Safety data sheet
Page: 1/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
1. Substance/preparation and company identification
Vitamin Mischung oelig 02/185
Use: Vitamin
Company:
BASF Aktiengesellschaft
Fine Chemicals Division
67056 Ludwigshafen, Germany
E-mail address: basis-msds-label.me-qr@basf-ag.de
Emergency information:
Fire brigade BASF Ludwigshafen
Telephone: +49-621-60-43333
Telefax number: +49-621-60-92664
2. Composition/information on ingredients
Chemical nature
vitamin blend, retinyl palmitate, cholecalciferol
dissolved in: sunflower oil
stabilized with: DL-Alpha-Tocopherol
Hazardous ingredients
Retinol, hexadecanoate
Content (W/W): >= 21.4 %
CAS Number: 79-81-2
EC-Number: 201-228-5
Hazard symbol(s): T
R-phrase(s): 38, 61
Page: 2/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
cholecalciferol
Content (W/W): >= 0.1 % - <= 1 %
CAS Number: 67-97-0
Hazard symbol(s): T+
R-phrase(s): 24/25, 26, 48/25
The wording of the hazard symbols and R-phrases is specified in chapter 16 if dangerous ingredients
are mentioned.
3. Hazard identification
Irritating to skin.
May cause harm to the unborn child.
4. First-aid measures
General advice:
First aid personnel should pay attention to their own safety. Remove contaminated clothing.
If inhaled:
Keep patient calm, remove to fresh air, seek medical attention.
On skin contact:
Wash thoroughly with soap and water.
On contact with eyes:
Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open,
consult an eye specialist.
On ingestion:
Rinse mouth immediately and then drink plenty of water, seek medical attention.
Note to physician:
Treatment: Symptomatic treatment (decontamination, vital functions).
5. Fire-fighting measures
Suitable extinguishing media:
water spray, carbon dioxide, dry extinguishing media, foam
Special protective equipment:
Wear a self-contained breathing apparatus.
Further information:
Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.
Page: 3/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
6. Accidental release measures
Environmental precautions:
Do not discharge into drains/surface waters/groundwater.
Methods for cleaning up or taking up:
For small amounts: Contain with absorbent material (e.g. sand, silica gel, acid binder, general
purpose binder, sawdust). After taking up material in containers, cover immediately with water layer.
For large amounts: Dike spillage. Vacuum up spilled product.
Dispose of absorbed material in accordance with regulations.
7. Handling and storage
Handling
Avoid aerosol formation. Processing machines must be fitted with local exhaust ventilation. Ensure
that there is no crystallized product in the container before use.
Protection against fire and explosion:
Prevent electrostatic charge - sources of ignition should be kept well clear - fire extinguishers should
be kept handy.
Storage
Further information on storage conditions: Keep container tightly closed and dry; store in a cool
place. Protect from air. Protect contents from the effects of light.
Protect from temperatures above: 60 癈
Changes in the properties of the product may occur if substance/product is stored above indicated
temperature for extended periods of time.
8. Exposure controls and personal protection
Components with workplace control parameters
none
Personal protective equipment
Respiratory protection:
Respiratory protection in case of vapour/aerosol release. Particle filter Type P2 or FFP2, ( medium
efficiency for solid and liquid particles e.g. EN143,149)
Hand protection:
Suitable chemical resistant safety gloves (EN 374) also with prolonged, direct contact
(Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to
EN 374): E.g. nitrile rubber (0.4 mm), chloroprene rubber (0.5 mm), polyvinylchloride (0.7 mm) and
other
Page: 4/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
Supplementary note: The specifications are based on own tests, literature data and information of
glove manufacturers or are derived from similar substances by analogy. Due to many conditions
(e.g. temperature) it must be considered, that the practical usage of a chemical-protective glove in
practice may be much shorter than the permeation time determined in accordance with EN 374.
Eye protection:
Safety glasses with side-shields (frame goggles) (EN 166)
Body protection:
Body protection must be chosen depending on activity and possible exposure, e.g. apron, protecting
boots, chemical-protection suit (according to DIN-EN 465).
General safety and hygiene measures:
Under no circumstances should the product come into contact with the skin of pregnant women or be
inhaled by them. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and chemical properties
Form: liquid
Colour: yellow
Odour: characteristic
Flash point: > 137 癈
Ignition temperature: > 265 癈
Density: approx. 0.94 g/cm3
(approx. 20 癈)
Solubility (qualitative) solvent(s): organic solvents
soluble
Information on: retinyl palmitate
Partitioning coefficient n-octanol/water (log Pow): > 6 (calculated)
(25 癈)
Information on: cholecalciferol
Partitioning coefficient n-octanol/water (log Pow): > 6.2 (OECD Guideline 117)
----------------------------------
10. Stability and reactivity
Conditions to avoid:
Temperature: > 60 癈
Hazardous reactions:
When finely distributed, self-ignition is possible.
Hazardous decomposition products:
No hazardous decomposition products if stored and handled as prescribed/indicated.
Page: 5/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
11. Toxicological information
Information on: retinyl palmitate
LD50/oral/rat/male/female: > 2,000 mg/kg (BASF-Test)
The product has not been tested. The statement has been derived from products of a similar
structure and composition.
Information on: cholecalciferol
LD50/oral/rat: 35 - 47 mg/kg
Literature data.
----------------------------------
Information on: cholecalciferol
LC50/by inhalation/rat: approx. 0.13 - 0.38 mg/l / 4 h
Literature data.
----------------------------------
Information on: cholecalciferol
LD50/dermal/rat: 61 - 185 mg/kg
Literature data.
----------------------------------
Information on: retinyl palmitate
Primary skin irritation/rabbit: Irritant. (BASF-Test)
----------------------------------
Information on: retinyl palmitate
Primary irritations of the mucous membrane/rabbit: non-irritant (OECD Guideline 405)
----------------------------------
Information on: retinyl palmitate
Animal studies do not fully exclude a skin sensitizing potential.
The product has not been tested. The statement has been derived from products of a similar
structure and composition.
----------------------------------
Further information:
Information on: retinyl palmitate
In the majority of tests performed (microorganisms) a mutagenic effect was not found. A mutagenic
effect was also not observed in in-vivo assays.
Literature data.
Information on: cholecalciferol
No mutagenic effect was found in various tests with bacteria, microorganims and mammalian cell
culture.
Literature data.
----------------------------------
Information on: retinyl palmitate
Results from a number of long-term carcinogenity studies and short-term tests are available. Taking
into account all of the information, there is no indication that the substance itself is carcinogenic.
Literature data.
----------------------------------
Page: 6/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
Information on: retinyl palmitate
In animal studies the substance showed a developmental toxic/teratogenic effect.
Literature data.
Information on: cholecalciferol
The potential to cause toxicity to development cannot be excluded at maternally toxic doses.
Literature data.
----------------------------------
12. Ecological information
Ecotoxicity
Information on: retinyl palmitate
Toxicity to fish:
DIN 38412 Part 15 static
Leuciscus idus/LC50 (96 h): > 100 mg/l
The details of the toxic effect relate to the nominal concentration. The product has not been tested.
The statement has been derived from products of a similar structure and composition.
Information on: cholecalciferol
Toxicity to fish:
DIN 38412 Part 15 static
Leuciscus idus/LC50 (96 h): > 10,000 mg/l
The product has low solubility in the test medium. An aqueous dispersion has been tested. Tested
above maximum solubility. The details of the toxic effect relate to the nominal concentration.
----------------------------------
Information on: retinyl palmitate
Aquatic invertebrates:
Directive 79/831/EEC static
Daphnia magna/EC50 (48 h): 35.34 mg/l
The details of the toxic effect relate to the nominal concentration. The product has low solubility in
the test medium. An aqueous solution prepared with solubilizers has been tested.
Information on: cholecalciferol
Aquatic invertebrates:
OECD Guideline 202, part 1 static
Daphnia magna/EC50 (48 h): > 100 mg/l
The product has low solubility in the test medium. An eluate has been tested. The details of the toxic
effect relate to the nominal concentration. No toxic effects occur within the range of solubility.
----------------------------------
Information on: retinyl palmitate
Aquatic plants:
DIN 38412 Part 9 static
Scenedesmus subspicatus/EC50 (72 h): 25.57 mg/l
The details of the toxic effect relate to the nominal concentration. The product has low solubility in
the test medium. An aqueous solution prepared with solubilizers has been tested.
Page: 7/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
Information on: cholecalciferol
Aquatic plants:
OECD Guideline 201 static
Selenastrum capricornutum/EC50 (96 h): > 100 mg/l
The product has low solubility in the test medium. An eluate has been tested. The details of the toxic
effect relate to the nominal concentration. No toxic effects occur within the range of solubility.
----------------------------------
Information on: retinyl palmitate
Microorganisms/Effect on activated sludge:
DIN 38412 Part 27 (draft) aquatic
Pseudomonas putida/EC10 (30 min): > 10,000 mg/l
The details of the toxic effect relate to the nominal concentration. The product has low solubility in
the test medium. An aqueous solution prepared with solubilizers has been tested.
DIN/EN/ISO 8192-OECD 209-88/302/EEC,P. C aerobic
activated sludge, domestic/EC20 (30 min): > 1,000 mg/l
Information on: cholecalciferol
Microorganisms/Effect on activated sludge:
OECD Guideline 209 aerobic
activated sludge, domestic/EC20 (0.5 h): > 1,000 mg/l
----------------------------------
Information on: retinyl palmitate
Assessment of aquatic toxicity:
Acutely harmful for aquatic organisms.
The inhibition of the degradation activity of activated sludge is not anticipated when introduced to
biological treatment plants in appropriate low concentrations.
Information on: cholecalciferol
Assessment of aquatic toxicity:
There is a high probability that the product is not acutely harmful to aquatic organisms.
No toxic effects occur within the range of solubility.
The inhibition of the degradation activity of activated sludge is not anticipated when introduced to
biological treatment plants in appropriate low concentrations.
----------------------------------
Persistence and degradability
Elimination information
Information on: retinyl palmitate
Test method: OECD Guideline 301 F (aerobic), activated sludge, domestic
Method of analysis: BOD of the ThOD
Degree of elimination: 50 - 60 % (28 d)
Information on: cholecalciferol
Test method: OECD Guideline 301 F (aerobic), activated sludge, domestic
Method of analysis: BOD of the ThOD
Degree of elimination: < 10 % (28 d)
Evaluation: Not readily biodegradable (by OECD criteria).
----------------------------------
Page: 8/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
Information on: retinyl palmitate
Assessment: Not readily biodegradable (by OECD criteria). Moderately/partially
biodegradable.
Information on: cholecalciferol
Assessment: Poorly biodegradable.
----------------------------------
Bioaccumulation potential
Information on: retinyl palmitate
Accumulation in organisms is expected.
Information on: cholecalciferol
Accumulation in organisms is expected.
----------------------------------
13. Disposal considerations
Observe national and local legal requirements.
14. Transport information
Not classified as hazardous under transport regulations ( ADR RID ADNR IMDG/GGVSee
ICAO/IATA )
15. Regulatory information
Regulations of the European union (Labelling) / National legislation/Regulations
Directive 1999/45/EC ('Preparation Directive'):
Hazard symbol(s)
T Toxic.
R-phrase(s)
R38 Irritating to skin.
R61 May cause harm to the unborn child.
S-phrase(s)
S53 Avoid exposure - obtain special instructions before use.
S23.1 Do not breathe spray.
Page: 9/9
BASF Safety data sheet according to 91/155/EEC
Date / Revised: 17.03.2005 Version: 2.0
Product: Vitamin Mischung oelig 02/185
(30082219/SDS_GEN_EU/EN)
Date of print 17.06.2005
Classification according to the calculation method of the directive for preparations (1999/45/EC).
Hazard determinant component(s) for labelling: VITAMIN-A-PALMITATE
Other regulations
16. Other information
Full text of hazard symbols and R-phrases if mentioned as hazardous components in chapter 2:
T Toxic.
T+ Very toxic.
38 Irritating to skin.
61 May cause harm to the unborn child.
24/25 Toxic in contact with skin and if swallowed.
26 Very toxic by inhalation.
48/25 Toxic: danger of serious damage to health by prolonged exposure if
swallowed.
Vertical lines in the left hand margin indicate an amendment from the previous version.
The information contained herein is based on the present state of our knowledge and does not therefore
guarantee certain properties. Recipients of our product must take responsibility for observing existing
laws and regulations.
|