SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/FEB/2005
Date Updated: 08/NOV/2004
Version 1.2
According to 91/155/EEC
1 - Product and Company Information
Product Name BUMETANIDE
Product Number B3023
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BUMETANIDE 28395-03-1 249-004-6 None
Formula C17H20N2O5S
Molecular Weight 364.4 AMU
Synonyms 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic
acid * Benzoic acid,
3-(aminosulfonyl)-5-(butylamino)-4-phenoxy- *
Bumetanide * Bumex * Burine * Burinex *
3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
* Fontego * Fordiuran * Lunetoron * PF 1593 * Ro
10-6338 * Segurex
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear protective equipment.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
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Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DG4910000
ACUTE TOXICITY
LD50
Oral
Rat
> 6000 mg/kg
LD50
Intraperitoneal
Rat
891 MG/KG
LD50
Subcutaneous
Rat
>2 GM/KG
LD50
Intravenous
Rat
>200 MG/KG
LD50
Intramuscular
Rat
>5 MG/KG
LD50
Oral
Mouse
4624 mg/kg
LD50
Intraperitoneal
Mouse
519 MG/KG
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LD50
Subcutaneous
Mouse
1660 MG/KG
LD50
Intravenous
Mouse
>200 MG/KG
LD50
Intramuscular
Mouse
>25 MG/KG
LD50
Oral
Rabbit
350 mg/kg
LD50
Intravenous
Rabbit
70 MG/KG
LD50
Intravenous
Mammal
6200 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Potent diuretic excess amounts can lead to a profound diuresis
with water and electrolyte depletion. Can cause muscle cramps,
dizziness, hypotension, headache, encephalopathy, ototoxicity To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys. Blood. Liver. Ears. Skeletal muscle.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EC.
16 - Other Information
DISCLAIMER
For R&D or manufacturing use. Not for prescription compound or
other uses.
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