SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HYDROCORTISONE, 98%
Product Number 286095
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HYDROCORTISONE 50-23-7 200-020-1 None
Formula C21H30O5
Molecular Weight 362.47 AMU
Synonyms Aeroseb-HC * Anti-inflammatory hormone * Barseb
HC * Cetacort * Cobadex * Compound F (kendall) *
Cort-Dome * Cortef * Cortenema * Cortifan *
Cortisol alcohol * Cortispray * Cortonema *
Cortril * Dermolate * Dihydrocostisone *
Domolene-HC * Efcorbin * Efcorteclan * Ficortril
* Genacort * HC * Heb-Cort * Hidro-colisona *
Hycort * Hycortol * Hycortole * Hydro-Adreson *
Hydrocortisone * 11-beta-Hydrocortisone *
Hydrocortistab * Hydrocortisyl * Hydrocortone *
17-Hydroxycorticosterone * Hydroxycortisone *
11-beta-Hydroxycortisone * Hytone * Hytone
lotion * Incortin-H * Kendall's compound F * NSC
10483 * Optef * Otosone-F * Permicort * Polcort
H * Pregn-4-ene-3,20-dione,
11,17,21-trihydroxy-, (11-beta)- *
4-Pregnene-11-beta,17-alpha,21-triol 3,20-dione
* Reichstein's substance M * Scheroson F *
Signef * Tarcortin * Texacort lotion 25 *
Topicort *
11-beta,17,21-Trihydroxypregn-4-ene-3,20-dione *
11-beta,17-alpha,21-Trihydroxypregn-4-ene-3,20-di
one *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Possible risk of harm to the unborn child.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place. Store in the dark.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 220 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GM8925000
ACUTE TOXICITY
LD50 LD50
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Intraperitoneal Intraperitoneal
Rat Rat
150 MG/KG 150 MG/KG
Remarks: Biochemical:Metabolism (intermediary): Effect on
inflammation or mediation of inflammation.
Biochemical:Metabolism (intermediary): Effect on inflammation or
mediation of inflammation.
LD50 LD50
Subcutaneous Subcutaneous
Rat Rat
449 MG/KG 449 MG/KG
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Nutritional and Gross Metabolic:Weight
loss or decreased weight gain.
LD50 LD50
Subcutaneous Subcutaneous
Mouse Mouse
>500 MG/KG >500 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Immune system. Pituitary. Adrenal cortex.
CHRONIC EXPOSURE - MUTAGEN
Human Human
2 MMOL/L 2 MMOL/L
Cell Type: liver liver
DNA DNA
Rat Rat
20 MG/KG 20 MG/KG
Intraperitoneal Intraperitoneal
Unscheduled DNA synthesis Unscheduled DNA synthesis
Rat Rat
100 MG/KG 100 MG/KG
Intraperitoneal Intraperitoneal
DNA inhibition DNA inhibition
Rat Rat
1 MG/L 1 MG/L
Cell Type: mammary gland mammary gland
DNA inhibition DNA inhibition
Mouse Mouse
100 NMOL/L 100 NMOL/L
Cell Type: Other cell types Other cell types
DNA inhibition DNA inhibition
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Mouse Mouse
50 MG/KG 50 MG/KG
Intraperitoneal Intraperitoneal
Cytogenetic analysis Cytogenetic analysis
Guinea pig Guinea pig
1 MG/L 1 MG/L
Cell Type: lung lung
Unscheduled DNA synthesis Unscheduled DNA synthesis
Guinea pig Guinea pig
50 MG/KG 50 MG/KG
Intraperitoneal Intraperitoneal
DNA inhibition DNA inhibition
Guinea pig Guinea pig
1 MG/L 1 MG/L
Cell Type: lung lung
DNA inhibition DNA inhibition
Chicken Chicken
10 MG/L 10 MG/L
Cell Type: Embryo Embryo
Unscheduled DNA synthesis Unscheduled DNA synthesis
Chicken Chicken
450 PMOL/L 450 PMOL/L
Cell Type: Embryo Embryo
DNA inhibition DNA inhibition
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat Rat
Dose: 330 MG/KG 330 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (1-22D PREG) (1-22D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain). Specific Developmental Abnormalities: Endocrine system.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain).
Species: Rat Rat
Dose: 220 MG/KG 220 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (9-19D PREG) (9-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Endocrine system. Effects on Newborn: Biochemical and metabolic.
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Endocrine
system. Effects on Newborn: Biochemical and metabolic.
Species: Rat Rat
Dose: 200 MG/KG 200 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (14-15D PREG) (14-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetotoxicity
(except death, e.g., stunted fetus).
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Species: Rat Rat
Dose: 500 MG/KG 500 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (13D PREG) (13D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue). Effects on Embryo or
Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Rat Rat
Dose: 50 MG/KG 50 MG/KG
Route of Application: Parenteral Parenteral
Exposure Time: (16-18D PREG) (16-18D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
Effects on Embryo or Fetus: Other effects to embryo.
Species: Mouse Mouse
Dose: 10 MG/KG 10 MG/KG
Route of Application: Oral Oral
Exposure Time: (11-14D PREG) (11-14D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Craniofacial (including nose and tongue).
Species: Mouse Mouse
Dose: 156 MG/KG 156 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (11-14D PREG) (11-14D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Craniofacial (including nose and tongue).
Species: Mouse Mouse
Dose: 200 MG/KG 200 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (12D PREG) (12D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Craniofacial (including nose and tongue).
Species: Mouse Mouse
Dose: 200 MG/KG 200 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (12D PREG) (12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Mouse Mouse
Dose: 4 MG/KG 4 MG/KG
Route of Application: Intraplacental Intraplacental
Exposure Time: (11D PREG) (11D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Other developmental abnormalities.
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Rabbit Rabbit
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Dose: 2945 UG/KG 2945 UG/KG
Route of Application: Ocular Ocular
Exposure Time: (6-18D PREG) (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Embryo or Fetus: Fetal death.
Species: Guinea pig Guinea pig
Dose: 12 MG/KG 12 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (16-17D PREG) (16-17D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Homeostasis Specific Developmental
Abnormalities: Eye, ear. Specific Developmental Abnormalities:
Homeostasis
Species: Hamster Hamster
Dose: 150 MG/KG 150 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (12D PREG) (12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue). Effects on Embryo or
Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Hamster Hamster
Dose: 400 MG/KG 400 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (11D PREG) (11D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material). Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue). Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material). Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat Rat
Dose: 210 MG/KG 210 MG/KG
Route of Application: Oral Oral
Exposure Time: (14D PRE) (14D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Uterus, cervix, vagina.
Species: Rat Rat
Dose: 80 MG/KG 80 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (14-15D PREG) (14-15D PREG)
Result: Effects on Newborn: Biochemical and metabolic. Effects
on Newborn: Biochemical and metabolic.
Species: Rat Rat
Dose: 50 MG/KG 50 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (18D PREG) (18D PREG)
Result: Effects on Newborn: Biochemical and metabolic. Effects
on Newborn: Biochemical and metabolic.
Species: Rat Rat
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Dose: 35 MG/KG 35 MG/KG
Route of Application: Parenteral Parenteral
Exposure Time: (7D PRE) (7D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Uterus, cervix, vagina.
Species: Mouse Mouse
Dose: 400 MG/KG 400 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (11-14D PREG) (11-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue). Effects on Fertility: Post-implantation
mortality (e.g., dead and/or resorbed implants per total number
of implants). Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse Mouse
Dose: 400 MG/KG 400 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (11-14D PREG) (11-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue). Effects on Fertility: Post-implantation
mortality (e.g., dead and/or resorbed implants per total number
of implants). Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse Mouse
Dose: 400 MG/KG 400 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (11-14D PREG) (11-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue). Effects on Fertility: Post-implantation
mortality (e.g., dead and/or resorbed implants per total number
of implants). Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rabbit Rabbit
Dose: 6 MG/KG 6 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (24-26D PREG) (24-26D PREG)
Result: Effects on Newborn: Other neonatal measures or effects.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain). Effects on Newborn: Other neonatal measures or effects.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain).
Species: Hamster Hamster
Dose: 333 MG/KG 333 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (10D PREG) (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Post-implantation mortality (e.g., dead
and/or resorbed implants per total number of implants).
12 - Ecological Information
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No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 63
Possible risk of harm to the unborn child.
S-PHRASES: 36/37
Wear suitable protective clothing and gloves.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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