SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 12/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETYLACETONE, WACKER QUALITY
Product Number 10916
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2,4-PENTANEDIONE 123-54-6 204-634-0 606-029-00-0
Formula C5H8O2
Molecular Weight 100.12 AMU
Synonyms Acetoacetone * Acetone, acetyl- * Acetylacetone
* Acetyl 2-propanone * Diacetylmethane *
Pentanedione * Pentanedione-2,4
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Vapor may travel considerable distance to
source of ignition and flash back.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath. Use
nonsparking tools.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 6 20 掳C Concentration: 200
g/l
BP/BP Range 136 - 138 掳C
MP/MP Range -23 掳C
Flash Point 38 掳C Method: closed cup
Flammability N/A
Autoignition Temp 350 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.7 %
Upper: 11.4 %
Vapor Pressure 2.96 mmHg
SG/Density 0.972 g/cm3
Partition Coefficient Log Kow: 1.9
Viscosity N/A
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 31.2 mN/m 20 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
Other Solvents: ALCOHOL, ETHER, CHLOROFORM
ACETONE MISCIBLE WITH: GLACIAL ACETIC ACID
BENZENE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Reducing agents,
Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: SA1925000
ACUTE TOXICITY
LD50
Oral
Rat
55 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Rigidity (includes catalepsy).
LD50
Oral
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Mouse
951 mg/kg
LD50
Intraperitoneal
Mouse
750 MG/KG
LD50
Skin
Rabbit
810 UL/KG
IRRITATION DATA
Skin
Rabbit
10 mg
24H
Remarks: Open irritation test
Skin
Rabbit
488 mg
Remarks: Open irritation test
Eyes
Rabbit
20 mg
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Thymus. Nerves.
CONDITIONS AGGRAVATED BY EXPOSURE
May cause nervous system disturbances.
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Rat
694 PPM
Inhalation
6H/5D
Dominant lethal test
Hamster
80 MG/L
Cell Type: ovary
Mutation in mammalian somatic cells.
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CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 398 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Time: 24 h
Value: > 300 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 40 mg/l
Test Type: EC100 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 90 mg/l
Test Type: LC50 Fish
Species: other fish
Time: 96 h
Value: 106 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 146 mg/l
Remarks: The test is normally an EC50 or IC50 over 72
hours.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2310
Class: 3
PG: III
Proper Shipping Name: Pentan-2,4-dione
IMDG
UN#: 2310
Class: 3
PG: III
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Subrisk: 6.1
Proper Shipping Name: Pentane-2,4-dione
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2310
Class: 3
PG: III
Subrisk: 6.1
Proper Shipping Name: Pentane-2,4-dione
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 606-029-00-0
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 10 22
Flammable. Harmful if swallowed.
S-PHRASES: 21 23 24/25
When using do not smoke. Do not breathe vapor. Avoid contact
with skin and eyes.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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