SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/FEB/2005
Date Updated: 01/JUL/2004
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 1-BUTANOL
Product Number BT105
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
1-BUTANOL 71-36-3 200-751-6 603-004-00-6
Formula C4H10O
Molecular Weight 74.12 AMU
Synonyms Alcool butylique (French) * Butanol * n-Butanol
(ACGIH) * n-Butanol * 1-Butanol * Butan-1-ol *
n-Butan-1-ol * Butanolen (Dutch) * Butanolo
(Italian) * n-Butyl alcohol * 1-Butyl alcohol *
n-Butyl alcohol (OSHA) * Butyl hydroxide *
Butylowy alkohol (Polish) * Butyric or normal
primary butyl alcohol * CCS 203 * Hemostyp *
1-Hydroxybutane * Methylolpropane *
Propylcarbinol * Propylmethanol * RCRA waste
number U031
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful if swallowed. Irritating to respiratory system
and skin. Risk of serious damage to eyes. Vapors may cause
drowsiness and dizziness.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Vapor may travel considerable distance to
source of ignition and flash back. Flammable liquid.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
SPECIAL REQUIREMENTS: Handle and store under inert gas.
Hygroscopic.
SIGMA - BT105 www.sigma-aldrich.com Page 2
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 50 MG/M3
Poland NDSCh 150 MG/M3
Poland NDSP -
USA OSHA. PEL 150 mg/m3
50 ppm
USA ACGIH TLV 152 mg/m3
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 150 mg/m3
50 ppm
Remarks: LH
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 300 mg/m3
100 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 75 mg/m3
25 ppm
Remarks: T
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level45 mg/m3
15 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 150 mg/m3
50 ppm
Remarks: H D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL STEL 154 mg/m3
50 ppm
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
SIGMA - BT105 www.sigma-aldrich.com Page 3
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 117.7 掳C 760 mmHg
MP/MP Range -90 掳C
Flash Point 35 掳C Method: closed cup
Flammability N/A
Autoignition Temp 343 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.4 %
Upper: 11.2 %
Vapor Pressure 4 mmHg 20 掳C
SG/Density 0.811 g/cm3
Partition Coefficient N/A
Viscosity 3 Pas 20 掳C
Vapor Density 2.55 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Oxidizing agents, Alkali metals, Bases, Strong
acids, Halogens.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: EO1400000
ACUTE TOXICITY
LD50
Oral
Rat
2,500 mg/kg
LD50
Oral
Rabbit
3,400 mg/kg
LC50
Inhalation
Rat
SIGMA - BT105 www.sigma-aldrich.com Page 4
8,000 ppm
4 HR.
LD50
Skin
Rabbit
5,300 mg/kg
LD50
Oral
Rat
790 mg/kg
Remarks: Liver:Fatty liver degeneration. Kidney, Ureter,
Bladder:Other changes. Blood:Other changes.
LC50
Inhalation
Rat
8,000 ppm
4H
LD50
Intraperitoneal
Rat
1122 MG/KG
LD50
Intravenous
Rat
310 MG/KG
LD50
Oral
Mouse
2680 mg/kg
LD50
Intraperitoneal
Mouse
254 MG/KG
Remarks: Liver:Other changes.
LD50
Subcutaneous
Mouse
3200 MG/KG
LD50
Intravenous
Mouse
377 MG/KG
LD50
Oral
Rabbit
3484 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Cardiac:Pulse rate. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Skin
Rabbit
SIGMA - BT105 www.sigma-aldrich.com Page 5
3400 mg/kg
LC50
Inhalation
Mammal
28,400 mg/m3
LD50
Oral
Bird (wild)
2500 mg/kg
IRRITATION DATA
Skin
Rabbit
Remarks: Mild irritation effect
Eyes
Rabbit
Remarks: Moderate irritation effect
Eyes
Human
50 ppm
Skin
Rabbit
405 mg
24H
Remarks: Moderate irritation effect
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
2 mg
Remarks: Severe irritation effect
Eyes
Rabbit
2 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression. Exposure can cause: Gastrointestinal
disturbances. Drying, cracking, or irritation of the skin.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Ears. Liver. Kidneys. Blood.
SIGMA - BT105 www.sigma-aldrich.com Page 6
CHRONIC EXPOSURE - MUTAGEN
Hamster
100 MMOL/L
Cell Type: lung
SLN
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 35295 MG/KG
Route of Application: Oral
Exposure Time: (1-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Newborn: Biochemical and
metabolic.
Species: Rat
Dose: 23100 MG/KG
Route of Application: Oral
Exposure Time: (8W PRE/0-20D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 6000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 8000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 35295 MG/KG
Route of Application: Oral
Exposure Time: (1-15D PREG)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora
lutea). Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
N/A
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Carassius auratus (Goldfish)
Time: 24 h
Value: 1,855 mg/l
SIGMA - BT105 www.sigma-aldrich.com Page 7
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 1,840 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 24 h
Value: 1,855 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1120
Class: 3
PG: III
Proper Shipping Name: Butanols
IMDG
UN#: 1120
Class: 3
PG: III
Proper Shipping Name: Butanols
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1120
Class: 3
PG: III
Proper Shipping Name: Butanols
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-004-00-6
NOTA: 6
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 10 22 37/38 41 67
Flammable. Harmful if swallowed. Irritating to respiratory
system and skin. Risk of serious damage to eyes. Vapors may
cause drowsiness and dizziness.
S-PHRASES: 7/9 13 26 37/39 46
Keep container tightly closed and in well-ventilated place.
Keep away from food, drink, and animal feedingstuffs. In case
of contact with eyes, rinse immediately with plenty of water
and seek medical advice. Wear suitable gloves and eye/face
protection. If swallowed, seek medical advice immediately and
show this container or label.
SIGMA - BT105 www.sigma-aldrich.com Page 8
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 10800
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA - BT105 www.sigma-aldrich.com Page 9
|