AMVAC CHEMICAL CORPORATION Page 1 of 9
LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME: LORSBAN?15G SMARTBOX?br>
CHEMICAL NAME (Active Ingredient): O,O-Diethyl O-(3,5,6-trichloro-2-
pyridinyl) phosphorothioate
SYNONYMS (for active ingredient): Chlorpyrifos, Lorsban?br>
GENERAL USE: Organophosphorus pesticide
PRODUCT DESCRIPTION: Beige granules
EPA Registration Number: 5481-525
MSDS No.: 343_1
Current Revision Date: 16 March, 2006
MANUFACTURER: EMERGENCY TELEPHONE NUMBERS:
AMVAC CHEMICAL CORPORATION MANUFACTURER: 323-264-3910
4100 E. Washington Blvd. TRANSPORTATION (24 HOURS)
Los Angeles, CA 90023-4406 CHEMTREC: 800-424-9300
Ph: 323-264-3910 OTHER (24 HOURS)
FAX: 323-268-1028 AMVAC: 323-264-3910
2. COMPOSITION/INFORMATION ON INGREDIENTS
COMPONENT WT % CAS No.
Chlorpyrifos; O,O-Diethyl O-(3,5,6-trichloro-2- 15% 2921-88-2
pyridinyl) phosphorothioate
Inert Ingredients 85%
Includes gamma-Butyrolactone and 96-48-0
clay (which may contain crystalline silica) 14808-60-7
OSHA HAZARDOUS COMPONENTS (29 CFR1910.1200)
COMPONENT HAZARD OSHA ACGIH
PEL*(skin) TLV*(skin)
0.2 mg/m3 0.2 mg/m3
Chlorpyrifos POISON
0.1 mg/m3 0.05 mg/m3
Respirable crystalline quartz Carcinogen, irritation
(CAS No. 14808-60-7)
15 mg/m3 10 mg/m3
Nuisance Dust, Total Irritation
(Inhalable)
* Exposure Limits 8 hrs. TWA
LORSBAN is a registered trademark of Dow AgroSciences.
SMARTBOX is a registered trademark of AMVAC Chemical Corporation.
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW:
CAUTION! Cholinesterase Inhibitor. Inhalation or skin contact may, without
symptoms, progressively increase susceptibility to Chlorpyrifos
(LORSBAN? poisoning. Do not swallow or get in eyes, on skin or on
clothing. Do not breathe dust.
Keep out of reach of children! Do not contaminate food or feed products.
Toxic to fish, birds and other wildlife. Do not contaminate bodies of water.
POTENTIAL HEALTH EFFECTS
ROUTE(S) OF ENTRY: Poisonous if swallowed, inhaled or absorbed through skin. Repeated
inhalation or skin contact may, without symptoms, progressively increase susceptibility to
Chlorpyrifos poisoning.
SIGNS OF ACUTE OVEREXPOSURE: Symptoms include weakness, headache, tightness in
chest, blurred vision, non-reactive pinpoint pupils, salivation, sweating, nausea, vomiting,
diarrhea, and abdominal cramps. In extreme cases unconsciousness, convulsions, severe
respiratory depression and death may occur.
SIGNS OF CHRONIC OVEREXPOSURE: Repeated exposures to small doses of Chlorpyrifos
(LORSBAN? and other organophosphates may lower the cholinesterase to levels where
the above symptoms of acute overexposure are observed.
OTHER POTENTIAL HEALTH EFFECTS: Laboratory studies have shown no carcinogenic
and reproductive effects in laboratory animals.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Preexisting skin or respiratory
disorders may be aggravated by exposure to components of this product. Preexisting
conditions which lower cholinesterase levels increase vulnerability to cholinesterase
depression. These include: (for plasma) chronic alcoholism; malnutrition;
dermatomyositis; existing toxicity from exposure to carbon disulfide; benzalkonium salts,
organic mercury compounds, ciguatoxins or solanines; and (for RBC) hemolytic anemia.
CARE SHOULD BE TAKEN WHEN HANDLING CHLORPYRIFOS AND ITS
FORMULATIONS.
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
4. FIRST AID MEASURES
CHLORPYRIFOS (LORSBAN? IS A CHOLINESTERASE INHIBITOR. A PHYSICIAN
SHOULD BE CONTACTED IN ALL CASES OF OVEREXPOSURE TO
CHLORPYRIFOS AND ITS FORMULATIONS IF ANY OF THE SYMPTOMS LISTED
IN SECTION 3 ARE OBSERVED. WEAR PROTECTIVE EQUIPMENT WHEN
TREATING SOMEONE OVEREXPOSED TO CHLORPYRIFOS TO PREVENT
EXPOSURE OF THE RESCUER.
EYES: Immediately flush the eyes with copious amounts of clear, cool running water for a
minimum of 15 minutes. Hold the eyelids apart during the flushing to ensure rinsing of
the entire surface of the eyes and lids with water. Contact a physician immediately. If
there will be a delay in getting medical attention, rinse the eyes for at least another 15
minutes.
INHALATION: Remove victim to fresh air if symptoms are observed. If breathing has ceased,
clear the victim's airway and start mouth-to-mouth artificial respiration. If breathing is
difficult, give oxygen. Contact a physician immediately. Be sure the contact areas are
clean to prevent contamination of the rescuer.
INGESTION: Contact a physician or poison control center immediately. Immediately dilute the
swallowed product by giving large quantities of water (at least 1 to 2 large glasses).
Induce vomiting by giving Syrup of Ipecac according to directions on the bottle or by
touching a finger to the back of the throat. Never give anything by mouth to an
unconscious or convulsing person. Be sure the mouth is clean or wear a rubber glove to
prevent contamination of the rescuer.
SKIN: Wash affected areas thoroughly with soap and water. Remove contaminated clothing. Do
not attempt to neutralize with chemical agents. Wash clothing before reuse. If skin
irritation develops, contact a physician immediately.
NOTE TO PHYSICIANS: This is an Organophosphate (OP) Insecticide. Do not wait for
laboratory confirmation to treat patients with strong clinical evidence of poisoning. In the
USA and other countries, contact your local or national poison control center for more
information.
Do Not handle the patient without the following protective equipment in place: chemical
resistant gloves and apron (preferably nitrile). Remove contaminated clothing and do not
reuse without thorough cleaning with detergent and hot water. Dispose of heavily
contaminated clothing, including shoes, as a hazardous waste.
Establish airway and oxygenation. IV Atropine sulfate is the antidote of choice against
parasympathetic nervous stimulation. If there are signs of parasympathetic stimulation,
Atropine Sulfate should be injected at 10 minute intervals in doses of 1 to 2 milligrams
until complete atropinization has occurred. Pralidoxime chloride (2-PAM chloride) may
also be used as an effective antidote in addition to and while maintaining full
atropinization. In adults, an initial dose of 1 gram of 2-PAM should be injected,
preferably as an infusion, in 250 cc of saline over a 15 to 20 minute period. If this is not
practical, 2-PAM may be administered slowly by intravenous injection as a 5% solution
in water over not less than 2 minutes. After about an hour, a second dose of 1 gram of 2-
PAM will be indicated if muscle weakness has not been relieved. For infants and
children, the dose of 2-PAM is 0.25 grams. Avoid morphine, aminophylline,
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
4. FIRST AID MEASURES, cont'd
phenothiazine, reserpine, furosemide and ethacrynic acid. Clear chest by postural
drainage. Oxygen administration may be necessary. Observe patient continuously for 48
hours. Repeated exposure to cholinesterase inhibitors may without warning cause
prolonged susceptibility to very small doses of any cholinesterase inhibitor. Allow no
further exposure until time for cholinesterase regeneration has been attained as
determined by a blood test.
Bathe and shampoo contaminated skin and hair. If ingested, empty stomach; activated
charcoal is useful to further limit absorption. If victim is alert, Syrup of Ipecac (2
tablespoons in adults, 1 tablespoon in small children) followed by water (2 glasses for
adults, 1 glass for children) is indicated. If symptoms such as loss of gag reflex,
convulsions, or unconsciousness occur before emesis, gastric lavage should be considered
following intubation with a cuffed endotracheal tube.
5. FIRE FIGHTING MEASURES
FLAMMABLE PROPERTIES
Flash Point: Not applicable
Autoignition Temperature: Not applicable
Flammable Limits:
Lower flammable limit: Not determined
Upper flammable limit: Not determined
Flammability: This is a noncombustible granule coated with an organic compound
that will support fire in a direct flame (NFPA rating = 1)
EXPLOSIVITY
Mechanical Impact: Not explosive
Static Discharge: Will not occur
HAZARDOUS COMBUSTION PRODUCTS: Heating or burning may release toxic vapors or
fumes. Containers exposed to intense heat from fires should be cooled with water to
prevent vapor pressure buildup, which could result in container rupture.
EXTINGUISHING MEDIA: Water fog, "Alcohol" Foam, Dry Chemical, CO2.
FIRE FIGHTING INSTRUCTIONS: Evacuate nonessential personnel to a safe area upwind of
the fire. Wear self-contained breathing apparatus. Wear full protective equipment to
prevent skin contact. Runoff from fire control may be a pollution hazard. Wash all
equipment thoroughly with detergent and water before reuse.
6. ACCIDENTAL RELEASE MEASURES
GENERAL: Evacuate personnel and thoroughly ventilate the area. Use adequate ventilation and
appropriate personal protective equipment (PPE, Section 8). Keep bystanders upwind
and away from the spill.
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
6. ACCIDENTAL RELEASE MEASURES, cont'd
SMALL SPILL: Sweep or shovel into an open drum. Decontaminate the area and equipment
with dilute alkali or ammonia (less than 5% solution) and detergent. Absorb and sweep
into the same open drum. Rinse with water, absorb, and add to the waste drum. Close
the drum and dispose of properly, according to hazardous waste disposal procedures for
your locality.
LARGE SPILL: Dike the spill to prevent contamination of local water sources. Sweep, vacuum,
or shovel the spilled granules into drums for use or disposal, depending on the
circumstances. Clean the area as described for a small spill.
7. HANDLING AND STORAGE
HANDLING: Avoid exposure to dust and vapors by wearing appropriate personal protective
equipment (PPE, section 8) and adequate ventilation. Always wash hands, face, and arms
with soap and water before smoking, eating, drinking, or going to the toilet.
STORAGE: Store in the original container in a secure, temperate, dry place. Store below 100/F.
Keep away from heat and open flame. Do not contaminate water, food, or feed. Do not
contaminate bodies of water.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
ENGINEERING CONTROLS: Ventilation should be sufficient to keep exposures to vapors
below the TLV for the hazardous ingredients of this product (see Section 2). Use of
mechanical or local exhaust systems is recommended.
RESPIRATORY PROTECTION: When respiratory protection is required, or concentrations
may exceed the TLV or PEL, use a NIOSH/MSHA approved air-purifying respirator
equipped with organic vapor cartridges or canisters. It is recommended that the canisters
be changed whenever breakthrough occurs or eight (8) hours of use has occurred,
whichever comes first. For emergency and other conditions where the exposure limit may
be greatly exceeded, use an approved positive-pressure, self-contained breathing
apparatus or positive-pressure airline with auxiliary self-contained air supply.
SKIN PROTECTION: Prevent skin contact. Chemical resistant gloves(preferably nitrile),
coveralls or long-sleeved shirt and pants, and chemical resistant shoes or boots, are
necessary to prevent skin contamination. Remove contaminated clothing as soon as
possible. Wash dirty or contaminated clothing separately from other clothes. Wear clean
clothes daily. Wash well with soap and water after handling this product. See the label
for more specific instructions.
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
8. EXPOSURE CONTROLS/PERSONAL PROTECTION, cont'd
EYE PROTECTION: Safety glasses should be worn whenever working with chemicals. In
addition, goggles or a faceshield are required if there is a chance of dust formation.
OTHER PROTECTION: There should be an eyewash station and a safety shower in the work
area.
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Appearance: Tan/buff colored granule
Odor: Skunk-like (Mercaptan-like)
Odor Threshold: Not available
Boiling Point: Not applicable
Freezing/Melting Point: Not applicable
Density: 45 lb/cu. ft.
Vapor Pressure: 2.7 mPa @ 25/C (a.i.)
Vapor Density: Heavier than air
Percent Volatile by Vol: Not available
Solubility (Water): Negligible
Solubility (Other): The active ingredient is soluble in aromatic hydrocarbons,
alcohols, ketones, ethers, and chlorinated solvents
Partition Coefficient (O/W): 50000 (Kow) (a.i.)
pH: Not available
Reactivity with Water: Slowly decomposes (hydrolysis) over several days (a.i)
Evaporation Rate: Not available
10. STABILITY AND REACTIVITY
CHEMICAL STABILITY (Conditions to avoid): Stable at normal temperatures and storage
conditions. Store below 100/F (38/C)
CONDITIONS TO AVOID: Avoid temperatures above 158/F (70/C). Chlorpyrifos decomposes
at elevated temperatures.
INCOMPATIBILITY: Strong oxidizers and strongly alkaline materials.
HAZARDOUS DECOMPOSITION PRODUCTS: Thermal decomposition products may
include but are not limited to hydrogen chloride, organic sulfides, and sulfur dioxide.
HAZARDOUS POLYMERIZATION: This product will not polymerize.
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
11. TOXICOLOGICAL INFORMATION
INGESTION: Oral LD50 (rat): 2250/1288 mg/kg (male/female)
INHALATION: Inhalation LC50 (rat): >0.2 mg/L (4-6 hr, for a.i. only)
DERMAL: Skin LD50 (rabbit): > 5000 mg/kg
IRRITATION: Eye irritation (rabbit): Moderate irritation, may be slow to heal.
Corneal injury is unlikely.
Skin irritation (rabbit): Minimal irritation
SENSITIZATION: Skin sensitization: Not considered to have significant
(guinea pig) sensitization potential
TERATOGENICITY: Testing of Chlorpyrifos and gamma-Butyrolactone showed no evidence of
teratogenicity in laboratory animals.
MUTAGENICITY: Based on a majority of negative data and some equivocal or marginally
positive results, Chlorpyrifos is considered to have minimal mutagenic potential. For the
minor components(s), in-vitro mutagenicity studies were negative in some cases and
positive in other cases.
CARCINOGENICITY: Chlorpyrifos and gamma-Butyrolactone did not cause cancer in
laboratory animals. IARC, NTP, and OSHA all list crystalline silica as being
carcinogenic.
REPRODUCTIVE TOXICITY: Chlorpyrifos did not interfere with fertility in reproduction
studies in laboratory animals. Some evidence of toxicity to the offspring occurred, but
only at a dose high enough to produce significant toxicity to the parent animals. Gamma-
butyrolactone has been shown to produce testicular effects in laboratory animal studies,
which suggest that excessive exposure to the component may interfere with reproduction.
TOXICOLOGICAL SYNERGISTIC PRODUCTS: No data are available.
12. ECOLOGICAL INFORMATION
GENERAL: This product is highly toxic to fish and wildlife. Keep out of surface waters, sewers,
and waterways entering or leading to surface waters. Notify authorities if any exposure to
the general public or environment occurs or is likely to occur.
13. DISPOSAL CONSIDERATIONS
WASTE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess
pesticide, spray mixture or rinsate is a violation of Federal law. If these wastes cannot be
disposed by use according to label instructions, contact your nearest State Pesticide or
Environmental Control Agency, the Hazardous Waste representative at the nearest EPA
regional office or national equivalent to these agencies, for guidance. Open dumping is
prohibited.
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
13. DISPOSAL CONSIDERATIONS, cont'd
CONTAINER DISPOSAL: Do not discard "SMARTBOXTM" container. All "SMARTBOXTM"
containers must be returned to the place where they were purchased. Contact AMVAC
Customer Service (800-GO AMVAC) for instructions in the event any difficulty in return
of the "SMARTBOXTM" is experienced. Do not attempt to open or tamper with the
"SMARTBOXTM". Once empty, the "SMARTBOXTM" is not intended for reuse by the
user.
14. TRANSPORTATION INFORMATION
DOT Class: 9
UN Number: NA3077
IMDG Class (sea): 9
IATA Class (air): 9
Marine Pollutant: Yes (Severe)
Packing Group: III
Hazard Label(s): Class 9 (Miscellaneous Hazardous Materials)
ADR Class (road): 9
Proper Shipping Name(s): Other regulated substances, solid, n.o.s.,
(Chlorpyrifos)
Reportable Quantity: Yes (1 lb Chlorpyrifos = 6.7 lb product)
(DOT, 172.101, Appendix A)
PACKAGING
General Description: 50 lb "SMARTBOXTM"
15. REGULATORY INFORMATION
U.S. FEDERAL REGULATIONS: This product is registered under EPA/FIFRA Regulations as
a RESTRICTED USE PESTICIDE. It is a violation of Federal Law to use this product in
any manner inconsistent with its labeling. Read and follow all label directions. This
product is excluded from listing requirements under EPA/TSCA.
SARA TITLE III DATA
Section 311 & 312 Hazard Categories:
Immediate Health Hazard: Yes
Delayed Health Hazard: Yes
Fire Hazard: No
Reactive Hazard: No
Sudden Pressure Release Hazard: No
Section 302 Extremely Hazardous Substances: None
Section 313 Toxic Chemicals: None
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LORSBAN?15G SMARTBOX? AMVAC MSDS No. 343_1
15. REGULATORY INFORMATION, cont'd
CERCLA Reportable Quantity (RQ): Chlorpyrifos (CAS No. 2921-88-2)
RQ - 1 lbs; Product - 6.7 lbs
EPCRA Threshold Planning Quantity TPQ): None
STATE REGULATIONS:
CALIFORNIA (Proposition 65): This product contains a chemical known to the state of
California to be carcinogenic: Crystalline silica.
16. OTHER INFORMATION
MSDS Status:
Date This Revision: 16 March, 2006
Date Previous Revision: New MSDS
Person Responsible for Preparation: Gary A. Braden
Reasons for Revision: New product for AMVAC Chemical Corporation.
DISCLAIMER: This information is provided for the limited guidance to the user. While
AMVAC believes that the information is, as of the date hereof, reliable, it is the user's
responsibility to determine the suitability of the information for its purposes. The user is
advised not to construe the information as absolutely complete since additional
information may be necessary or desirable when particular, exceptional, or variable
conditions or circumstances exist (like combinations with other materials), or because of
applicable regulations. No express or implied warranty of merchantability or fitness for a
particular purpose or otherwise is made hereunder with respect to the information or the
product to which the information relates.
ABBREVIATIONS:
ACGIH - American Conference of Governmental Industrial Hygienists
ADR - European Agreement Concerning the International Carriage of
Dangerous Goods by Road
CERCLA - Comprehensive Environmental Response, Compensation, and
Liability Act
DOT - Department of Transportation
EHS - Extremely Hazardous Substances
EPA - Environmental Protection Agency
EPCRA - Emergency Planning and Community Right-to-Know Act
FIFRA - Federal Insecticide, Fungicide, and Rodenticide Act
IARC - International Agency for Research on Cancer
IATA - International Air Transport Association
IMDG - International Maritime Dangerous Goods
NTP - National Toxicology Program
OSHA - Occupational Safety and Health Agency
SARA - Superfund Amendments and Reauthorization Act
TSCA - Toxic Substances Control Act
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