SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 02/09/2004
Date Updated: 07/16/2003
Version 1.3
Section 1 - Product and Company Information
Product Name DICHLOROACETIC ACID, 99+%
Product Number D54702
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
DICHLOROACETIC ACID 79-43-6 No
Formula C2H2Cl2O2
Synonyms Bichloracetic acid * DCA (acid) * Dichloracetic
acid * Dichlorethanoic acid * Dichloroacetic acid
(IUPAC) * 2,2-Dichloroacetic acid *
Dichloroethanoic acid * Kyselina dichloroctova
(Czech) * Urner's liquid
RTECS Number: AG6125000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Corrosive.
Causes severe burns.
Readily absorbed through skin.
HMIS RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
235 癋 113 癈 Method: closed cup
AUTOIGNITION TEMP
194 癈
FLAMMABILITY
N/A
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Ventilate
area and wash spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
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shoes. Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
Molecular Weight 128.94 AMU
pH 1.2 20 癈 Concentration: 129
g/l
BP/BP Range 193 - 195 癈
MP/MP Range 13 癈
Freezing Point N/A
Vapor Pressure 0.19 mmHg 20 癈
Vapor Density 4.5 g/l
Saturated Vapor Conc. N/A
SG/Density 1.567 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 0.942
Decomposition Temp. N/A
Flash Point 235 癋 113 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 194 癈
Refractive Index 1.466
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: ETHANOL, ETHER
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong bases, Strong
reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Readily absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
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the mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: May be harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
TOXICITY DATA
Oral
Rat
2820 mg/kg
LD50
Skin
Rabbit
510 UL/KG
LD50
IRRITATION DATA
Skin
Rabbit
2 mg
24H
Remarks: Severe irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Species: Rat
Route of Application: Oral
Dose: 100 GM/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 427 GM/KG
Exposure Time: 61W
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Species: Rat
Route of Application: Oral
Dose: 101 GM/KG
Exposure Time: 60W
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Species: Mouse
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Route of Application: Oral
Dose: 58800 MG/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 4 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rat
Dose: 14 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
CHRONIC EXPOSURE - MUTAGEN
Species: Mouse
Route: Oral
Dose: 1800 MG/KG
Exposure Time: 9D
Mutation test: Micronucleus test
Species: Mouse
Route: Oral
Dose: 645 MG/KG
Mutation test: DNA damage
Species: Mouse
Dose: 600 MG/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 400 MG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 9 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 24 GM/KG
Route of Application: Oral
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Exposure Time: (6-15D PREG)
Result: Effects on Newborn: Sex ratio.
Section 12 - Ecological Information
N/A
ACUTE ECOTOXICITY TESTS
Test Type: LC0 Bacteria
Value: 100 - 1,000 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 106 - 2,600 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Dichloroacetic acid
UN#: 1764
Class: 8
Packing Group: Packing Group II
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Dichloroacetic acid
IATA UN Number: 1764
Hazard Class: 8
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: C N
Indication of Danger: Corrosive. Dangerous for the environment.
R: 35 50
Risk Statements: Causes severe burns. Very toxic to aquatic
organisms.
S: 26 45 61
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Corrosive.
Risk Statements: Causes severe burns.
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
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In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Take off immediately all
contaminated clothing. Wear suitable protective clothing,
gloves, and eye/face protection.
US Statements: Readily absorbed through skin.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: California Proposition 65: This product is
or contains chemical(s) known to the state of California to
cause cancer. California Proposition 65: This product is or
contains chemical(s) known to the state of California to cause
cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide.
Sigma-Aldrich Inc., shall not be held liable for any damage
resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms
and conditions of sale. Copyright 2004 Sigma-Aldrich Co. License
granted to make unlimited paper copies for internal use only.
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