SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 20/NOV/2005
Date Updated: 10/FEB/2005
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CAPSAICIN
Product Number M2028
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CAPSAICIN 404-86-4 206-969-8 None
Formula C18H27NO3
Molecular Weight 305.42 AMU
Synonyms Capsaicin * Capsaicine *
N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-
nonenamide *
trans-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-met
hyl-6-nonenamide *
(E)-8-Methyl-N-vanillyl-6-nonenamide *
trans-8-Methyl-N-vanillyl-6-nonenamide *
NCI-C56564 * 6-Nonenamide, 8-methyl-N-vanillyl-,
(E)- (8CI)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed. Irritating to respiratory system and skin.
Risk of serious damage to eyes. May cause sensitization by
inhalation and skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 66 掳C
Flash Point 113 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 50 mg/ml CHCl3 Clear
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: RA8530000
ACUTE TOXICITY
LD50
Oral
mouse, male
118.8 mg/kg
LD50
Oral
mouse, female
97.4 mg/kg
LD50
Oral
rat, male
161.2 mg/kg
LD50
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Oral
rat, female
148.1 mg/kg
LD50
Intraperitoneal
Rat
9500 UG/KG
Remarks: Behavioral:Muscle contraction or spasticity.
Behavioral:Excitement. Behavioral:Convulsions or effect on
seizure threshold.
LD50
Oral
Mouse
47.2 mg/kg
LD50
Skin
Mouse
> 512 mg/kg
LD50
Intraperitoneal
Mouse
6500 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Subcutaneous
Mouse
9000 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Intravenous
Mouse
400 UG/KG
LD50
Intramuscular
Mouse
7800 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Intratracheal
Mouse
1600 UG/KG
Remarks: Behavioral:Excitement. Behavioral:Convulsions or effect
on seizure threshold. Behavioral:Muscle contraction or
spasticity.
LD50
Rectal
Mouse
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>218 MG/KG
LD50
Intraperitoneal
Rabbit
>50 MG/KG
LD50
Intraperitoneal
Guinea pig
1100 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Intraperitoneal
Hamster
>120 MG/KG
SENSITIZATION
Sensitization: May cause allergic reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Lachrymator. Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CONDITIONS AGGRAVATED BY EXPOSURE
Causes sneezing. Do not inhale.
CHRONIC EXPOSURE - CARCINOGEN
Mouse
Route of Application: Oral
Exposure Time: 5W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Mouse
7500 UG/KG
Intraperitoneal
Micronucleus test
Mouse
1800 UG/KG
Intraperitoneal
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DNA inhibition
Mouse
93120 UG/KG
Intraperitoneal
32D
Sister chromatid exchange
Hamster
5 MG/L (+S9)
Cell Type: lung
Mutation in microorganisms
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25-37/38-41-42/43
Toxic if swallowed. Irritating to respiratory system and skin.
Risk of serious damage to eyes. May cause sensitization by
inhalation and skin contact.
S-PHRASES: 22-26-28-36/39-45
Do not breathe dust. In case of contact with eyes, rinse
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immediately with plenty of water and seek medical advice. After
contact with skin, wash immediately with plenty of soap-suds.
Wear suitable protective clothing and eye/face protection. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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