Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
SECTION 1. PRODUCT AND COMPANY IDENTIFICATION
Product name : Genetron?ST-20 Flush
MSDS Number : 000000013778
Product Use Description : Stationary refrigerant flush
Company : Honeywell International, Inc.
101 Columbia Road
Morristown, NJ 07962-1057
For more information call : 800-522-8001
(Monday-Friday, 9:00am-5:00pm)
In case of emergency call : Medical: 1-800-498-5701
: Transportation: 1-800-424-9300 or +1-703-527-3887
: (24 hours/day, 7 days/week)
SECTION 2. HAZARDS IDENTIFICATION
Emergency Overview
Form : liquid
Color : colourless
Odor : slight sweet ether-like
Hazard Summary : This product is not flammable at ambient temperatures and
atmospheric pressure. Vapours are heavier than air and can
cause suffocation by reducing oxygen available for breathing.
Causes asphyxiation in high concentrations. The victim will not
realize that he/she is suffocating. Inhalation may cause central
nervous system effects. May cause cardiac arrhythmia. May
cause drowsiness and dizziness. Do not breathe vapour.
Irritating to eyes and skin. May be harmful if swallowed. Avoid
contact with skin, eyes and clothing. At higher temperatures,
(>250 C), decomposition products may include hydrofluoric
acid (HF) and carbonyl halides. The ACGIH Threshold Limit
Values (2007) for Hydrogen Fluoride are TLV-TWA 0.5 ppm
and Ceiling Exposure Limit 2 ppm.
Potential Health Effects
Skin : Irritating to skin.
Eyes : Irritating to eyes.
Page 1 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
Ingestion : May be harmful if swallowed.
May cause systemic poisoning with symptoms paralleling those
of inhalation.
Inhalation : Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Causes asphyxiation in high concentrations. The victim will not
realize that he/she is suffocating.
Inhalation may cause central nervous system effects.
Vapours may cause drowsiness and dizziness.
Effects of breathing high concentrations of vapour may include:
Cardiac arrhythmias
Chronic Exposure : None known.
Target Organs : Central nervous system
Heart
Liver
Carcinogenicity
No component of this product present at levels greater than or equal to 0.1% is identified as a known or
anticipated carcinogen by NTP, IARC, or OSHA.
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS
Component CAS-No. Weight %
1,1,1,3,3-Pentafluoropropane 460-73-1 40.00 - 70.00
Norflurane 811-97-2 10.00 - 30.00
trans-Dichloroethylene 156-60-5 10.00 - 30.00
SECTION 4. FIRST AID MEASURES
Inhalation : Move to fresh air. If breathing is irregular or stopped, administer
artificial respiration. Use oxygen as required, provided a
qualified operator is present. Call a physician. Do not give drugs
from adrenaline-ephedrine group.
Skin contact : After contact with skin, wash immediately with plenty of water. If
symptoms persist, call a physician. Take off all contaminated
clothing immediately. Wash contaminated clothing before
re-use.
Eye contact : Rinse immediately with plenty of water, also under the eyelids,
Page 2 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
for at least 15 minutes. If symptoms persist, call a physician.
Ingestion : Do not induce vomiting without medical advice. Never give
anything by mouth to an unconscious person. Call a physician
immediately.
Notes to physician
Treatment : Because of the possible disturbances of cardiac rhythm,
catecholamine drugs, such as epinephrine, should be used with
special caution and only in situations of emergency life support.
Treatment of overexposure should be directed at the control of
symptoms and the clinical conditions.
SECTION 5. FIRE-FIGHTING MEASURES
Flash point : not applicable
Lower explosion limit : None
Upper explosion limit : None
Suitable extinguishing : The product is not flammable.
media ASTM D 56-87
Use water spray, alcohol-resistant foam, dry chemical or carbon
dioxide.
Cool closed containers exposed to fire with water spray.
Specific hazards during fire : This product is not flammable at ambient temperatures and
fighting atmospheric pressure.
However, this material can ignite when mixed with air under
pressure and exposed to strong ignition sources.
Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Exposure to decomposition products may be a hazard to health.
In case of fire hazardous decomposition products may be
produced such as:
Carbon monoxide
Carbon dioxide (CO2)
Carbonyl halides
Gaseous hydrogen chloride (HCl).
Gaseous hydrogen fluoride (HF).
Additional advice : This product is a mixture of a low-boiling non-flammable
component and a flammable component. In the event of a liquid
spill, the low-boiling non-flammable component will evaporate
from the mixture faster, leaving a mixture enriched with the
Page 3 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
flammable component. The enriched mixture may be
flammable.
Use extinguishing measures that are appropriate to local
circumstances and the surrounding environment.
SECTION 6. ACCIDENTAL RELEASE MEASURES
Personal precautions : Immediately evacuate personnel to safe areas.
Keep people away from and upwind of spill/leak.
Remove all sources of ignition.
Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Ensure adequate ventilation.
Environmental precautions : Should not be released into the environment.
Do not flush into surface water or sanitary sewer system.
Prevent further leakage or spillage if safe to do so.
Prevent spreading over a wide area (e.g. by containment or oil
barriers).
Methods for cleaning up : Contain spillage, and then collect with non-combustible
absorbent material, (e.g. sand, earth, diatomaceous earth,
vermiculite) and place in container for disposal according to
local / national regulations (see section 13).
SECTION 7. HANDLING AND STORAGE
Handling
Handling : Wear personal protective equipment.
Do not breathe vapours or spray mist.
Avoid contact with skin, eyes and clothing.
Do not use in areas without adequate ventilation.
Perform filling operations only at stations with exhaust
ventilation facilities.
Open drum carefully as content may be under pressure.
Advice on protection against : Can form a combustible mixture with air at pressures above
fire and explosion atmospheric pressure.
Keep product and empty container away from heat and sources
of ignition.
Storage
Requirements for storage : Store away from incompatible substances.
areas and containers Keep away from direct sunlight.
Page 4 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
Keep containers tightly closed in a dry, cool and well-ventilated
place.
Ensure adequate ventilation, especially in confined areas.
Keep in original packaging, tightly closed.
Protect from physical damage.
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Protective measures : Ensure that eyewash stations and safety showers are close to
the workstation location.
Do not breathe vapours or spray mist.
Avoid contact with skin, eyes and clothing.
Engineering measures : Use with local exhaust ventilation.
Perform filling operations only at stations with exhaust
ventilation facilities.
Eye protection : Wear as appropriate:
Safety glasses with side-shields
If splashes are likely to occur, wear:
Goggles or face shield, giving complete protection to eyes
Hand protection : Impervious butyl rubber gloves
Neoprene gloves
Gloves must be inspected prior to use.
Replace when worn.
Skin and body protection : Wear as appropriate:
Solvent-resistant gloves
Solvent-resistant apron and boots
If splashes are likely to occur, wear:
Protective suit
Respiratory protection : In case of insufficient ventilation wear suitable respiratory
equipment.
Wear a positive-pressure supplied-air respirator.
For rescue and maintenance work in storage tanks use
self-contained breathing apparatus.
Hygiene measures : Handle in accordance with good industrial hygiene and safety
practice.
Avoid contact with skin, eyes and clothing.
Ensure adequate ventilation, especially in confined areas.
Remove and wash contaminated clothing before re-use.
Contaminated work clothing should not be allowed out of the
workplace.
Keep working clothes separately.
Wash hands before breaks and immediately after handling the
Page 5 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
product.
Exposure Guidelines
1,1,1,3,3-Pentafluoropro 460-73-1 WEEL TWA 300 ppm 1,644 mg/m3
pane
1,1,1,2-Tetrafluoroethan 811-97-2 WEEL TWA 1,000 ppm 4,240 mg/m3
e
HONEYWELL TWA 1,000 ppm
trans-Dichloroethylene 156-60-5 ACGIH TWA 200 ppm
NIOSH REL 200 ppm 790 mg/m3
OSHA Z1 PEL 200 ppm 790 mg/m3
OSHA Z1A TWA 200 ppm 790 mg/m3
US CA OEL TWA PEL 200 ppm 790 mg/m3
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Form : liquid
Color : colourless
Odor : slight sweet ether-like
pH : neutral
Freezing point : not determined
Boiling point/boiling range : 15 癈 (59 癋)
Vapor pressure : not determined
Relative vapour density : not determined
Density : not determined
Water solubility : not determined
Partition coefficient: : log Pow: 1.35
n-octanol/water
1,1,1,3,3-pentafluoropropane (HFC-245fa)
Page 6 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
Partition coefficient: : log Pow: 1.06
n-octanol/water
1,1,1,2-tetrafluoroethane (HFC-134a)
SECTION 10. STABILITY AND REACTIVITY
Conditions to avoid : Protect from heat/overheating.
Keep away from direct sunlight.
Heat, flames and sparks.
Materials to avoid : Calcium
Magnesium
Aluminium
Zinc
Potassium
Finely divided aluminium
Hazardous decomposition : Halogenated compounds
products Carbonyl halides
Carbon dioxide (CO2)
Hydrogen halides
Hazardous reactions : Hazardous polymerisation does not occur.
Stable under normal conditions.
SECTION 11. TOXICOLOGICAL INFORMATION
Acute oral toxicity : LD50 rat
Dose: 1,235 mg/kg
Test substance: trans-Dichloroethylene
Acute dermal toxicity : LD50 rabbit
Dose: > 2,000 mg/kg
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Acute dermal toxicity : LD50 rabbit
Dose: > 5,000 mg/kg
Test substance: trans-Dichloroethylene
Acute inhalation toxicity : LC50 rat
Dose: > 24100 ppm
Exposure time: 4 h
Test substance: trans-Dichloroethylene
Acute inhalation toxicity : LC50 rat
Dose: > 500000 ppm
Page 7 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
Exposure time: 4 h
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
Acute inhalation toxicity : LC50 rat
Dose: > 200000 ppm
Exposure time: 4 h
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
No deaths
Evidence of transient anesthetic effect.
Acute inhalation toxicity : LC50 mouse
Dose: > 100000 ppm
Exposure time: 4 h
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
No deaths
Evidence of transient underactivity during exposure.
Skin irritation : rabbit
Moderate skin irritation
Test substance:trans-Dichloroethylene
Eye irritation : rabbit
Moderate eye irritation
Test substance: trans-Dichloroethylene
Sensitisation : Cardiac sensitization dogs
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
No effects noted at 35,000 ppm, the threshold for induction of
cardiac arrhythmias in the presence of injected adrenalin was
44,000 ppm.
Repeated dose toxicity : rat Not a teratogen
NOEL: 50,000 ppm
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Embryotoxicity
Repeated dose toxicity : rat (pups)
NOEL: 50,000 ppm
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Repeated dose toxicity : rat (dams) due to decrease in body weight gains at 10,000 ppm
and 50,000 ppm
NOEL: 2,000 ppm
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Repeated dose toxicity : rat Exposures 6hrs/day, 7 days/wk at 0(control), 2000, 10,000
and 50,000 ppm.
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
2 Generation Inhalation Toxicity
Page 8 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
Repeated dose toxicity : rat (dams) Toxicity seen in dams at 10,000 and 50,000 ppm
and in pups at 50,000 ppm., Increased mortality late in the
lactation phase of the study.
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Repeated dose toxicity : rat 28-day Inhalation Study, NOEL - 500 ppm, Dose levels:
0,500, 2000, 10,000 and 50,000 ppm
NOEL: 50,000 ppm
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Repeated dose toxicity : rat 90-day Inhalation Study, Dose levels: 0,500, 2000, 10,000
and 50,000 ppm
NOEL: 2,000 ppm
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Repeated dose toxicity : Overall, subchronic studies showed dose-related increases in
urinary fluoride levels, urine volumes and water consumption.
Increases were noted in hematological parameters, BUN levels
and serum liver enzyme activities (GOT, GPT). These increases
did not follow a dose response; however, they indicate that
HFC-245fa is metabolized in the liver. Significant recovery was
noted in these parameters following a 2-week, non-exposure
period which followed the 28-day exposure period. No
histopathological effects were noted in the 28-day study. The
90-day study noted an increase in incidence and severity (trace
to moderate) of mycarditis (inflammation of the heart muscle) at
10,000 and 50,000 ppm. This was not noted at the 500 or 2,000
ppm dose levels nor was it seen the 28-day study at 50,000
ppm.
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Repeated dose toxicity : Inhalation rat Subchronic toxicity
NOEL: 50,000 ppm
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
Repeated dose toxicity : Inhalation rat Chronic toxicity
NOEL: 10,000 ppm
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
Repeated dose toxicity : rat Teratogenicity
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
Repeated dose toxicity : rabbit Teratogenicity
NOEL: 40,000 ppm
Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
Repeated dose toxicity : rat 90-day Inhalation Study
NOEL: 4,000 ppm
Test substance: trans-Dichloroethylene
Page 9 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
Repeated dose toxicity : rat Not a teratogen, Foetal toxicity, at maternally toxic
concentrations.
Test substance: trans-Dichloroethylene
Embryotoxicity
Repeated dose toxicity : rat (pups) Skeletal malformation, decrease in body weight
NOEL: 12,000ppm
Test substance: trans-Dichloroethylene
Repeated dose toxicity : rat (dams)
NOEL: 6,000 ppm
Test substance: trans-Dichloroethylene
Genotoxicity in vitro : Test substance: 1,1,1,2-tetrafluoroethane (HFC-134a)
In vitro tests did not show mutagenic effects
Genotoxicity in vitro : Test substance: trans-Dichloroethylene
In vitro tests did not show mutagenic effects
Genotoxicity in vitro : Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
In vitro tests did not show mutagenic effects
Genotoxicity in vivo : Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
In vivo tests did not show mutagenic effects
Additional advice : 1,1,1,2-tetrafluoroethane (HFC-134a): Cardiac sensitisation
threshold (dog): 80000 ppm.
SECTION 12. ECOLOGICAL INFORMATION
Toxicity to fish : LC50
Species: Oncorhynchus mykiss (rainbow trout)
Dose: > 81.8 mg/l
Exposure time: 96 h
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Toxicity to daphnia and : EC50
other aquatic invertebrates. Species: Daphnia
Dose: > 97.9 mg/l
Exposure time: 48 h
Test substance: 1,1,1,3,3-pentafluoropropane (HFC-245fa)
Additional ecological : This product is subject to U.S. Environmental Protection Agency
information Clean Air Act Regulations at 40 CFR Part 82.
This product contains greenhouse gases which may contribute
to global warming. Do NOT vent to the atmosphere. To comply
with provisions of the U.S. Clean Air Act, any residual must be
Page 10 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
recovered.
Refer to sections 610 and 612 for list of acceptable and
unacceptable uses for this product.
Further information on ecology:
SECTION 13. DISPOSAL CONSIDERATIONS
Waste Information: Observe all Federal, State, and Local Environmental regulations.
SECTION 14. TRANSPORT INFORMATION
UN-Number : 3082
DOT
Proper shipping name : ENVIRONMENTALLY HAZARDOUS
SUBSTANCE, LIQUID, N.O.S.
(1,2-Dichloroethylene)
Class 9
Packing group III
Hazard Label 9
Package containing > Reportable Quantity
Not dangerous goods
TDG
UN Number : 3163
IATA
Description of the goods : LIQUEFIED GAS, N.O.S.
(1,1,1,3,3-Pentafluoropropane,
1,1,1,2-Tetrafluoroethane)
Class : 2.2
Hazard Label : 2.2
Packing instruction (cargo : 200
aircraft)
Packing instruction : 200
(passenger aircraft)
Substance No. : UN 3163
IMDG
Description of the goods : LIQUEFIED GAS, N.O.S.
(1,1,1,3,3-PENTAFLUOROPROPANE,
1,1,1,2-TETRAFLUOROETHANE)
Class : 2.2
Hazard Label : 2.2
EmS Number : F-C
Marine pollutant : no
SECTION 15. REGULATORY INFORMATION
Inventories
Page 11 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
EU. EINECS : The formulation contains ELINCS substances.
: 1,1,1,3,3-Pentafluoropropane 460-73-1
US. Toxic Substances : On TSCA Inventory
Control Act
Australia. Industrial : On the inventory, or in compliance with the inventory
Chemical (Notification and
Assessment) Act
Canada. Canadian : All components of this product are on the Canadian DSL list.
Environmental Protection
Act (CEPA). Domestic
Substances List (DSL).
(Can. Gaz. Part II, Vol. 133)
Japan. Kashin-Hou Law List : On the inventory, or in compliance with the inventory
Korea. Toxic Chemical : On the inventory, or in compliance with the inventory
Control Law (TCCL) List
Philippines. The Toxic : Not in compliance with the inventory
Substances and Hazardous
and Nuclear Waste Control
Act
: 1,1,1,3,3-Pentafluoropropane 460-73-1
China. Inventory of Existing : Not in compliance with the inventory
Chemical Substances
: 1,1,1,3,3-Pentafluoropropane 460-73-1
National regulatory information
: trans-Dichloroethylene 156-60-5
SARA 313 Components
: Acute Health Hazard
SARA 311/312 Hazards
Sudden Release of Pressure Hazard
: 6452 lbs
CERCLA Reportable
Quantity
Page 12 / 13
Material Safety Data Sheet
Genetron?ST-20 Flush
Version 1 Revision Date 04/07/2009 Print Date 05/19/2009
: This product does not contain any chemicals known to State of
California Prop. 65
California to cause cancer, birth, or any other reproductive
defects.
: trans-Dichloroethylene 156-60-5
Massachusetts RTK
: trans-Dichloroethylene 156-60-5
New Jersey RTK
: trans-Dichloroethylene 156-60-5
Pennsylvania RTK
SECTION 16. OTHER INFORMATION
HMIS III NFPA
Health Hazard :2 2
Flammability :1 1
Physical Hazard :1
Instability : 1
Page 13 / 13
|