SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 02/28/2007
Date Updated: 10/12/2006
Version 1.9
Section 1 - Product and Company Information
Product Name 1,1,1-TRICHLOROETHANE, ACS, STAB.
Product Number 91099
Brand FLUKA
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
1,1,1-TRICHLOROETHANE, STABILIZED 71-55-6 Yes
Ingredient Name CAS # Percent SARA 313
LOW ALKYL EPOXIDE None 0.05 No
Formula C2H3Cl3
Synonyms Aerothene TT * CF 2 * Chloroform, methyl- *
Chlorothene * Chloroethene (inhibited) *
Chlorothene NU * Chlorothene SM * Chlorothene VG
* Chlorten * Ethana NU * F 140a * HCC 140a *
ICI-CF 2 * Inhibisol * Methylchloroform * Methyl
chloroform (ACGIH:OSHA) * Methyltrichloromethane
* NCI-C04626 * RCRA waste number U226 * Solvent
111 * alpha-T * Tafclean * 1,1,1-Trichloorethaan
(Dutch) * 1,1,1-Trichloraethan (German) *
Trichloro-1,1,1-ethane (French) *
1,1,1-Trichloroethane (DOT:OSHA) *
1,1,1-Tricloroetano (Italian) *
Trichloromethylmethane
RTECS Number: KJ2975000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful. Dangerous for the environment.
Harmful by inhalation. Irritating to eyes, respiratory system and
skin. Dangerous for the ozone layer.
Target organ(s): Liver. Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
EXPLOSION LIMITS
Lower: 7.5 % Upper: 15 %
AUTOIGNITION TEMP
537 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
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Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type AXBEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 450 PPM
USA ACGIH TWA 350 PPM
USA MSHA Standard-air TWA 350 PPM (1900 MG/M3)
USA OSHA. PEL 8H TWA 350 PPM (1900 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH Ceiling co350 PPM/15M
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 600 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 133.41 AMU
pH N/A
BP/BP Range 72.0 - 75.0 癈
MP/MP Range - 35.0 癈
Freezing Point N/A
Vapor Pressure 100 mmHg 20 癈
Vapor Density 4.6 g/l
Saturated Vapor Conc. N/A
SG/Density 1.336 g/cm3
Bulk Density N/A
Odor Threshold N/A
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Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits Lower: 7.5 %
Upper: 15 %
Flammability N/A
Autoignition Temp 537 癈
Refractive Index 1.438
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Reactions to Avoid: Reacts violently with:
Materials to Avoid: Potassium, Strong oxidizing agents, Sodium,
Magnesium, Zinc, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Harmful if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system. Kidneys. Liver. Cardiovascular system.
SIGNS AND SYMPTOMS OF EXPOSURE
Damage to the kidneys. Damage to the liver. Narcotic effect.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure to and/or consumption of alcohol may increase
toxic effects. Prolonged exposure can cause:
TOXICITY DATA
Oral
Rat
9600 mg/kg
LD50
Remarks: Cardiac:Pulse rate. Nutritional and Gross
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Metabolic:Weight loss or decreased weight gain.
Inhalation
Rat
18,000 ppm
LC50
Intraperitoneal
Rat
3593 MG/KG
LD50
Oral
Mouse
6000 mg/kg
LD50
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Cardiac:Pulse rate.
Inhalation
Mouse
3,911 ppm
LC50
Remarks: Behavioral:Excitement.
Intraperitoneal
Mouse
2568 MG/KG
LD50
Subcutaneous
Mouse
16 GM/KG
LD50
Remarks: Behavioral:Sleep. Behavioral:Ataxia.
Oral
Dog
750 mg/kg
LD50
Intraperitoneal
Dog
3100 MG/KG
LD50
Remarks: Liver:Liver function tests impaired.
Inhalation
Cat
24,400 mg/m3
LC50
Oral
Rabbit
5660 mg/kg
LD50
Oral
Guinea pig
9470 mg/kg
LD50
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IRRITATION DATA
Eyes
Man
450 ppm
8H
Skin
Rabbit
5,000 mg
12D
I
Remarks: Mild irritation effect
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
Remarks: Mild irritation effect
Eyes
Rabbit
2 mg
24H
Remarks: Severe irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
NTP CARCINOGEN LIST
Rating: Inadequate studies
Species: Mouse/rat
Route: Gavage
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 43 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/21D POST)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rat
Dose: 2100 PPM/6H
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Route of Application: Inhalation
Exposure Time: (1-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Species: Rat
Dose: 99 UMOL/L
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Mouse
Dose: 31300 UG/L (+S9)
Cell Type: lymphocyte
Mutation test: Mutation in microorganisms
Species: Mouse
Dose: 20 MG/L
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 562 MG/L
Cell Type: kidney
Mutation test: Morphological transformation.
Species: Hamster
Dose: 100 UL/PLATE
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 160 MG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 7000 PPM/3H
Route of Application: Inhalation
Exposure Time: (13-19D PREG)
Result: Effects on Newborn: Behavioral. Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Maternal Effects: Other effects.
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 53 mg/l
ODC (OZONE DEPLETING CHEMICAL) - CAA602
Ozone Depletion Class: I
Ozone Depletion Group: V
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Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: 1,1,1-Trichloroethane
UN#: 2831
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Toxic Substance
PIH: Not PIH
IATA
Proper Shipping Name: 1,1,1-Trichloroethane
IATA UN Number: 2831
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn-N
Indication of Danger: Harmful. Dangerous for the environment.
R: 20-59
Risk Statements: Harmful by inhalation. Dangerous for the ozone
layer.
S: 24/25-59-61
Safety Statements: Avoid contact with skin and eyes. Refer to
manufacturer/supplier for information on recovery/recycling.
Avoid release to the environment. Refer to special
instructions/safety data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful. Dangerous for the environment.
Risk Statements: Irritating to eyes, respiratory system and
skin. Harmful by inhalation. Dangerous for the ozone layer.
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. Refer to
manufacturer/supplier for information on recovery/recycling.
Avoid release to the environment. Refer to special
instructions/safety data sheets.
US Statements: Target organ(s): Liver. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
FLUKA - 91099 www.sigma-aldrich.com Page 8
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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