SIGMA-ALDRICH



                         Material Safety Data Sheet



                                               Date Printed: 21/FEB/2005

                                               Date Updated: 10/FEB/2005

                                                             Version 1.2

                                                 According to 91/155/EEC



Classified as Hazardous according to the criteria of EU Annex 1 and

NOHSC.



1 - Product and Company Information



Product Name                   CALYCULIN A FROM DISCODERMIA CALYX

Product Number                 C5552



Company                        Sigma-Aldrich Pty, Ltd

                               Unit 2, 14 Anella Avenue

                               Castle Hill NSW 1765

                               Australia

Technical Phone #              +61 2 9841 0555

Fax                            +61 2 9841 0500

Emergency Phone #              +61 2 9841 0566



2 - Composition/Information on Ingredients



Product Name                         CAS #       EC no      Annex I

                                                            Index Number

CALYCULIN A                          101932-71-2 None       None



Formula             C50H81N4O15P

Molecular Weight    1,009.18 AMU



3 - Hazards Identification



SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT

   Toxic by inhalation, in contact with skin and if swallowed.

   Irritating to skin.





4 - First Aid Measures



AFTER INHALATION

   If inhaled, remove to fresh air. If not breathing give

   artificial respiration. If breathing is difficult, give oxygen.



AFTER SKIN CONTACT

   In case of skin contact, flush with copious amounts of water for

   at least 15 minutes. Remove contaminated clothing and shoes.

   Call a physician.



AFTER EYE CONTACT

   In case of contact with eyes, flush with copious amounts of

   water for at least 15 minutes. Assure adequate flushing by

   separating the eyelids with fingers. Call a physician.



AFTER INGESTION

   If swallowed, wash out mouth with water provided person is

   conscious. Call a physician immediately.



5 - Fire Fighting Measures

EXTINGUISHING MEDIA

   Suitable: Water spray. Carbon dioxide, dry chemical powder, or

   appropriate foam.



SPECIAL RISKS

   Specific Hazard(s): Emits toxic fumes under fire conditions.



SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS

   Wear self-contained breathing apparatus and protective clothing

   to prevent contact with skin and eyes.



6 - Accidental Release Measures



PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL

   Evacuate area.



PROCEDURE(S) OF PERSONAL PRECAUTION(S)

   Wear self-contained breathing apparatus, rubber boots, and heavy

   rubber gloves.



METHODS FOR CLEANING UP

   Sweep up, place in a bag and hold for waste disposal. Avoid

   raising dust. Ventilate area and wash spill site after material

   pickup is complete.



7 - Handling and Storage



HANDLING

   Directions for Safe Handling: Do not breathe dust. Do not get in

   eyes, on skin, on clothing. Avoid prolonged or repeated exposure.



STORAGE

   Conditions of Storage: Keep tightly closed. Store under argon.

   Store at -20°C



SPECIAL REQUIREMENTS: Light sensitive.



8 - Exposure Controls / Personal Protection



ENGINEERING CONTROLS

   Use only in a chemical fume hood. Safety shower and eye bath.



GENERAL HYGIENE MEASURES

   Wash contaminated clothing before reuse. Wash thoroughly after

   handling.



PERSONAL PROTECTIVE EQUIPMENT

   Respiratory Protection: Government approved respirator.

   Hand Protection: Compatible chemical-resistant gloves.

   Eye Protection: Chemical safety goggles.



9 - Physical and Chemical Properties



Appearance              Physical State: Solid



Property                Value                 At Temperature or Pressure



pH                      N/A

BP/BP Range             N/A

MP/MP Range             N/A

Flash Point             N/A





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Flammability            N/A

Autoignition Temp       N/A

Oxidizing Properties    N/A

Explosive Properties    N/A

Explosion Limits        N/A

Vapor Pressure          N/A

SG/Density              N/A

Partition Coefficient   N/A

Viscosity               N/A

Vapor Density           N/A

Saturated Vapor Conc.   N/A

Evaporation Rate        N/A

Bulk Density            N/A

Decomposition Temp.     N/A

Solvent Content         N/A

Water Content           N/A

Surface Tension         N/A

Conductivity            N/A

Miscellaneous Data      N/A

Solubility              N/A



10 - Stability and Reactivity



STABILITY

   Stable: Stable.

   Conditions to Avoid: Light.

   Materials to Avoid: Strong oxidizing agents.



HAZARDOUS DECOMPOSITION PRODUCTS

   Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,

   Phosphorous oxides, Nitrogen oxides.



HAZARDOUS POLYMERIZATION

   Hazardous Polymerization: Will not occur



11 - Toxicological Information



SIGNS AND SYMPTOMS OF EXPOSURE

   Possible tumor promoter. Exposure can cause: Gastrointestinal

   disturbances.



ROUTE OF EXPOSURE

   Skin Contact: Causes skin irritation.

   Eye Contact: May cause eye irritation.

   Inhalation: Material may be irritating to mucous membranes and

   upper respiratory tract.

   Multiple Routes: Toxic by inhalation, ingestion, or skin

   absorption.



TARGET ORGAN INFORMATION

   Smooth muscle.



CONDITIONS AGGRAVATED BY EXPOSURE

   The toxicological properties have not been thoroughly

   investigated.



12 - Ecological Information



No data available.



13 - Disposal Considerations







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SUBSTANCE DISPOSAL

   Contact a licensed professional waste disposal service to dispose

   of this material. Dissolve or mix the material with a combustible

   solvent and burn in a chemical incinerator equipped with an

   afterburner and scrubber. Observe all federal, state, and local

   environmental regulations.



14 - Transport Information



RID/ADR

   UN#: 3462

   Class: 6.1

   PG: III

   Proper Shipping Name: Toxins, extracted from living

   sources, solid, n.o.s.



IMDG

   UN#: 3462

   Class: 6.1

   PG: III

   Proper Shipping Name: Toxins, extracted from living

   sources, solid, n.o.s.

   Marine Pollutant: No

   Severe Marine Pollutant: No

   Technical Name: Required



IATA

   UN#: 3462

   Class: 6.1

   PG: III

   Proper Shipping Name: Toxins, extracted from living

   sources, solid, n.o.s.

   Inhalation Packing Group I: No

   Technical Name: Required



15 - Regulatory Information



CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES

   INDICATION OF DANGER: T

     Toxic.

   R-PHRASES: 23/24/25 38

     Toxic by inhalation, in contact with skin and if swallowed.

     Irritating to skin.

   S-PHRASES: 45 36/37/39

     In case of accident or if you feel unwell, seek medical advice

     immediately (show the label where possible). Wear suitable

     protective clothing, gloves, and eye/face protection.



16 - Other Information



WARRANTY

   The above information is believed to be correct but does not

   purport to be all inclusive and shall be used only as a guide. The

   information in this document is based on the present state of our

   knowledge and is applicable to the product with regard to

   appropriate safety precautions. It does not represent any

   guarantee of the properties of the product. Sigma-Aldrich Inc.,

   shall not be held liable for any damage resulting from handling or

   from contact with the above product. See reverse side of invoice

   or packing slip for additional terms and conditions of sale.

   Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited

   paper copies for internal use only.





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DISCLAIMER

   For R&D use only. Not for drug, household or other uses.









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