SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/FEB/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BETA-BUTYROLACTONE, 98+%
Product Number 219126
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
B-BUTYROLACTONE 3068-88-0 221-330-3 None
Formula C4H6O2
Molecular Weight 86.09 AMU
Synonyms beta-Butyrolactone * beta-Butyrolakton (Czech) *
3-Hydroxybutanoic acid, beta-lactone *
Hydroxybutyric acid lactone * 3-Hydroxybutyric
acid lactone * 3-Hydroxybutyric acid,
beta-lactone * 4-Methyl-2-oxetanone
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes and skin. Limited evidence of a carcinogenic
effect.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range 71 - 73 掳C 29 mmHg
MP/MP Range -43.5 掳C
Flash Point 60 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.056 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Readily hydrolyzed.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: RQ8050000
ACUTE TOXICITY
LD50
Oral
Rat
17200 UL/KG
LD50
Skin
Rabbit
>20 ML/KG
IRRITATION DATA
Skin
Rabbit
500 mg
Remarks: Open irritation test
SIGNS AND SYMPTOMS OF EXPOSURE
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To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 61W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
Rat
Route of Application: Subcutaneous
Exposure Time: 76W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Skin
Exposure Time: 49W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic:Tumors at site or
application.
Mouse
Route of Application: Subcutaneous
Exposure Time: 30W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Skin
Exposure Time: 67W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic:Tumors at site or
application.
Mouse
Route of Application: Skin
Exposure Time: 36W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors. Tumorigenic:Tumors
at site or application.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Mouse
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3 GM/KG
Intraperitoneal
48H
Micronucleus test
Mouse
1 GM/KG
Intraperitoneal
DNA damage
Mammal
10 MMOL/L
Cell Type: lymphocyte
DNA damage
SWEDISH OE CARCINOGEN: Substances which according to 23搂, AFS
2000:3, is allowed to use only after authorization from The
Swedish Work Environment Authority.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1993
Class: 3
PG: III
Proper Shipping Name: Flammable liquid, n.o.s.
IMDG
UN#: 1993
Class: 3
PG: III
Proper Shipping Name: Flammable liquid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 1993
Class: 3
PG: III
Proper Shipping Name: Flammable liquid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 36/38 40
Irritating to eyes and skin. Limited evidence of a carcinogenic
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effect.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
SWITZERLAND
SWISS POISON CLASS: FREI
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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