SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/OCT/2004
Date Updated: 13/MAR/2004
Version 1.7
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETONITRILE MIN. 99.5 % (GC)
Product Number 60005
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETONITRILE 75-05-8 200-835-2 608-001-00-3
Formula C2H3N
Molecular Weight 41.05 AMU
Synonyms Acetonitril (German, Dutch) * Acetonitrile
(ACGIH:OSHA) * Cyanomethane * Cyanure de methyl
(French) * Ethanenitrile * Ethyl nitrile *
Methanecarbonitrile * Methane, cyano- *
Methylkyanid (Czech) * NCI-C60822 * RCRA waste
number U003 * USAF EK-488
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation, in contact with skin and
if swallowed. Irritating to eyes.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame. Handle and store under nitrogen.
SPECIAL REQUIREMENTS: Handle and store under inert gas.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
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reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 70 MG/M3
Poland NDSCh 140 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 70 mg/m3
40 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 34 mg/m3
20 ppm
Remarks: 4
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 50 mg/m3
30 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level50 mg/m3
30 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 70 mg/m3
40 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 68 mg/m3
40 ppm
OEL STEL 102 mg/m3
60 ppm
Remarks: Indicative limit value
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Form: Clear liquid
Odor: Pungent
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 81 - 82 掳C
MP/MP Range -48 掳C
Flash Point 2 掳C Method: closed cup
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Flammability N/A
Autoignition Temp 523 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 4.4 %
Upper: 16 %
Vapor Pressure 72.8 mmHg 20 掳C
SG/Density 0.782 g/cm3
Partition Coefficient Log Kow: -0.34
Viscosity 0.35 Pas 20 掳C
Vapor Density 1.41 g/l
Saturated Vapor Conc. N/A
Evaporation Rate 5.79
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.05 %
Surface Tension 29.04 mN/m 20 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: MISCIBE WITH METHANOL,
ACETONE ETHYL ACETATE, ETHER C
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acids, Bases, Oxidizing agents, Reducing
agents, Alkali metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen cyanide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AL7700000
ACUTE TOXICITY
LD50
Oral
Rat
2,460 mg/kg
LD50
Oral
Mouse
591 mg/kg
LC50
Inhalation
Rat
13,740 ppm
8H
LC50
Inhalation
Mouse
3,587 ppm
4H
LD50
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Skin
Rabbit
> 2,000 mg/kg
LD50
Oral
Rat
2460 mg/kg
LC50
Inhalation
Rat
7,551 ppm
8H
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Blood: Hemorrhage.
LD50
Intraperitoneal
Rat
850 MG/KG
LD50
Subcutaneous
Rat
3500 MG/KG
LD50
Intravenous
Rat
1680 MG/KG
LD50
Parenteral
Rat
1100 MG/KG
LD50
Oral
Mouse
269 mg/kg
LC50
Inhalation
Mouse
2,693 ppm
1H
Remarks: Liver:Other changes.
LD50
Intraperitoneal
Mouse
175 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Behavioral:Ataxia. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Subcutaneous
Mouse
4480 MG/KG
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LD50
Intravenous
Mouse
612 MG/KG
LD50
Oral
Cat
200 mg/kg
LC50
Inhalation
Cat
18,000 mg/m3
LD50
Oral
Rabbit
50 mg/kg
LC50
Inhalation
Rabbit
2,828 ppm
4H
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Blood: Hemorrhage.
LD50
Skin
Rabbit
1250 UL/KG
LD50
Oral
Guinea pig
177 mg/kg
LC50
Inhalation
Guinea pig
5,655 ppm
4H
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Blood: Hemorrhage.
LD50
Oral
Mammal
1670 mg/kg
IRRITATION DATA
Skin
Rabbit
500 mg
Remarks: Mild irritation effect
Eyes
Rabbit
20 mg
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Remarks: Severe irritation effect
Skin
Rabbit
500 mg
Remarks: Open irritation test
SIGNS AND SYMPTOMS OF EXPOSURE
This material can produce a cyanide like effect. Always have a
cyanide first-aid kit present when using this material. The
onset of symptoms is generally delayed pending conversion to
cyanide. Adverse effects may include nausea, vomiting, diarrhea,
headache, dizziness, rashes and cyanosis. Other symptoms include
mental excitement or depression, drowsiness, impaired
perception, incoordination, stupor, coma, and death.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Liver. Kidneys. Blood. Lungs.
CONDITIONS AGGRAVATED BY EXPOSURE
Acetonitrile is metabolized in the liver to water, formic acid,
and hydrogen cyanide. The cyanide is further metabolized to
thiocyanate.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Hamster
5 GM/L
Cell Type: ovary
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Hamster
Dose: 300 MG/KG
Route of Application: Oral
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Hamster
Dose: 8000 PPM/1H
Route of Application: Inhalation
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Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1800 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-20D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rabbit
Dose: 390 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Maternal Effects: Other effects. Effects on Embryo or
Fetus: Fetal death. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Hamster
Dose: 400 MG/KG
Route of Application: Oral
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Hamster
Dose: 5000 PPM/1H
Route of Application: Inhalation
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Central nervous system.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 1,640 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 3,600 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 1,000 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 24 h
Value: 10,000 mg/l
Test Type: IC50 Algae
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Time: 72 h
Value: 7,300 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1648
Class: 3
PG: II
Proper Shipping Name: Acetonitrile
IMDG
UN#: 1648
Class: 3
PG: II
Proper Shipping Name: Acetonitrile
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1648
Class: 3
PG: II
Proper Shipping Name: Acetonitrile
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 608-001-00-3
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
R-PHRASES: 11 20/21/22 36
Highly flammable. Harmful by inhalation, in contact with skin
and if swallowed. Irritating to eyes.
S-PHRASES: 16 36/37
Keep away from sources of ignition - no smoking. Wear suitable
protective clothing and gloves.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 2
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 21840
YL-group: 5
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Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
Declaration Number: 1934
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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