SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/FEB/2005
Date Updated: 12/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BUTYRONITRILE, 99+%
Product Number 538264
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BUTYRONITRILE 109-74-0 203-700-6 608-005-00-5
Formula C4H7N
Molecular Weight 69.11 AMU
Synonyms Butanenitrile * n-Butanenitrile * Butyric acid
nitrile * n-Butyronitrile * Butyrylonitrile *
1-Cyanopropane * Propyl cyanide * Propylkyanid
(Czech)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Toxic by inhalation, in contact with skin and if
swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Physical State: Clear liquid
Color: Almost colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 115 - 117 掳C 760 mmHg
MP/MP Range -112 掳C
Flash Point 18 掳C Method: closed cup
Flammability N/A
Autoignition Temp 488 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.65 %
Vapor Pressure 23 mmHg 25 掳C
SG/Density 0.79 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 2.4 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong acids, Strong bases, Strong oxidizing
agents, Strong reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Thermal decomposition may
produce carbon monoxide, carbon dioxide, and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: ET8750000
ACUTE TOXICITY
LD50
Oral
Rat
50 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Vascular:Regional or general arteriolar or venous dilation.
Lungs, Thorax, or Respiration:Dyspnea.
LD50
Intraperitoneal
Rat
50 MG/KG
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Remarks: Behavioral:Convulsions or effect on seizure threshold.
Vascular:Regional or general arteriolar or venous dilation.
Lungs, Thorax, or Respiration:Dyspnea.
LD50
Oral
Mouse
27.689 mg/kg
LC50
Inhalation
Mouse
249 ppm
1H
Remarks: Liver:Other changes.
LD50
Intraperitoneal
Mouse
38 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Behavioral:Ataxia. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Skin
Rabbit
500 UL/KG
IRRITATION DATA
Skin
Rabbit
395 mg
Remarks: Open irritation test
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
May cause cyanosis (blue-gray coloring of skin and lips caused
by lack of oxygen).
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Eyes. Central nervous system. Cardiovascular system. Skin.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 200 PPM/6H
Route of Application: Inhalation
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Exposure Time: (6-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2411
Class: 3
PG: II
Proper Shipping Name: Butyronitrile
IMDG
UN#: 2411
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Butyronitrile
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2411
Class: 3
PG: II
Subrisk: 6.1
Proper Shipping Name: Butyronitrile
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 608-005-00-5
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 10 23/24/25
Flammable. Toxic by inhalation, in contact with skin and if
swallowed.
S-PHRASES: 45
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
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purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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