SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 21/FEB/2005
Date Updated: 14/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CARBAMAZEPINE
Product Number C4024
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CARBAMAZEPINE 298-46-4 206-062-7 None
Formula C15H12N2O
Molecular Weight 236.27 AMU
Synonyms Amizepin * Biston * Carbamazepen * Carbamazepine
* 5-Carbamoyl-5H-dibenz(b,f)azepine *
Carbazepine * Finlepsin * G 32883 * Geigy 32883
* Karbamazepin * Neurotol * Stazepine * Tegretal
* Tegretol * Telesmin * Timonil
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. May cause sensitization by inhalation and
skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range N/A
MP/MP Range 191 - 192 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: HN8225000
ACUTE TOXICITY
LDLO
Oral
Man
54 mg/kg
9D-I
Remarks: Behavioral:Ataxia. Kidney, Ureter, Bladder:Urine volume
increased. Blood:Agranulocytosis.
LDLO
Oral
Woman
1920 mg/kg
17W-I
Remarks: Blood:Aplastic anemia.
LD50
Oral
Rat
1957 mg/kg
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Remarks: Behavioral:Altered sleep time (including change in
righting reflex).
LD50
Intraperitoneal
Rat
158 MG/KG
LD50
Subcutaneous
Rat
>1500 MG/KG
LD50
Oral
Mouse
529 mg/kg
LD50
Intraperitoneal
Mouse
114 MG/KG
LD50
Subcutaneous
Mouse
>1 GM/KG
LD50
Oral
Dog
5620 mg/kg
LD50
Oral
Rabbit
2680 mg/kg
LD50
Oral
Guinea pig
920 mg/kg
SENSITIZATION
Sensitization: May cause allergic respiratory and skin reactions
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Anemia. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves. Blood. Liver. Kidneys. Endocrine system.
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CHRONIC EXPOSURE - TERATOGEN
Species: Woman
Dose: 96 MG/KG
Route of Application: Oral
Exposure Time: (3W PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Woman
Dose: 3192 MG/KG
Route of Application: Oral
Exposure Time: (1-38W PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Effects on Newborn: Growth
statistics (e.g., reduced weight gain). Effects on Newborn:
Delayed effects.
Species: Woman
Dose: 7644 MG/KG
Route of Application: Oral
Exposure Time: (1-39W PREG)
Result: Specific Developmental Abnormalities: Skin and skin
appendages. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Woman
Dose: 1288 MG/KG
Route of Application: Oral
Exposure Time: (26-42W PREG)
Result: Specific Developmental Abnormalities: Skin and skin
appendages.
Species: Rat
Dose: 4800 MG/KG
Route of Application: Oral
Exposure Time: (7-18D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 2400 MG/KG
Route of Application: Oral
Exposure Time: (7-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 440 MG/KG
Route of Application: Oral
Exposure Time: (6-16D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 5628 MG/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue).
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Species: Mouse
Dose: 9984 MG/KG
Route of Application: Oral
Exposure Time: (8-13D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 3492 MG/KG
Route of Application: Oral
Exposure Time: (1-39W PREG/17D POST)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 3600 MG/KG
Route of Application: Oral
Exposure Time: (14D PRE/1-22D PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Weaning or
lactation index (e.g., # alive at weaning per # alive at day 4).
Effects on Newborn: Growth statistics (e.g., reduced weight
gain).
Species: Rat
Dose: 765 MG/KG
Route of Application: Oral
Exposure Time: (9-17D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Effects on
Embryo or Fetus: Fetal death.
Species: Rat
Dose: 7200 MG/KG
Route of Application: Oral
Exposure Time: (7-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 92 GM/KG
Route of Application: Oral
Exposure Time: (2W MALE/2W PRE-18D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
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solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 42/43
Harmful if swallowed. May cause sensitization by inhalation and
skin contact.
S-PHRASES: 22 36/37/39
Do not breathe dust. Wear suitable protective clothing, gloves,
and eye/face protection.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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