Safety data sheet
Page: 1/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
1. Substance/preparation and company identification
Vitamin A-Palmitate 1.0 Mio IU/G
Use: cosmetic ingredient
Company:
BASF SE
67056 Ludwigshafen
GERMANY
Care Chemicals
Telephone: +49 621 60-28444
Telefax number: +49 621 60-28189
E-mail address: EM-Masterdata@basf.com
Emergency information:
Telephone: +49 180 2273-112
Telefax number: +49 621 60-92664
2. Composition/information on ingredients
Chemical nature
Preparation based on: retinyl palmitate
dissolved in: sunflower oil
stabilized with: DL-Alpha-Tocopherol
Hazardous ingredients
Retinol, hexadecanoate
Content (W/W): 58 %
CAS Number: 79-81-2
EC-Number: 201-228-5
Hazard symbol(s): T
R-phrase(s): 38, 61
Page: 2/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
The wording of the hazard symbols and R-phrases is specified in chapter 16 if dangerous ingredients
are mentioned.
3. Hazard identification
Irritating to skin.
May cause harm to the unborn child.
4. First-aid measures
General advice:
Remove contaminated clothing.
If inhaled:
Keep patient calm, remove to fresh air, seek medical attention.
On skin contact:
Immediately wash thoroughly with soap and water, seek medical attention.
On contact with eyes:
Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open,
consult an eye specialist.
On ingestion:
Rinse mouth immediately and then drink plenty of water, seek medical attention.
Note to physician:
Treatment: Symptomatic treatment (decontamination, vital functions).
5. Fire-fighting measures
Suitable extinguishing media:
water spray, carbon dioxide, dry extinguishing media, foam
Special protective equipment:
Wear a self-contained breathing apparatus.
Further information:
Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.
6. Accidental release measures
Environmental precautions:
Do not discharge into drains/surface waters/groundwater.
Page: 3/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
Methods for cleaning up or taking up:
For small amounts: Contain with absorbent material (e.g. sand, silica gel, acid binder, general
purpose binder, sawdust). Sweep/shovel up. After taking up material in containers, cover
immediately with water layer.
For large amounts: Dike spillage. Vacuum up spilled product. Contain with absorbent material (e.g.
sand, silica gel, acid binder, general purpose binder, sawdust). Sweep/shovel up. After taking up
material in containers, cover immediately with water layer.
Dispose of absorbed material in accordance with regulations.
7. Handling and storage
Storage
Further information on storage conditions: Keep container tightly closed and dry; store in a cool
place. Protect from air. Protect from the effects of light.
Protect from temperatures above: 60 癈
Changes in the properties of the product may occur if substance/product is stored above indicated
temperature for extended periods of time.
8. Exposure controls and personal protection
Components with workplace control parameters
none
Personal protective equipment
Respiratory protection:
Respiratory protection in case of vapour/aerosol release. Combination filter EN 141 Type A-P2
(gases/vapours of organic compounds and solid and liquid particles).
Hand protection:
Suitable chemical resistant safety gloves (EN 374) also with prolonged, direct contact
(Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to
EN 374): E.g. nitrile rubber (0.4 mm), chloroprene rubber (0.5 mm), polyvinylchloride (0.7 mm) and
other
Supplementary note: The specifications are based on own tests, literature data and information of
glove manufacturers or are derived from similar substances by analogy. Due to many conditions
(e.g. temperature) it must be considered, that the practical usage of a chemical-protective glove in
practice may be much shorter than the permeation time determined in accordance with EN 374.
Eye protection:
Safety glasses with side-shields (frame goggles) (EN 166)
General safety and hygiene measures:
Under no circumstances should the product come into contact with the skin of pregnant women or be
inhaled by them. Handle in accordance with good industrial hygiene and safety practice.
Page: 4/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
9. Physical and chemical properties
Form: liquid to semi-crystalline
Colour: light yellow
Odour: mild
softening range: approx. 30 - 40 癈
The substance / product
decomposes.
Flash point: > 100 癈 (DIN 51758)
Ignition temperature: approx. 265 癈 (DIN 51794)
Density: 0.88 g/cm3
(20 癈)
Solubility in water: insoluble
Solubility (qualitative) solvent(s): organic solvents
soluble
Partitioning coefficient n-octanol/water (log Pow): > 6 (calculated)
(25 癈)
Viscosity, dynamic: 27 mPa.s
(60 癈)
10. Stability and reactivity
Hazardous reactions:
When finely distributed, self-ignition is possible.
The product is stable if stored and handled as prescribed/indicated.
Hazardous decomposition products:
No hazardous decomposition products if stored and handled as prescribed/indicated.
11. Toxicological information
LD50/oral/rat/male/female: > 2,000 mg/kg (BASF-Test)
The product has not been tested. The statement has been derived from products of a similar
structure and composition.
Primary skin irritation/rabbit: Irritant. (BASF-Test)
Primary irritations of the mucous membrane/rabbit: non-irritant (OECD Guideline 405)
Animal studies do not fully exclude a skin sensitizing potential.
The product has not been tested. The statement has been derived from products of a similar
structure and composition.
Page: 5/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
Further information:
In the majority of tests performed (microorganisms) a mutagenic effect was not found. A mutagenic
effect was also not observed in in-vivo assays.
Literature data.
Results from a number of long-term carcinogenity studies and short-term tests are available. Taking
into account all of the information, there is no indication that the substance itself is carcinogenic.
Literature data.
In animal studies the substance showed a developmental toxic/teratogenic effect.
Literature data.
12. Ecological information
Ecotoxicity
Toxicity to fish:
DIN 38412 Part 15 static
Leuciscus idus/LC50 (96 h): > 100 mg/l
The details of the toxic effect relate to the nominal concentration. The product has not been tested.
The statement has been derived from products of a similar structure and composition.
Aquatic invertebrates:
Directive 79/831/EEC static
Daphnia magna/EC50 (48 h): 35.34 mg/l
The details of the toxic effect relate to the nominal concentration. The product has low solubility in
the test medium. An aqueous solution prepared with solubilizers has been tested.
Aquatic plants:
DIN 38412 Part 9 static
Scenedesmus subspicatus/EC50 (72 h): 25.57 mg/l
The details of the toxic effect relate to the nominal concentration. The product has low solubility in
the test medium. An aqueous solution prepared with solubilizers has been tested.
Microorganisms/Effect on activated sludge:
DIN 38412 Part 27 (draft) aquatic
Pseudomonas putida/EC10 (30 min): > 10,000 mg/l
The details of the toxic effect relate to the nominal concentration. The product has low solubility in
the test medium. An aqueous solution prepared with solubilizers has been tested.
DIN/EN/ISO 8192-OECD 209-88/302/EEC,P. C aerobic
activated sludge, domestic/EC20 (30 min): > 1,000 mg/l
Assessment of aquatic toxicity:
Acutely harmful for aquatic organisms.
The inhibition of the degradation activity of activated sludge is not anticipated when introduced to
biological treatment plants in appropriate low concentrations.
Page: 6/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
Persistence and degradability
Elimination information
Test method: OECD Guideline 301 F (aerobic), activated sludge, domestic
Method of analysis: BOD of the ThOD
Degree of elimination: 50 - 60 % (28 d)
Assessment: Not readily biodegradable (by OECD criteria). Moderately/partially
biodegradable.
Bioaccumulation potential
Accumulation in organisms is expected.
13. Disposal considerations
Observe national and local legal requirements.
14. Transport information
Not classified as hazardous under transport regulations ( ADR RID ADNR IMDG/GGVSee
ICAO/IATA )
15. Regulatory information
Regulations of the European union (Labelling) / National legislation/Regulations
Hazard symbol(s)
T Toxic.
R-phrase(s)
R61 May cause harm to the unborn child.
R38 Irritating to skin.
S-phrase(s)
S53 Avoid exposure - obtain special instructions before use.
Hazard determinant component(s) for labelling: VITAMIN-A-PALMITATE
Other regulations
Page: 7/7
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 21.02.2005 Version: 1.2
Product: Vitamin A-Palmitate 1.0 Mio IU/G
(30054579/SDS_COS_EU/EN)
Date of print 27.02.2008
16. Other information
Full text of hazard symbols and R-phrases if mentioned as hazardous components in chapter 2:
T Toxic.
38 Irritating to skin.
61 May cause harm to the unborn child.
Vertical lines in the left hand margin indicate an amendment from the previous version.
The information contained herein is based on the present state of our knowledge and does not therefore
guarantee certain properties. Recipients of our product must take responsibility for observing existing
laws and regulations.
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