SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 27/APR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HYDROXYLAMINE HYDROCHLORIDE, 99.9999%
Product Number 379921
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HYDROXYLAMINE HYDROCHLORIDE 5470-11-1 226-798-2 612-123-00-2
Formula H2NOH.HCl
Molecular Weight 69.49 AMU
Synonyms Hydroxyamine hydrochloride * Hydroxyammonium
chloride * Hydroxylamine chloride *
Hydroxylamine chloride (1:1) * Hydroxylammonium
chloride * Oxammonium hydrochloride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes and skin. May cause
sensitization by skin contact. Harmful: danger of serious damage
to health by prolonged exposure if swallowed. Very toxic to
aquatic organisms.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Explosion Hazards: Container explosion may occur under fire
conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Air and moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
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Form: Fine crystals
Property Value At Temperature or Pressure
pH 2.5 - 3.5 20 藲C Concentration: 50
g/l
BP/BP Range N/A
MP/MP Range 155 - 157 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.67 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture. Air.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nitrogen oxides, Hydrogen
chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NC3675000
ACUTE TOXICITY
LD50
Oral
Rat
141 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Mouse
408 mg/kg
LD50
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Intraperitoneal
Mouse
10 MG/KG
LD50
Subcutaneous
Mouse
125 MG/KG
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Absorption into the body leads to the formation of
methemoglobin which in sufficient concentration causes cyanosis.
Onset may be delayed 2 to 4 hours or longer. May cause
convulsions.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Blood.
CHRONIC EXPOSURE - MUTAGEN
Human
10 MG/L
Cell Type: Other cell types
Other mutation test systems
Human
25 MG/L
Cell Type: leukocyte
Cytogenetic analysis
Rat
19500 NG/PLATE
Cell Type: Embryo
Morphological transformation.
Mouse
220 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
72 UMOL/L
Cell Type: Embryo
Cytogenetic analysis
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Mouse
31300 UG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
72 UMOL/L
Cell Type: Other cell types
Cytogenetic analysis
Hamster
5 MMOL/L
Cell Type: lung
Sister chromatid exchange
Monkey
50 MG/L
Cell Type: kidney
Micronucleus test
Monkey
25 MG/L
Cell Type: kidney
Cytogenetic analysis
Monkey
25 MG/L
Cell Type: kidney
Other mutation test systems
Mammal
500 MG/L
Cell Type: lymphocyte
Cytogenetic analysis
Mammal
25 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
ZNEG
Histidine reversion (Ames)
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 1 - 10 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
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14 - Transport Information
RID/ADR
UN#: 2923
Class: 8
PG: II
Proper Shipping Name: Corrosive solid, toxic, n.o.s.
IMDG
UN#: 2923
Class: 8
PG: II
Subrisk: 6.1
Proper Shipping Name: Corrosive solid, toxic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2923
Class: 8
PG: II
Subrisk: 6.1
Proper Shipping Name: Corrosive solid, toxic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-123-00-2
INDICATION OF DANGER: Xn N
Harmful. Dangerous for the environment.
R-PHRASES: 22 36/38 43 48/22 50
Harmful if swallowed. Irritating to eyes and skin. May cause
sensitization by skin contact. Harmful: danger of serious
damage to health by prolonged exposure if swallowed. Very toxic
to aquatic organisms.
S-PHRASES: 22 24 37 61
Do not breathe dust. Avoid contact with skin. Wear suitable
gloves. Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
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or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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