SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/FEB/2005
Date Updated: 12/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BRUCINE FREE BASE
Product Number B0253
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BRUCINE 357-57-3 206-614-7 614-006-00-1
Formula C23H26N2O4
Molecular Weight 394.47 AMU
Synonyms Brucina (Italian) * (-)-Brucine * Brucine
alkaloid * 2,3-Dimethoxystrychnidin-10-one *
Dimethoxy strychnine * 2,3-Dimethoxy-strychnine
* 10,11-Dimethystrychnine * RCRA waste number
P018 * Strychnidin-10-one, 2,3-dimethoxy- (9CI)
* Strychnine, 2,3-dimethoxy-
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic by inhalation and if swallowed. Harmful to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Powder
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range N/A
MP/MP Range 175 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.5 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: EH8925000
ACUTE TOXICITY
LD50
Intraperitoneal
Rat
91 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Rigidity (includes catalepsy). Behavioral:Muscle
contraction or spasticity.
LD50
Oral
Mouse
150 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intraperitoneal
Mouse
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62 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Subcutaneous
Mouse
60 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intravenous
Mouse
12 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Convulsions.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be fatal if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Central nervous system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1570
Class: 6.1
PG: I
Proper Shipping Name: Brucine
IMDG
UN#: 1570
Class: 6.1
PG: I
Proper Shipping Name: Brucine
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1570
Class: 6.1
PG: I
Proper Shipping Name: Brucine
Inhalation Packing Group I: No
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15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 614-006-00-1
INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 26/28 52/53
Very toxic by inhalation and if swallowed. Harmful to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
S-PHRASES: 13 45 61
Keep away from food, drink, and animal feedingstuffs. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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