SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 07/06/2004
Date Updated: 04/04/2004
Version 1.7
Section 1 - Product and Company Information
Product Name THIMEROSAL
Product Number T5125
Brand SIGMA
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
THIMEROSAL 54-64-8 Yes
Formula C9H9HgO2S.Na
Synonyms ((o-Carboxyphenyl)thio)ethylmercury sodium salt *
Elicide * Ethyl(2-mercaptobenzoato-S)mercury
sodium salt * o-(Ethylmercurithio)benzoic acid
sodium salt * Ethylmercurithiosalicylic acid
sodium salt * Ethylmerkurithiosalicilan sodny
(Czech) * Ethyl (sodium
o-mercaptobenzoato)mercury * Mercurate(1-),
ethyl(2-mercaptobenzoate(2-)-O,S)-, sodium salt *
Mercurothiolate * Mercury,
ethyl(2-mercaptobenzoate-S)-, sodium sal *
Merfamin * Merthiolate * Merthiolate sodium *
Mertorgan * Merzonin * Merzonin sodium * SET *
Sodium ethylmercuric thiosalicylate * Sodium
o-(ethylmercurithio)benzoate * Sodium
ethylmercurithiosalicylate * Sodium merthiolate *
Thimerosal * Thimerosalate * Thiomersal *
Thiomersalate
RTECS Number: OV8400000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Very Toxic (EU).
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. May cause sensitization by
inhalation and skin contact. Irritating to eyes, respiratory
system and skin.
Calif. Prop. 65 reproductive hazard. Target organ(s): Nerves.
Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 1
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 1
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
FLASH POINT
482 癋 250 癈 Method: closed cup
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
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METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.1 MG(HG)/M3
Remarks: Skin
USA MSHA Standard-air TWA 0.05 MG(HG)/M3
USA OSHA. PEL 8H TWA 0.01 MG(HG)/M3
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH Ceiling co0.1 MG/M3 (SK)
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Slightly beige
Form: Powder
Property Value At Temperature or Pressure
Molecular Weight 404.81 AMU
pH 6.7 - 8.2 20 癈 Concentration: 10
g/l
BP/BP Range N/A
MP/MP Range 234 癈
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 0.5 g/cm3
Bulk Density 500 kg/l
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
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Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 482 癋 250 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1 g/ml MeOH Clear
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide
Mercury/mercury oxides., Sulfur oxides
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: May be fatal if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
TARGET ORGAN(S) OR SYSTEM(S)
Nerves. Kidneys.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
98 mg/kg
LD50
Intraaural
Child
60 MG/KG
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LDLO
Remarks: Behavioral:Ataxia. Gastrointestinal:Nausea or vomiting.
Nutritional and Gross Metabolic:Changes in:Metabolic acidosis.
Oral
Rat
75 mg/kg
LD50
Subcutaneous
Rat
98 MG/KG
LD50
Oral
Mouse
91 mg/kg
LD50
Intraperitoneal
Mouse
54 MG/KG
LD50
Subcutaneous
Mouse
66 MG/KG
LD50
Intravenous
Mouse
45 MG/KG
LD50
Remarks: Kidney, Ureter, Bladder:Changes in tubules (including
acute renal failure, acute tubular necrosis).
IRRITATION DATA
Eyes
Rabbit
0.008 mg
Remarks: Mild irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Subcutaneous
Dose: 104 MG/KG
Exposure Time: 1Y
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: Uterine tumors Tumorigenic:Tumors at site or
application.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1300 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
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Species: Rabbit
Dose: 112 MG/KG
Route of Application: Ocular
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 65 UG/KG
Route of Application: Ocular
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 9 MG/L
Cell Type: lymphocyte
Mutation test: SLN
Species: Mouse
Route: Intraperitoneal
Dose: 45 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Route: Intraperitoneal
Dose: 45 MG/KG
Mutation test: SLN
Species: Hamster
Dose: 125 UG/L
Cell Type: lung
Mutation test: Micronucleus test
Species: Hamster
Dose: 900 UG/L
Cell Type: Embryo
Mutation test: Other mutation test systems
Species: Hamster
Dose: 450 UG/L
Cell Type: Embryo
Mutation test: SLN
Species: Hamster
Dose: 125 UG/L
Cell Type: lung
Mutation test: SLN
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 130 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Abortion.
Section 12 - Ecological Information
No data available.
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Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Mercury compounds, solid, n.o.s.
UN#: 2025
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Keep away from food
PIH: Not PIH
IATA
Proper Shipping Name: Mercury compound, solid, n.o.s.
IATA UN Number: 2025
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T+
Indication of Danger: Very toxic.
R: 26/27/28 33
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed. Danger of cumulative effects.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Very Toxic (EU).
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed. Danger of cumulative effects. May cause
sensitization by inhalation and skin contact. Irritating to
eyes, respiratory system and skin.
Safety Statements: Keep away from food, drink, and animal
feedingstuffs. After contact with skin, wash immediately with
plenty of water. In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice. Wear suitable
protective clothing. In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
US Statements: Calif. Prop. 65 reproductive hazard. Target
organ(s): Nerves. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is subject to SARA section 313 reporting
requirements - mercury compounds.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause developmental toxicity.
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CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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