Material Safety Data Sheet
Date Printed: 18/AUG/2005
Date Updated: 30/JUL/2004
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
1 - Product and Company Information
Product Name ACETONITRILE-D3, "100" (>= 99.96 ATOM %
D) (CONTAINS 0.03% V/V TMS)
Product Number 425796
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
ACETONITRILE DEUTERATED 2206-26-0 218-616-5 608-001-00-3
Molecular Weight 44.08 AMU
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation, in contact with skin and
if swallowed. Irritating to eyes.
4 - First Aid Measures
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
Suitable: Carbon dioxide, dry chemical powder, or appropriate
Unsuitable: Carbon Dioxide, dry chemical powder, or appropriate
foam. Water can be applied as a spray or fog and if properly
applied is capable of extinguishing the fire by sweeping the
flames off the surface of the burning liquid.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
7 - Handling and Storage
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame. Store in a cool dry place. Handle
and store under nitrogen.
SPECIAL REQUIREMENTS: Handle and store under inert gas.
8 - Exposure Controls / Personal Protection
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
BP/BP Range 80.7 掳C 760 mmHg
MP/MP Range N/A
Flash Point 6 掳C Method: closed cup
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.84 g/cm3
Partition Coefficient N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Miscellaneous Data N/A
10 - Stability and Reactivity
Conditions to Avoid: Moisture.
Materials to Avoid: Acids, Bases, Oxidizing agents, Reducing
agents, Alkali metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen cyanide.
Hazardous Polymerization: Will not occur
11 - Toxicological Information
SIGNS AND SYMPTOMS OF EXPOSURE
This material can produce a cyanide like effect. Always have a
cyanide first-aid kit present when using this material. The
onset of symptoms is generally delayed pending conversion to
cyanide. Adverse effects may include nausea, vomiting, diarrhea,
headache, dizziness, rashes and cyanosis. Other symptoms include
mental excitement or depression, drowsiness, impaired
perception, incoordination, stupor, coma, and death.
ROUTE OF EXPOSURE
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Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Liver. Kidneys. Blood. Lungs.
CONDITIONS AGGRAVATED BY EXPOSURE
Acetonitrile is metabolized in the liver to water, formic acid,
and hydrogen cyanide. The cyanide is further metabolized to
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
12 - Ecological Information
No data available.
13 - Disposal Considerations
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
Proper Shipping Name: Acetonitrile
Proper Shipping Name: Acetonitrile
Marine Pollutant: No
Severe Marine Pollutant: No
Proper Shipping Name: Acetonitrile
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 608-001-00-3
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
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R-PHRASES: 11 20/21/22 36
Highly flammable. Harmful by inhalation, in contact with skin
and if swallowed. Irritating to eyes.
S-PHRASES: 16 36/37
Keep away from sources of ignition - no smoking. Wear suitable
protective clothing and gloves.
SWISS POISON CLASS: 2
16 - Other Information
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
For R&D use only. Not for drug, household or other uses.
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