850 Lincoln Centre Drive
Foster City, CA 94404 U.S.A.
T 650.570.6667 F 650.572.2743
www.appliedbiosystems.com
Dear Valued Customer:
In an effort to better serve you, Applied Biosystems is revising the look and feel of our Material Safety Data
Sheets, (MSDSs). In addition, we will now be supplying MSDSs for materials which are classified as "non-
hazardous" as defined by the Dangerous Substances and Dangerous Preparations Directives, 67/548/EEC and
88/379/EEC respectively, (EU), and the OSHA Hazard Communication Standard, 29 CFR 1910.1200 (U.S.). As
always, MSDSs will be available in multiple languages. In the coming months, we will be implementing a system
whereby you will be able to choose your preferred method for MSDS delivery. Your delivery options are as
follows:
By E mail
By FAX
Please take a few minutes to send an e-mail to: MSDS_Inquiry_CCRM@appliedbiosystems.com to let us know
your preference. Type "MSDS Delivery" in the subject line and include your preference in the body of the letter
along with your full name, Company or Institution, and your preferred E-mail address or FAX number as
applicable. Please choose only one option. Alternatively, you may print out this letter, circle your preference
from the list above, and mail it to the address below. Please include your full name, Company or Institution, and
E-mail address or FAX number as applicable on this letter.
In the meantime, you will continue to receive your document(s) along with your order if it is the first order of the
calendar year, or when the MSDS has undergone a major revision. MSDSs are also available on our website.
For AB products, please visit: http://docs.appliedbiosystems.com/msdssearch.html.
For Ambion products, please visit: http://www.ambion.com/techlib/msds
If you are a Distributor or Dealer of Applied Biosystems Products:
As the last supplier in the chain who provides hazardous substances to a place of work, you have the
responsibility to provide a Material Safety Data Sheet (MSDS) and any updated hazard information from our
company to your customers. You are required to send the MSDS to your downstream users prior to or with the
initial delivery of a hazardous substance. When an MSDS is revised, a copy of the revised MSDS should be
sent to the purchaser as soon as it is revised.
Should you have any questions, feel free to contact us via email at:
MSDS_Inquiry_CCRM@appliedbiosystems.com or call 650-638-5635 (USA)
Thank you for your continued business.
Vergine Furniss
Global Chemical Compliance and Risk Management
Applied Biosystems
850 Lincoln Centre Drive
Foster City, CA 94404
1-800-327-3002 x5635 (USA)
Revision Date: 5-Jan-07
Version 1.0
MATERIAL SAFETY DATA SHEET
1. IDENTIFICATION OF THE MATERIAL AND SUPPLIER
PRODUCT NAME: SIPORTTM NEOFXTM TRANSFECTION AGENT
PRODUCTNUMBER : AM4510
SUPPLIER: AMBION, INC
2130 WOODWARD ST.
AUSTIN, TX, 78744
USA
www.ambion.com
IN CASE OF EMERGENCY CALL
CHEMTREC 1-800-424-9300.
PRODUCT USE DESCRIPTION: FOR RESEARCH USE ONLY. NOT FOR USE IN
DIAGNOSTIC PROCEDURES
2. HAZARDS IDENTIFICATION
Emergency Overview
Warning!
Flammable Liquid and Vapor.
Harmful by inhalation and if swallowed.
May cause respiratory tract irritation.
May cause skin irritation.
May cause eye irritation.
Affects the central nervous system, liver, blood and reproductive system.
Potential health effects
Inhalation :
Harmful if inhaled.
May cause respiratory tract irritation.
Skin :
May cause skin irritation.
Eyes :
May cause eye irritation.
Ingestion :
Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea.
May cause liver damage.
Harmful if swallowed.
Physical and chemical hazards :
Flammable liquid and vapour
Vapor may cause flash fire.
Chronic exposure:
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Prolonged skin contact may defat the skin and produce dermatitis.
Affects central nervous system, kidneys, and cardiovascular system.
May affect the reproductive system.
May cause birth defects.
Routes of exposure :
Inhalation
Skin Absorption
Target Organs :
Eyes
Skin
Respiratory system
Central nervous system
Liver
3. COMPOSITION/INFORMATION ON INGREDIENTS
Hazardous components CAS-No. Weight %
ETHANOL 64-17-5 60 - 100 %
4. FIRST AID MEASURES
Eye contact Immediately flush eyes for at least 15 minutes. Get medical attention.
Inhalation Remove to fresh air immediately. Get medical attention immediately.
If not breathing, give artificial respiration.
Skin contact Rinse immediately with plenty of water and seek medical advice.
Remove and wash contaminated clothing before re-use.
Ingestion If swallowed, call a poison control centre or doctor immediately.
Never give anything by mouth to an unconscious person.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Water spray
Carbon dioxide (CO2)
Foam
Dry chemical
Hazardous decomposition
products Carbon oxides, nitrogen oxides (NOx)
Special protective Wear self contained breathing apparatus for fire fighting if
equipment for fire-fighters necessary. Use personal protective equipment.
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6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Ensure adequate ventilation.
Avoid contact with skin, eyes and clothing.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Environmental precautions
Should not be released into the environment. Prevent product from entering drains.
Methods for cleaning up
Clean contaminated floors and objects thoroughly while observing environmental
regulations. Ensure adequate ventilation.
7. HANDLING AND STORAGE
Precautions for safe handling
Use only in area provided with appropriate exhaust ventilation. Wear personal protective
equipment. Take precautionary measures against static discharges.
Storage conditions
Protect against physical damage. Isolate from incompatible substances. Store in original
container. See product label for specific storage requirements.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Exposure limit(s)
Hazardous components Regulation Type of listing Value
ETHANOL ACGIH TWA 1,000 ppm
NIOSH IDLH 3,300 ppm
3
NIOSH TWA 1,900 mg/m 1,000 ppm
3
California PEL 1,900 mg/m 1,000 ppm
3
OSHA TWA 1,900 mg/m 1,000 ppm
Eye protection Chemical resistant goggles must be worn.
Ensure that eyewash stations and safety showers are close to the
workstation location.
Hand protection Wear suitable gloves.
Please observe the instructions regarding permeability and breakthrough
time which are provided by the supplier of the gloves. Also take into
consideration the specific local conditions under which the product is
used, such as the danger of cuts, abrasion, and the contact time.
Respiratory Avoid breathing vapors, mist or gas.
protection When workers are facing concentrations above the exposure limit they
must use appropriate certified respirators.
For unknown concentrations or Immediately Dangerous to Life or Health
(IDLH), use a full-facepiece positive pressure air supplied respirator.
Skin protection Wear suitable protective clothing.
Engineering Maintain air concentrations below occupational exposure standards. Use
measures only in area provided with appropriate exhaust ventilation.
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9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state liquid
Colour This information is not available.
Odour This information is not available.
Odour Odour This information is not available.
Threshold
pH This information is not available.
Boiling point This information is not available.
Melting point This information is not available.
Vapour pressure This information is not available.
Water solubility This information is not available.
Flash point This information is not available.
Explosion limits This information is not available.
Density This information is not available.
Percent volatile This information is not available.
Volatile organic This information is not available.
compounds (VOC)
content
10. STABILITY AND REACTIVITY
Conditions to avoid Keep away from open flames, hot surfaces and sources of ignition.
Materials to avoid Strong oxidizing agents, Acids, Alkali metals, Ammonia, Peroxides
Hazardous
decomposition Carbon oxides, nitrogen oxides (NOx)
products
11. TOXICOLOGICAL INFORMATION
Hazardous components : ETHANOL
Acute oral toxicity Oral LD50 rat 7,060 mg/kg
Further information
The product itself has not been tested.
12. ECOLOGICAL INFORMATION
We have no quantitative data concerning the ecological effects of this product.
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Component: ETHANOL
Ecotoxicity effects
Toxicity to fish flow-through LC50 Oncorhynchus mykiss (rainbow trout) 96 h
12,900 mg/l
30 days old
LC50 Pimephales promelas (fathead minnow) 96 h
14.2 mg/l
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Toxicity to bacteria EC50 Photobacterium phosphoreum 5 min
35,470 mg/l
EC50 Photobacterium phosphoreum 30 min
34,634 mg/l
Toxicity to daphnia EC50 Daphnia magna (Water flea) 48 h
9,268 mg/l
EC50 Daphnia magna (Water flea) 24 h
10,800 mg/l
13. DISPOSAL CONSIDERATIONS
Environmental Should not be released into the environment. Prevent product from
precautions entering drains.
Disposal methods Dispose of in accordance with local regulations.
General advice DISPOSAL CONSIDERATIONS
The product has to be disposed of as laboratory chemical in accordance
with local regulations.
14. TRANSPORT INFORMATION
DOT
DOT: ROAD TRANSPORT
UN-Number UN 1170
Packing group II
Hazard class 3 Flammable liquids
Proper shipping name Ethyl alcohol solutions
AIR TRANSPORT
ICAO:
UN-Number UN 1170
Proper shipping name Ethanol solution
Hazard class 3 Flammable liquids
Packing group II
HazardsLabels 3
IATA:
UN-Number UN 1170
Proper shipping name Ethanol solution
Packing group II
Hazard class 3 Flammable liquids
Packing group II
Hazards Labels 3
IMDG
UN-Number UN 1170
Proper shipping name Ethanol solution (Ethyl alcohol solution)
Hazard class 3 Flammable liquids
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Packing group II
Hazards Labels 3
15. REGULATORY INFORMATION
US Regulations
40 CFR ?302.4 Designation of hazardous substances (SARA 302).
Non-hazardous substance
40 CFR ?355 Appendices A and B - The List of Extremely Hazardous Substances and
Their Threshold Planning Quantities (SARA304).
Non-hazardous substance
40 CFR ?372.65 Toxic Chemical Release Reporting (SARA 313).
Non-hazardous substance
State Regulations
U.S. - California - 8 CCR Section 5200-5220 - Specifically Regulated Carcinogens
No components found on the California Specifically Regulated Carcinogens List.
U.S. - California - 8 CCR Section 5203 Carcinogens
No components found on the California Section 5203 Carcinogens List.
U.S. - California - 8 CCR Section 5209 Carcinogens
No components found on the California Section 5209 Carcinogens List.
U.S.- New Jersey - Worker and Community Right to Know Act (N.J.S.A. 34:5A-1)
Listed Components regulated under the New Jersey Worker and Community Right-to-
Know Act.
Hazardous components
ETHANOL
U.S.- Massachusetts - General Law Chapter 111F (MGL c 111F) - Hazardous
Substances Disclosure by Employers (a.k.a. Right to Know Law)
Listed Components regulated under the Massachusetts Hazardous Substances
Disclosure by Employers Law.
Hazardous components
ETHANOL
U.S. - California - 8 CCR Section 339 - Director's List of Hazardous Substances
Found on the California Director's List of Hazardous Substances.
Hazardous components
ETHANOL
California Prop. 65
WARNING! This product contains a chemical known in the State of California to cause
cancer.
ETHANOL Cancer
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WARNING! This product contains a chemical known in the State of California to cause
birth defects or other reproductive harm.
ETHANOL Developmental toxin.
National Inventory Status - United States of America
TOXIC SUBSTANCES CONTROL ACT (TSCA) 8 (B) INVENTORY
All the components of this substance are listed on or are exempt from the inventory. For
purposes of 40 CFR 720.36 , this product is for Research and Development (R&D) Use
Only
TOXIC SUBSTANCES CONTROL ACT, SECTION 12(B) EXPORT NOTIFICATION
40CFR 707, SUBPART D
Not Required.
16. OTHER INFORMATION
Disclaimer: This MSDS has been prepared using information from sources considered technically
reliable. It should not be relied upon as a product specification. The company makes no warranty
of any kind, expressed or implied, concerning the safe use of this material in your process or in
combination with other chemical substances. Every user of the product is responsible for
evaluating its own processes and conditions of use and selecting appropriate protective
measures for employee exposure.
Document no. 100000009880
US MSDS P/N: 4432095a
Print Date 6/4/2009 5:04:00 PM
Revision Date: 06-04-2009
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