SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 21/FEB/2005
Date Updated: 12/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CARBON TETRACHLORIDE, ANHYDROUS, >=99.5%
Product Number 289116
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CARBON TETRACHLORIDE 56-23-5 200-262-8 602-008-00-5
Formula CCl4
Molecular Weight 153.82 AMU
Synonyms Benzinoform * Carbona * Carbon chloride (CCl4) *
Carbon TET * Carbon tetrachloride (ACGIH:OSHA) *
Chlorid uhlicity (Czech) * Czterochlorek wegla
(Polish) * ENT 4,705 * ENT 27164 * Flukoids *
Halon 1040 * Methane tetrachloride * Methane,
tetrachloro- * Necatorina * Perchloromethane * R
10 * RCRA waste number U211 * R 10 (Refrigerant)
* Tetrachloorkoolstof (Dutch) *
Tetrachloormetaan * Tetrachlorkohlenstoff, tetra
(German) * Tetrachlormethan (German) *
Tetrachlorocarbon * Tetrachloromethane (OSHA) *
Tetrachlorure de carbone (French) *
Tetraclorometano (Italian) * Tetracloruro di
carbonio (Italian) * Tetrafinol * Tetraform *
Tetrasol * Univerm * Vermoestricid
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect. Toxic: danger of
serious damage to health by prolonged exposure through inhalation.
Harmful to aquatic organisms, may cause long-term adverse effects
in the aquatic environment. Dangerous for the ozone layer.
Carc. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
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handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 20 MG/M3
Poland NDSCh 100 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 6.3 mg/m3
1 ppm
Remarks: HK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 65 mg/m3
10 ppm
Remarks: 4
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 13 mg/m3
2 ppm
Remarks: HK
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level13 mg/m3
2 ppm
Remarks: H, K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 30 mg/m3
5 ppm
Remarks: H D M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 13 mg/m3
2 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 77 掳C
MP/MP Range -23 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
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Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 143 mmHg 30 掳C
SG/Density 1.59 g/cm3
Partition Coefficient Log Kow: 2.83
Viscosity 2.03 Pas
Vapor Density 5.32 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 32.3 mN/m
Conductivity N/A
Miscellaneous Data N/A
Solubility Other Solvents: SOLUBLE IN ETHANOL, ACETONE,
NAPHTHA MISCIBLE WITH: ALCOHOL, BENZENE,
CHLOROFORM, E
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Phosgene gas, Hydrochloric acid.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: FG4900000
ACUTE TOXICITY
LDLO
Oral
Man
429 mg/kg
Remarks: Cardiac: Change in rate. Lungs, Thorax, or
Respiration:Cyanosis. Kidney, Ureter, Bladder:Interstitial
nephritis.
LCLO
Inhalation
Human
1,000 ppm
LCLO
Inhalation
Human
5 PPH/5M
LD50
Oral
Rat
2350 mg/kg
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LC50
Inhalation
Rat
8,000 ppm
4H
LD50
Skin
Rat
5070 mg/kg
LD50
Intraperitoneal
Rat
1500 UL/KG
LD50
Oral
Mouse
8263 mg/kg
LC50
Inhalation
Mouse
9,526 ppm
8H
LD50
Intraperitoneal
Mouse
572 MG/KG
LD50
Subcutaneous
Mouse
31 GM/KG
Remarks: Behavioral:Sleep. Behavioral:Ataxia.
LD50
Intraperitoneal
Dog
1500 MG/KG
Remarks: Liver:Liver function tests impaired.
LD50
Oral
Rabbit
5760 mg/kg
LD50
Skin
Rabbit
> 20000 mg/kg
LD50
Intravenous
Rabbit
5840 MG/KG
Remarks: Behavioral:Excitement. Behavioral:Coma. Lungs, Thorax,
or Respiration:Dyspnea.
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LD50
Oral
Guinea pig
5760 mg/kg
LD50
Skin
Guinea pig
>9400 UL/KG
LD50
Intraperitoneal
Chicken
4497 MG/KG
Remarks: Gastrointestinal:Ulceration or bleeding from small
intestine. Gastrointestinal:Other changes.
LD50
Oral
Mammal
6000 mg/kg
LC50
Inhalation
Mammal
34,500 mg/m3
IRRITATION DATA
Skin
Human
Remarks: If not removed promptly, local application of Carbon
Tetrachloride to human skin produces distinct pain with
erythema, hyperemia and wheal formation followed by vesication.
Skin
Rabbit
4 mg
Remarks: Mild irritation effect
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
2.2 mg
30S
Remarks: Mild irritation effect
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Stomach pains, vomiting, diarrhea. Nausea,
dizziness, and headache. Damage to the eyes. Damage to the
liver. Damage to the kidneys. Exposure to and/or consumption of
alcohol may increase toxic effects.
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ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Eyes. Nerves. Heart.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Subcutaneous
Exposure Time: 12W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 19W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Skin and Appendages: Other: Tumors.
Mouse
Route of Application: Parenteral
Exposure Time: 30W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Hamster
Route of Application: Oral
Exposure Time: 30W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Hepatitis, fibrous (cirrhosis, post-necrotic
scarring). Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 88D
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Subcutaneous
Exposure Time: 25W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Subcutaneous
Exposure Time: 12W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Subcutaneous
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Exposure Time: 70W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Endocrine:Thyroid tumors.
Mouse
Route of Application: Oral
Exposure Time: 9W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 12W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Rat
367 UMOL/KG
Intraperitoneal
DNA
Rat
31 GM/KG
Subcutaneous
12W
DNA damage
Rat
3 MMOL/L
Cell Type: liver
DNA damage
Rat
100 MG/KG
Intraperitoneal
Other mutation test systems
Rat
100 MG/KG
Intraperitoneal
Unscheduled DNA synthesis
Rat
1400 MG/KG
Oral
Unscheduled DNA synthesis
Rat
50 MG/KG
Oral
Other mutation test systems
Rat
31 GM/KG
Subcutaneous
12W
Cytogenetic analysis
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Mouse
367 UMOL/KG
Intraperitoneal
DNA
Mouse
10 UMOL
Cell Type: liver
DNA
Mouse
335 UMOL/KG
Oral
DNA damage
Mouse
6550 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
100 MG/KG
Oral
Unscheduled DNA synthesis
Mouse
2 GM/KG
Oral
DNA inhibition
Hamster
500 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
1600 UMOL/L
Cell Type: lung
SLN
Mammal
1 MMOL/L
Cell Type: lymphocyte
DNA
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 3 GM/KG
Route of Application: Oral
Exposure Time: (14D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rat
Dose: 300 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system. Specific Developmental Abnormalities:
Homeostasis
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Species: Rat
Dose: 2384 MG/KG
Route of Application: Parenteral
Exposure Time: (18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Hepatobiliary system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 2 GM/KG
Route of Application: Oral
Exposure Time: (7-8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 150 MG/KG
Route of Application: Oral
Exposure Time: (8D PREG)
Result: Maternal Effects: Other effects. Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants).
Species: Rat
Dose: 750 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 250 PPM/8H
Route of Application: Inhalation
Exposure Time: (10-15D PREG)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Newborn: Weaning or
lactation index (e.g., # alive at weaning per # alive at day 4).
Species: Rat
Dose: 71500 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (15D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Rat
Dose: 5 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Paternal Effects: Other effects on male.
CMR CAT.: Carc. Cat.3
12 - Ecological Information
BIOACCUMULATION POTENTIAL: No indication of
bioaccumulation.
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ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 42 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 530 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 27 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 35 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1846
Class: 6.1
PG: II
Proper Shipping Name: Carbon tetrachloride
IMDG
UN#: 1846
Class: 6.1
PG: II
Proper Shipping Name: Carbon tetrachloride
Marine Pollutant: Yes
Severe Marine Pollutant: No
IATA
UN#: 1846
Class: 6.1
PG: II
Proper Shipping Name: Carbon tetrachloride
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-008-00-5
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 23/24/25 40 48/23 52/53 59
Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect. Toxic: danger of
serious damage to health by prolonged exposure through
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inhalation. Harmful to aquatic organisms, may cause long-term
adverse effects in the aquatic environment. Dangerous for the
ozone layer.
S-PHRASES: 23 36/37 45 59 61
Do not breathe vapor. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible). Refer to
manufacturer/supplier for information on recovery/recycling.
Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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