SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 21/FEB/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
1 - Product and Company Information
Product Name CAPTOPRIL
Product Number C4042
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CAPTOPRIL 62571-86-2 263-607-1 None
Formula C9H15NO3S
Molecular Weight 217.29 AMU
Synonyms Capoten * (-)-Captopril * L-Captopril *
Captopryl *
1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline *
1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline
(S,S) * D-3-Mercapto-2-methylpropanoyl-L-proline
* D-3-Mercapto-2-methylpropionylproline *
1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline
*
(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
* D-2-Methyl-3-mercaptopropanoyl-L-proline *
L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-,
(S)- * SA 333 * SQ 14,225
3 - Hazards Identification
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Fine crystals
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Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 104 - 108 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1 g/ml H2O very slightly hazy,
colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: UY0550000
ACUTE TOXICITY
LDLO
Oral
Man
16 mg/kg
LDLO
Oral
Man
2.5 mg/kg
3D-I
Remarks: Kidney, Ureter, Bladder:Urine volume decreased. Kidney,
Ureter, Bladder:Other changes.
LDLO
Oral
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Woman
1.5 mg/kg
7W
Remarks: Behavioral:Somnolence (general depressed activity).
Vascular:BP lowering not charactertized in autonomic section.
Lungs, Thorax, or Respiration:Dyspnea.
LDLO
Oral
Man
2.68 mg/kg
5D-I
Remarks: Behavioral:Somnolence (general depressed activity).
Nutritional and Gross Metabolic:Changes in:K
LD50
Oral
Rat
4245 mg/kg
LD50
Subcutaneous
Rat
>600 MG/KG
LD50
Intravenous
Rat
554 MG/KG
LD50
Oral
Mouse
2500 mg/kg
LD50
Subcutaneous
Mouse
>2400 MG/KG
LD50
Intravenous
Mouse
663 MG/KG
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
May cause hematopoiesis, renal toxicity, erosion\ulceration of
stomach, varation of retinal blood vessels, pruritus, taste
disturbance. To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
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TARGET ORGAN INFORMATION
Kidneys. Cardiovascular system. Blood.
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 40 MG/KG
Route of Application: Oral
Exposure Time: (15-30D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Man
Dose: 228 MG/KG
Route of Application: Oral
Exposure Time: (43W MALE)
Result: Paternal Effects: Breast development.
Species: Rat
Dose: 48 GM/KG
Route of Application: Oral
Exposure Time: (30D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Rat
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rabbit
Dose: 8250 UG/KG
Route of Application: Oral
Exposure Time: (24-28D PREG)
Result: Effects on Fertility: Other measures of fertility
Effects on Embryo or Fetus: Fetal death.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
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of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
S-PHRASES: 22 24/25
Do not breathe dust. Avoid contact with skin and eyes.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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