MATERIAL SAFETY DATA SHEET
Revision date: 27-Jun-2006 Version: 1.2 Page 1 of 8
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING
Pfizer Consumer Healthcare Pfizer Ltd
Pfizer Inc Walton Oaks
201 Tabor Road Dorking Road
Morris Plains, NJ 07950 Tadworth
Surrey KT20 7NS, UK
+00 44 (0)1304 616161
Emergency telephone number: Emergency telephone number:
CHEMTREC (24 hours): 1-800-262-8200 ChemSafe (24 hours): +44 (0)208 762 8322
Material Name: Lubriderm Advanced Therapy Moisturizing Lotion
Trade Name: Lubriderm
Chemical Family: Not determined
Intended Use: moisturizing lotion
2. COMPOSITION/INFORMATION ON INGREDIENTS
Hazardous
Ingredient CAS Number EU EINECS List %
Butylated hydroxytoluene 128-37-0 204-881-4 *
Light mineral oil 8042-47-5 232-455-8 *
Cetyl alcohol 36653-82-4 253-149-0 *
Emulsifying wax 8014-38-8 Not listed *
Sodium hydroxide 1310-73-2 215-185-5 *
Glycerin, USP 56-81-5 200-289-5 *
Titanium dioxide 13463-67-7 236-675-5 *
Ingredient CAS Number EU EINECS List %
Cyclomethicone 69430-24-6 Not listed *
Isopropyl Isostearate 68171-33-5 269-023-3 *
Lecithin 8002-43-5 232-307-2 *
Carbomer 9003-01-4 Not listed *
Diazolidinyl urea 78491-02-8 278-928-2 *
Tocopheryl acetate 7695-91-2 231-710-0 *
Xanthan gum 11138-66-2 234-394-2 *
Sodium Pyruvate 113-24-6 204-024-4 *
Iodopropynyl butylcarbamate 55406-53-6 259-627-5 *
Propylene glycol dicaprylate-caprate 68583-51-7 271-516-3 *
PEG-40 Stearate 9004-99-3 Not listed *
Tri (PPG-3 Myristyl ether) Citrate NOT ASSIGNED Not listed *
Sodium benzoate 532-32-1 208-534-8 *
Vitamin A, Retinyl Palmitate 79-81-2 201-228-5 *
Fragrance NOT ASSIGNED Not listed *
Edetate disodium 139-33-3 205-358-3 *
Purified water 7732-18-5 231-791-2 *
Additional Information: * Proprietary
Ingredient(s) indicated as hazardous have been assessed under standards for workplace
safety.
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Material Name: Lubriderm Advanced Therapy Moisturizing Page 2 of 8
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Revision date: 27-Jun-2006 Version: 1.2
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3. HAZARDS IDENTIFICATION
Appearance: Off-white lotion
Signal Word: CAUTION
Statement of Hazard: May cause eye irritation
Eye Contact: May cause eye irritation. (based on components) .
Skin Contact: No data available May cause irritation based on components.
Inhalation: An Occupational Exposure Limit has been established for one or more of the ingredients (see
Section 8).
Ingestion: No data available
EU Indication of danger: Not classified
Additional Information: For a more detailed discussion of potential health hazards and toxicity see Section 11.
Note: This document has been prepared in accordance with standards for workplace safety, which
require the inclusion of all known hazards of the product or its ingredients regardless of the
potential risk. The precautionary statements and warnings included may not apply in all cases.
Your needs may vary depending upon the potential for exposure in your workplace.
4. FIRST AID MEASURES
Eye Contact: Immediately flush eyes with water for at least 15 minutes. If irritation occurs or persists, get
medical attention.
Skin Contact: Wash exposed area with soap and water, remove contaminated clothing and obtain medical
assistance if irritation occurs.
Ingestion: Get medical attention. Do not induce vomiting unless directed by medical personnel. Give
water to dilute unless instructed to do otherwise.
Inhalation: Remove to fresh air. If discomfort persists, get medical attention.
5. FIRE FIGHTING MEASURES
Extinguishing Media: Use carbon dioxide, dry chemical, or water spray.
Hazardous Combustion Products: Emits toxic fumes of carbon monoxide, and hydrogen cyanide.
Fire Fighting Procedures: Wear approved positive pressure, self-contained breathing apparatus and full protective turn
out gear.
Fire / Explosion Hazards: Fine particles (such as dust and mists) may fuel fires/explosions.
Additional Information: Toxic gases may be emitted in fires of this material.
6. ACCIDENTAL RELEASE MEASURES
Health and Safety Precautions: Personnel involved in clean-up should wear appropriate personal protective equipment (see
Section 8). Minimize exposure.
Measures for Cleaning / Collecting: Use non-combustible absorbent material to wipe up spill and place in a sealed container for
disposal. Clean spill area thoroughly.
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Revision date: 27-Jun-2006 Version: 1.2
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Measures for Environmental Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to
Protections: avoid environmental release.
Additional Consideration for Large Spills should be handled by vacuuming or wet mopping. Clean spill area thoroughly.
Spills:
Additional Information: Review Sections 3, 8 and 12 before proceeding with clean up.
7. HANDLING AND STORAGE
General Handling: Avoid contact with eyes. Avoid breathing vapor or mist.
Storage Conditions: Keep in tightly closed containers away from heat and light.
Storage Temperature: Store as directed by product packaging.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Butylated hydroxytoluene
ACGIH Threshold Limit Value (TWA) 2 mg/m?TWA
Sodium hydroxide
OSHA - Final PELS - TWAs: 2 mg/m?br>
ACGIH Ceiling Threshold Limit: 2 mg/m?br>
Glycerin, USP
OSHA - Final PELS - TWAs: 15 mg/m?total dust
5 mg/m?respirable fraction
ACGIH Threshold Limit Value (TWA) 10 mg/m?TWA
Titanium dioxide
OSHA - Final PELS - TWAs: 15 mg/m?total dust
ACGIH Threshold Limit Value (TWA) 10 mg/m?TWA
The exposure limit(s) listed for solid components are only relevant if dust may be generated.
Engineering Controls: Good general ventilation should be sufficient to control airborne levels.
Personal Protective Equipment:
Hands: Wear protective gloves when working with large quantities.
Eyes: Glasses or goggles are recommended if eye contact is possible.
Skin: Not required for the normal use of this product.
Respiratory protection: None required under normal conditions of use. If the applicable Occupational Exposure Limit
(OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control
exposures to below the OEL.
9. PHYSICAL AND CHEMICAL PROPERTIES:
Physical State: Lotion Color: Off-white
Molecular Formula: Mixture Molecular Weight: Mixture
pH: 5.0 - 5.5
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Revision date: 27-Jun-2006 Version: 1.2
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10. STABILITY AND REACTIVITY
Stability: Stable
Conditions to Avoid: Avoid direct sunlight, conditions that might generate heat, and sources of ignition.
Incompatible Materials: None known
Hazardous Decomposition Products: None known
Polymerization: No data available
11. TOXICOLOGICAL INFORMATION
General Information: The information included in this section describes the potential hazards of the individual
ingredients.
Acute Toxicity: (Species, Route, End Point, Dose)
Sodium hydroxide
Mouse IP LD50 40 mg/kg
Emulsifying wax
Mouse Oral 15,000 mg/kg
Titanium dioxide
Rat Oral LD50 > 7500 mg/kg
Rat Subcutaneous LD 50 50 mg/kg
Light mineral oil
Rat Oral LD50 > 24 g/kg
Cetyl alcohol
Rat Oral LD50 5000 mg/kg
Rabbit Dermal LD50 > 2,600 mg/kg
Mouse Oral LD50 3200 mg/kg
Glycerin, USP
Mouse Oral LD50 4090 mg/kg
Rat Oral LD50 12.6 g/kg
Rabbit Dermal LD50 > 10 g/kg
> 570 mg/m3
Rat Inhalation LC50 1hr
Cyclomethicone
Rat Oral LD50 > 16,000 mg/kg
Rabbit Dermal LD50 > 16,000 mg/kg
Lecithin
Rat Oral LD50 > 8 ml/kg
Diazolidinyl urea
Rat Oral LD50 2570 mg/kg
Rabbit Dermal LD50 > 2000 mg/kg
Rat Inhalation LC50 4.5h (50% aq. solution) 1.3 mg/kg
Sodium benzoate
Rat Oral LD50 4,070 mg/kg
Mouse Oral LD50 1600 mg/kg
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Xanthan gum
Rat Oral LD50 > 5000 mg/kg
Iodopropynyl butylcarbamate
Rat Oral LD50 1470 mg/kg
Rabbit Dermal LD50 > 2000 mg/kg
Rat Inhalation LC50 4h 670 mg/kg (dust)
Rat Inhalation LC50 4h 630 mg/kg (aerosol)
Butylated hydroxytoluene
Rat Oral LD50 1700 mg/kg
Mouse Oral LD50 650 mg/kg
Rat Oral LD50 890 mg/kg
Mouse Intraperitoneal LD 50 138 mg/kg
Acute Toxicity Comments: A greater than symbol (>) indicates that the toxicity endpoint being tested was not achievable
at the highest dose used in the test.
Irritation / Sensitization: (Study Type, Species, Severity)
Sodium hydroxide
Eye Irritation Rabbit Severe
Skin Irritation Rabbit Severe
Glycerin, USP
Eye Irritation Rabbit Mild
Vitamin A, Retinyl Palmitate
Skin Irritation Rabbit Mild
Eye Irritation Rabbit Mild
Butylated hydroxytoluene
Eye Irritation Rabbit Moderate
Skin Irritation Rabbit Moderate
Repeated Dose Toxicity: (Duration, Species, Route, Dose, End Point, Target Organ)
Sodium benzoate
10 Day(s) Rat Oral 27370 mg/kg LOAEL Liver, Blood
10 Day(s) Mouse Oral 45 g/kg LOAEL Liver, Kidney, Blood, Ureter, Bladder
Butylated hydroxytoluene
4 Week(s) Rat Oral 5185 mg/kg LOAEL Liver
4 Day(s) Mouse Oral 2000 mg/kg LOAEL Liver, Kidney, Ureter, Bladder
Reproduction & Development Toxicity: (Duration, Species, Route, Dose, End Point, Effect(s))
Sodium benzoate
Embryo / Fetal Development Rat Oral 44 g/kg LOEL Developmental toxicity
Butylated hydroxytoluene
Embryo / Fetal Development Rat Oral 6 g/kg LOEL Teratogenic
Carcinogen Status: None of the components of this formulation are listed as a carcinogen by IARC, NTP or OSHA.
See below
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Titanium dioxide
IARC: Group 3
Butylated hydroxytoluene
IARC: Group 3
Carbomer
IARC: Group 3
12. ECOLOGICAL INFORMATION
Environmental Overview: The environmental characteristics of this material have not been fully evaluated. Releases to
the environment should be avoided. See aquatic toxicity data for individual components below:
Aquatic Toxicity: (Species, Method, End Point, Duration, Result)
Diazolidinyl urea
Rainbow Trout LC50 96 Hours > 100 mg/L
Daphnia magna LC50 48 Hours 34.9 mg/L
Iodopropynyl butylcarbamate
Rainbow Trout LC50 96 Hours 0.72 mg/L
Daphnia magna LC50 48 Hours 0.16 mg/L
Aquatic Toxicity Comments: A greater than (>) symbol indicates that acute ecotoxicity was not observed at the maximum
solubility. Since the substance is insoluble in aqueous solutions above this concentration, an
acute ecotoxicity value (i.e. LC/EC50) is not achievable.
13. DISPOSAL CONSIDERATIONS
Disposal Procedures: Observe all local and national regulations when disposing of this material.
14. TRANSPORT INFORMATION
Not regulated for transport under USDOT, EUADR, IATA, or IMDG regulations.
15. REGULATORY INFORMATION
EU Indication of danger: Not classified
OSHA Label:
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Revision date: 27-Jun-2006 Version: 1.2
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CAUTION
May cause eye irritation
Canada - WHMIS: Classifications
WHMIS hazard class:
None required
This product has been classified in accordance with the hazard criteria of the CPR and the MSDS contains all of the information
required by the CPR.
Cyclomethicone
Inventory - United States TSCA - Sect. 8(b) Listed
Isopropyl Isostearate
EU EINECS List 269-023-3
Inventory - United States TSCA - Sect. 8(b) Listed
Lecithin
EU EINECS List 232-307-2
Inventory - United States TSCA - Sect. 8(b) Listed
Carbomer
Inventory - United States TSCA - Sect. 8(b) Listed
Diazolidinyl urea
EU EINECS List 278-928-2
Inventory - United States TSCA - Sect. 8(b) Listed
Butylated hydroxytoluene
EU EINECS List 204-881-4
Inventory - United States TSCA - Sect. 8(b) Listed
Tocopheryl acetate
EU EINECS List 231-710-0
Inventory - United States TSCA - Sect. 8(b) Listed
Xanthan gum
EU EINECS List 234-394-2
Inventory - United States TSCA - Sect. 8(b) Listed
Sodium Pyruvate
EU EINECS List 204-024-4
Inventory - United States TSCA - Sect. 8(b) Listed
Iodopropynyl butylcarbamate
CERCLA/SARA 313 Emission reporting 1.0% de minimis concentration
EU EINECS List 259-627-5
Inventory - United States TSCA - Sect. 8(b) Listed
Light mineral oil
EU EINECS List 232-455-8
Inventory - United States TSCA - Sect. 8(b) Listed
Propylene glycol dicaprylate-caprate
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Revision date: 27-Jun-2006 Version: 1.2
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EU EINECS List 271-516-3
Inventory - United States TSCA - Sect. 8(b) Listed
PEG-40 Stearate
Inventory - United States TSCA - Sect. 8(b) Listed
Sodium benzoate
EU EINECS List 208-534-8
Inventory - United States TSCA - Sect. 8(b) Listed
Vitamin A, Retinyl Palmitate
EU EINECS List 201-228-5
Inventory - United States TSCA - Sect. 8(b) Listed
Cetyl alcohol
EU EINECS List 253-149-0
Inventory - United States TSCA - Sect. 8(b) Listed
Sodium hydroxide
CERCLA/SARA Hazardous Substances 1000 lb final RQ
and their Reportable Quantities: 454 kg final RQ
EU EINECS List 215-185-5
Inventory - United States TSCA - Sect. 8(b) Listed
Edetate disodium
EU EINECS List 205-358-3
Inventory - United States TSCA - Sect. 8(b) Listed
Glycerin, USP
EU EINECS List 200-289-5
Inventory - United States TSCA - Sect. 8(b) Listed
Purified water
EU EINECS List 231-791-2
Inventory - United States TSCA - Sect. 8(b) Listed
Titanium dioxide
EU EINECS List 236-675-5
Inventory - United States TSCA - Sect. 8(b) Listed
16. OTHER INFORMATION
Reasons for Revision: Updated Section 2 - Composition / Information on Ingredients. Updated Section 7 - Handling
and Storage. Updated Section 11 - Toxicology Information. Updated Section 12 - Ecological
Information.
Prepared by: Corporate Occupational Toxicology & Hazard Assessment
Pfizer Inc believes that the information contained in this Material Safety Data Sheet is accurate, and while it is provided in good faith, it
is without a warranty of any kind, expressed or implied.
End of Safety Data Sheet
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