SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 12/MAR/2004
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACROLEIN, 90%
Product Number 110221
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACROLEIN 107-02-8 203-453-4 605-008-00-3
Formula C3H4O
Molecular Weight 56.06 AMU
Synonyms Acraldehyde * Acraldehydeacroleina (Italian) *
Acroleina (Italian) * Acrolein (ACGIH:OSHA) *
Acroleine (Dutch, French) * Acrylaldehyd
(German) * Acrylaldehyde * Acrylic aldehyde *
Akrolein (Czech) * Akroleina (Polish) * Aldehyde
acrylique (French) * Aldeide acrilica (Italian)
* Allyl aldehyde * Aqualin * Aqualine * Crolean
* Ethylene aldehyde * Magnacide B * Magnacide H
* NSC 8819 * 2-Propenal * Prop-2-en-1-al * RCRA
waste number P003 * Slimicide
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Toxic in contact with skin and if swallowed.
Very toxic by inhalation. Causes burns. Very toxic to aquatic
organisms.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Store under inert gas. May develop
pressure. Open carefully. Light sensitive. Heat- and
air-sensitive.
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8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 0.2 MG/M3
Poland NDSCh 0.5 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.12 mg/m3
0.05 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.25 mg/m3
0.1 ppm
Remarks: =1=
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 0.25 mg/m3
0.1 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level0.2 mg/m3
0.1 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.25 mg/m3
0.1 ppm
Remarks: D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 0.23 mg/m3
0.1 ppm
OEL STEL 0.7 mg/m3
0.3 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 6
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BP/BP Range 53 掳C
MP/MP Range -87 掳C
Flash Point -29 掳C Method: closed cup
Flammability N/A
Autoignition Temp 220 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.8 %
Upper: 31 %
Vapor Pressure 209.385 mmHg 20 掳C
SG/Density 0.839 g/cm3
Partition Coefficient N/A
Viscosity 0.35 Pas 20 掳C
Vapor Density 1.94 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 24 mN/m 20 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: SOLUBLE IN PETROLEUM ETHER
IN ALCOHOL, OXYGENATED SOL
10 - Stability and Reactivity
STABILITY
Stable: Unstable.
Conditions to Avoid: May polymerize on exposure to light.
Sensitive to heat. Sensitive to air.
Materials to Avoid: Oxidizing agents, Oxygen, Bases, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur
11 - Toxicological Information
RTECS NUMBER: AS1050000
ACUTE TOXICITY
LCLO
Inhalation
Human
5500 PPB
LCLO
Inhalation
Human
153 ppm
10M
LD50
Oral
Rat
26 mg/kg
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LC50
Inhalation
Rat
18 mg/m3
4H
LD50
Intraperitoneal
Rat
4 MG/KG
LD50
Subcutaneous
Rat
50 MG/KG
Remarks: Behavioral:General anesthetic. Liver:Fatty liver
degeneration.
LD50
Oral
Mouse
13.9 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Skin and Appendages: Other: Hair. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
LC50
Inhalation
Mouse
66 ppm
6H
LD50
Intraperitoneal
Mouse
9008 UG/KG
LD50
Subcutaneous
Mouse
30 MG/KG
Remarks: Behavioral:General anesthetic. Liver:Fatty liver
degeneration.
LD50
Oral
Rabbit
7 mg/kg
LD50
Skin
Rabbit
200 mg/kg
IRRITATION DATA
Eyes
Human
0.5 ppm
12M
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Skin
Rabbit
5 mg
Remarks: Open irritation test
Skin
Rabbit
2 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
1 mg
Remarks: Severe irritation effect
Eyes
Rabbit
0.05 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns. Lachrymator.
Inhalation: May be fatal if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Liver. Cardiovascular system. Lungs. Eyes. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
30 UMOL/L
Cell Type: Other cell types
DNA damage
Human
100 UMOL/L
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Cell Type: fibroblast
DNA
Human
5 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Human
200 NMOL/L
Cell Type: fibroblast
Mutation in mammalian somatic cells.
Rat
30 MMOL/L
Cell Type: Other cell types
DNA damage
Rat
500 UG/KG
Intraperitoneal
DNA inhibition
Rat
500 UG/KG
Intraperitoneal
Other mutation test systems
Hamster
10 UMOL/L
Cell Type: ovary
Sister chromatid exchange
Hamster
500 NMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
Mammal
58 GM/L
3H
Cell Type: lymphocyte
DNA
Mammal
80 UMOL/L
Cell Type: lymphocyte
DNA inhibition
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 840 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rabbit
Dose: 6 MG/KG
Route of Application: Intravenous
Exposure Time: (9D PREG)
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Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
ECOTOXICOLOGICAL EFFECTS
Test Type: IC50 Algae
Time: 24 h
Value: 0.76 - 1.070 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.04 - 0.1 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 0.25 - 2.5 mg/l
Test Type: LC100 Fish
Species: Leuciscus idus
Time: 48 h
Value: 0.3 - 4.20 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 0.08 - 0.120 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 0.014 - 0.08 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1092
Class: 6.1
PG: I
Proper Shipping Name: Acrolein, inhibited
IMDG
UN#: 1092
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Acrolein, inhibited
Marine Pollutant: Yes
Severe Marine Pollutant: No
IATA
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UN#: 1092
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Acrolein, stabilized
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 605-008-00-3
INDICATION OF DANGER: F T+ N
Highly Flammable. Very toxic. Dangerous for the environment.
R-PHRASES: 11 24/25 26 34 50
Highly flammable. Toxic in contact with skin and if swallowed.
Very toxic by inhalation. Causes burns. Very toxic to aquatic
organisms.
S-PHRASES: 23 26 28 36/37/39 45 61
Do not breathe vapor. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. After
contact with skin, wash immediately with plenty of soap and
water. Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 1
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 6800000
YL-group: 5
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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