SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/FEB/2005
Date Updated: 19/APR/2004
Version 1.0
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name SODIUM CACODYLATE TRIHYDRATE (FW 214)
Product Number C0250
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CACODYLIC ACID, SODIUM SALT, 6131-99-3 204-708-2 033-002-00-5
TRIHYDRATE
Formula C2H6AsNaO2 路 3H2O
Molecular Weight 214 AMU
Synonyms Dimethylarsenic acid sodium salt trihydrate *
Dimethylarsinic acid sodium salt trihydrate *
Hydroxydimethylarsine oxide sodium salt
trihydrat * Sodium dimethylarsinic acid
trihydrate
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation and if swallowed. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store with desiccant.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
MSHA Standard-air TWA 0.5 mg/m3
USA OSHA. PEL TWA 0.5 mg/m3
Remarks: CONSTRUC: 8H
USA OSHA. PEL TWA 0.5 mg/m3
Remarks: FED CONT: 8H
USA OSHA. PEL TWA 0.5 mg/m3
Remarks: GEN INDU:8H
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USA OSHA. PEL TWA 0.5 mg/m3
Remarks: SHIPYARD:8H
EXPOSURE LIMITS - AUSTRALIA
Source Type Value
OEL TWA 0.05 mg/m3
Remarks: Carcinogen.
Remarks: ARSENIC
EXPOSURE LIMITS - BELGIUM
Source Type Value
OEL TWA 0.2 mg/m3
Remarks: Carcinogen.
Remarks: ARSENIC
EXPOSURE LIMITS - FINLAND
Source Type Value
Remarks: Carcinogen.
EXPOSURE LIMITS - FRANCE
Source Type Value
OEL TWA 0.2 mg/m3
VME (TWA)
Remarks: ARSENIC
EXPOSURE LIMITS - GREECE
Source Type Value
Remarks: Carcinogen.
EXPOSURE LIMITS - HUNGARY
Source Type Value
OEL TWA 0.2 mg/m3
VME (TWA)
Remarks: ARSENIC
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL TWA 0.01 mg/m3
Remarks: ARSENIC
EXPOSURE LIMITS - POLAND
Source Type Value
OEL TWA 0.3 mg/m3
Remarks: MAC (TWA)
Remarks: ARSENIC
EXPOSURE LIMITS - SWEDEN
Source Type Value
OEL TWA 0.03 mg/m3
Remarks: NGV (TWA)
Remarks: Carcinogen.
Remarks: ARSENIC
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL TWA 0.1 mg/m3
Remarks: MAK(TWA)
Remarks: Carcinogen.
Remarks: ARSENIC
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
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OEL TWA 0.1 mg/m3
Remarks: Carcinogen.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves. Handle with
gloves in hood.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH 8.7 Concentration: 50 g/l
BP/BP Range N/A
MP/MP Range 77 - 80 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.1 g/ml H2O, 20掳C
complete, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Arsenic oxides, Sodium/sodium oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CH7890000
ACUTE TOXICITY
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LD50
Skin
Rabbit
> 2,000 mg/kg
LC50
Inhalation
Rat
4,900 mg/m3
4H
LD50
Oral
Rat
2,000 mg/kg
IRRITATION DATA
Skin
Rabbit
Remarks: No irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Other symptoms of exposure can include dry mouth, metallic
taste, drowsiness, loss of appetite, tremors, convulsions,
respiratory arrest, and garlic odor to breath and perspiration.
Prolonged exposure to arsenic compounds can cause exfoliation
and pigmentation of skin, herpes, inflammation of nerves, and
nasal septum ulceration.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Kidneys. G.I. System. Heart. Brain. Skin. Bone marrow. Nerves.
Liver.
CONDITIONS AGGRAVATED BY EXPOSURE
Cacodylic acid may be partially reduced to inorganic arsenic in
the body. Exposure to arsenic compounds can cause burning and
dryness of the oral and nasal cavities, muscle spasms,
irritation of the gastrointestinal tract, nausea, vomiting and
diarrhea which can progress to shock and death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Hamster
Dose: 20 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
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Value: 53.5 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 17 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: > 100 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1688
Class: 6.1
PG: II
Proper Shipping Name: Sodium cacodylate
IMDG
UN#: 1688
Class: 6.1
PG: II
Proper Shipping Name: Sodium cacodylate
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1688
Class: 6.1
PG: II
Proper Shipping Name: Sodium cacodylate
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 033-002-00-5
NOTA: A, 1
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 23/25 50/53
Toxic by inhalation and if swallowed. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
S-PHRASES: 20/21 28 45 60 61
When using do not eat, drink, or smoke. After contact with
skin, wash immediately with plenty of water. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible). This material and its
container must be disposed of as hazardous waste. Avoid release
to the environment. Refer to special instructions/safety data
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sheets.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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