * Ketone, dimethyl * Ketone propane *
beta-Ketopropane * Methyl ketone * Propanone *
2-Propanone * Pyroacetic acid * Pyroacetic ether
* RCRA waste number U002
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Irritating to eyes. Repeated exposure may cause
skin dryness or cracking. Vapors may cause drowsiness and
dizziness.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame. Store in a cool dry place. This
product contains a molecular trap to maintain low moisture
levels in the solvent.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
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reuse.
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 1,210 mg/m3
500 ppm
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 600 mg/m3
250 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 1,200 mg/m3
500 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 295 mg/m3
125 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level600 mg/m3
250 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 1,200 mg/m3
500 ppm
Remarks: M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 1,810 mg/m3
750 ppm
OEL STEL 3,620 mg/m3
1,500 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 56 掳C 760 mmHg
MP/MP Range -94 掳C
Flash Point -17 掳C Method: closed cup
Flammability N/A
Autoignition Temp 465 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2 %
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Upper: 13 %
Vapor Pressure 184 mmHg 20 掳C
SG/Density 0.79 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 2 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Bases, Oxidizing agents, Reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AL3150000
ACUTE TOXICITY
LD50
Oral
Rat
5800 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Tremor.
LC50
Inhalation
Rat
50,100 mg/m3
8H
LD50
Intravenous
Rat
5500 MG/KG
LD50
Oral
Mouse
3000 mg/kg
LC50
Inhalation
Mouse
44,000 mg/m3
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4H
LD50
Intraperitoneal
Mouse
1297 MG/KG
LD50
Oral
Rabbit
5340 mg/kg
LD50
Skin
Guinea pig
>9400 UL/KG
IRRITATION DATA
Eyes
Human
500 ppm
Skin
Rabbit
395 mg
Remarks: Open irritation test
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
20 mg
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
SENSITIZATION
Sensitization: Causes dermatitis.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys.
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CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
CHRONIC EXPOSURE - MUTAGEN
Hamster
40 GM/L
Cell Type: fibroblast
Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 273 GM/KG
Route of Application: Oral
Exposure Time: (13W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mammal
Dose: 31500 UG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1090
Class: 3
PG: II
Proper Shipping Name: Acetone
IMDG
UN#: 1090
Class: 3
PG: II
Proper Shipping Name: Acetone
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1090
Class: 3
PG: II
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Proper Shipping Name: Acetone
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 606-001-00-8
NOTA: 6
INDICATION OF DANGER: F Xi
Highly Flammable. Irritant.
R-PHRASES: 11 36 66 67
Highly flammable. Irritating to eyes. Repeated exposure may
cause skin dryness or cracking. Vapors may cause drowsiness and
dizziness.
S-PHRASES: 9 16 26
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. In case of contact with eyes,
rinse immediately with plenty of water and seek medical advice.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 5
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 3749
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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