SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 12/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETONYLACETONE, 98+%
Product Number 165131
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2,5-HEXANEDIONE, 97% (GC) 110-13-4 203-738-3 None
Formula C6H10O2
Molecular Weight 114.14 AMU
Synonyms Acetone, acetonyl- * Acetonyl acetone *
Diacetonyl * alpha,beta-Diacetylethane *
1,2-Diacetylethane * 2,5-Diketohexane
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes and skin. Harmful: danger of serious damage to
health by prolonged exposure through inhalation in contact with
skin, and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Rubber gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 68 - 70 掳C 11 mmHg
MP/MP Range -6 掳C
Flash Point 80 掳C Method: closed cup
Flammability N/A
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Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.97 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.1 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents, Strong bases, Strong
reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
11 - Toxicological Information
RTECS NUMBER: MO3150000
ACUTE TOXICITY
LD50
Oral
Rat
2076 mg/kg
LD50
Intraperitoneal
Rat
800 MG/KG
LD50
Oral
Mouse
2386 mg/kg
LD50
Intraperitoneal
Mouse
1600 MG/KG
LD50
Skin
Guinea pig
6600 UL/KG
IRRITATION DATA
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Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
Eyes
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Neurotoxic effects. Dermatitis. To the best of our knowledge,
the chemical, physical, and toxicological properties have not
been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin. Vapor or mist is irritating to the eyes, mucous
membranes, and upper respiratory tract.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 3400 MG/KG
Route of Application: Subcutaneous
Exposure Time: (12-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 4200 MG/KG
Route of Application: Oral
Exposure Time: (42D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Other effects on male.
Species: Rat
Dose: 28 GM/KG
Route of Application: Oral
Exposure Time: (28D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 28 GM/KG
Route of Application: Oral
Exposure Time: (28D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 14934 MG/KG
Route of Application: Oral
Exposure Time: (3W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 93 GM/KG
Route of Application: Oral
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Exposure Time: (6W PRE)
Result: Maternal Effects: Oogenesis.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 36/38 48/20/21/22
Irritating to eyes and skin. Harmful: danger of serious damage
to health by prolonged exposure through inhalation in contact
with skin, and if swallowed.
S-PHRASES: 23 26 36/37
Do not breathe vapor. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing and gloves.
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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